LabSmith uprocess System Microfluidic Automation

Transcription

1 LabSmith uprocess System Microfluidic Automation Automated fluid delivery and rou ng Innova ve so ware for coordinated controlol Constant-pressure or constant-rate flow Accurate temperature control and monitoringing Fast, simple automa on construc on LabSmith s uprocess system provides hardware and so ware that simplifies construc on and control of microfluidic systems. uprocess devices include AV series automated selector valves, SPS01 programmable syringe pumps, ups pressure sensors, uts temperature sensors, ute thermalelectric modules, and prototyping breadboards. Coordinated, Automated Fluid Control uprocess devices connect to CapTite microfluidic interconnect products to make it easy to build and rebuild micro- and nano-fluidic circuits. This results in zero dead-volumes and compa ble, quick-to-assemble fluid interfaces, taking the hassle out of fluid rou ng. All components are available for connec on to 360 μm, 1/32 or 1/16 tubing. SPS01 Programmable Syringe Pumps can be configured for total fluids volumes of 5 to 100 μl, with step sizes as low as 8 nl. The compact pump design (100 mm long x 25 mm wide) is op mal for applica ons striving to minimize tubing length or overall footprint. AV-Series Automated Selector Valves are available in 3, 4, and 6 port configura ons. The small size, zero dead volumes, and low swept volumes minimize sample use. ups Pressure Sensors are ideal for monitoring and controlling pressure in microfluidic circuits. The 13 mm diameter sensors can be threaded into any CapTite port, allowing easy integra on into a microfluidic circuit via microfluidic chips, tees, or reservoirs to minimize dead-volume and form factor. uts Temperature Sensor and ute Thermal-Electric Modules are ideal for monitoring and controlling temperatures in micro-applica ons. Programmable Automated Opera on uprocess So ware makes it easy to control and monitor uprocess devices and other LabSmith instruments via a laptop or PC. Sequences are simple to enter into uprocess for mul step, coordinated automa on: make a precision pressure source from a ups pressure sensor, reservoir, and syringe pump; use flourescence signals from LabSmith s SVM340 for triggering or feedback; scan mul plexed arrays; coordinate pressure driven and electrically driven flow with LabSmith s HVS448. Motorized mo on, real- me image processing, valves, sensors, pumps, and high voltage: a complete kit for the microfluidics developer. uprocess so ware provides a simple interface to control uprocess devices and create automated processes.

2 uprocess Hardware I J Components of a Typical uprocess Setup EIB200 uprocess Interface is required to control SPS01 syringe pumps, AV201 automated valves, or ups01 pressure sensors. upb or ibb breadboard (upb-05 shown) is op onal, for simplified component moun ng. SPS01 Programmable Syringe Pump. 4VM01 Valve Manifold controls up to four AV201, AV202, or AV303 automated valves. AV201 Automated Valve. 4AM01 Analog Manifold controls up to four ups pressure sensors. ups-series pressure sensor can be used to monitor and regulate pressure, allowing syringe pumps to be run in constant pressure or constant flow rate mode. ute-series thermal-electric module. uts -series temperature sensor. 4PM01 Power Module Device Interface Interface Power ELECTRONIC MANIFOLDS (REQUIRED FOR VALVE AND SENSOR OPERATION) 4VM01 4AM01 4PM01 uprocess INTERFACE (EIB200) Control up to 128 uprocess devices (syringes, automated valves and/or sensors) micro USB 12 volt, 1 amp external power supply included uprocess so ware included LabVIEW drivers included So ware Developers Kit (C, C++) included Controls up to 4 valves Controls up to 4 pressure or temperature sensors Controls up to 4 power devices (such as ute01) uprocess BREADBOARDS (OPTIONAL) uprocess breadboards have integrated connectors for uprocess devices and ¼" hole spacing for moun ng LabSmith valves and CapTite microfluidic connector products A C E G upb-05 upb-08 upb x 132 mm (7.3 x 5.2") breadboard; connec ons for 5 devices 254 x 229 mm (10 x 9") breadboard; connec ons for 8 devices 305 x 305 mm (12 x 12") breadboard; connec ons for 12 devices D H ibb 254 x 229 mm (10 x 9") breadboard with connec ons for up to 8 devices; 2.5 x 7.6 cm (1 x 3") cutout for viewing microsystems on LabSmith SVM340 Synchronous Video Microscope F B J I To view prices and place orders, create an account at or info@labsmith.com. CapTite and uprocess are trademarks of LabSmith, Inc. Delrin and Teflon are registered trademarks of DuPont. PEEK is a trademark of Victrex plc. LabVIEW is a trademark of Na onal Instruments, Inc LabSmith, Inc. 03/17. All specifica ons are subject to change without no ce Southfront Road, Suite E Livermore, CA Phone (925) info@labsmith.com

3 LabSmith SPS01 Syringe Pumps Automated fluid delivery Small footprint Zero dead-volume direct connec on to tubing Flow rates as low as 50 nl/min Precision Delivery, Remarkable Size Only 100 mm long, the SPS01 syringe pump is a big step in system miniaturiza on, using a frac on of the space and power of a conven onal syringe pump. Mul ple pumps pack densely, reducing interconnect volumes and flow-lag for ght, accurate dispensing and flow control. The versa le SPS01 delivers volumes from 5 to 100 μl, with a wide range of available flow rates, and step sizes as low as 8 nl. With pressure feedback from the ny ups sensor and flow damping from the compact BBRES reservoir, the SPS01 performs like an agile precision pressure source for the most demanding applica ons. Low Dead Volume, Easy Cleaning The SPS01 s unique syringe glass design directly connects to 360 μm OD capillary, 1/32 tubing, or 1/16 OD tubing via a LabSmith CapTite connector. The direct connec on eliminates adapters, resul ng in very low dead volumes. The pump body allows syringes to be easily removed and replaced, so a pump can be configured with a wide range of syringe volumes and interfaces. All we ed surfaces are easily removed for steriliza on and autoclaving. 1in 25mm 3.1in 80mm Model Dimensions Housing Material Syringe Material Plunger Material Wet Volumes Stroke Length Tip Interface Max Volume (μl) PHYSICAL 100 x 25 x 20 mm (3.9 x 1.0 x 0.79 ) L x W x H Delrin PERFORMANCE Glass with PEEK p Stainless steel with Teflon p 5, 10, 20, 50, and 100 μl (interchangable, all volumes supported with the same housing) 12 mm Min Flow Rate (μl/min) Max Flow Rate (μl/min) Step Size (nl) Max Pressure (psig) > > > Volume Accuracy Flow Rate Accuracy Service Temperature Range ~ 1 % (infuse direc on) ~ 1 % (infuse direc on) F (10 80 C) Directly connects to 360 μm OD capillary via CapTite C one piece fi ng; selected sizes available for 1/32 OD or 1/16 OD tubing 0.8in 21mm in mm

4 LabSmith AV Series Automated Valves Small footprint High pressure Nanoliter swept volume Easy integra on with other uprocess devices Big performance in a small size LabSmith s uprocess automated valves deliver programmable fluid rou ng in a frac on of the footprint required for most valves. With nanoliter swept volumes and opera on pressures up to 5 kpsi, the AV series valves are ideal for most microfluidic rou ng applica ons. The AV201 selector valve has three ports and uses an L pa ern for flow rou ng. Fluid flow through AV201 valve The AV202 four-port sample valve routes the fluid simultaneously between two sets of adjacent ports. This valve, paired with two syringe pumps, can provide a con nuous delivery of solu on for a low flow-rate, long-dura on applica on. The six-port AV303 sample valve routes the fluid between three sets of adjacent ports, ideal for con nuous flow sample collec on and injec on. All valve models feature zero dead volume connec ons, rapid flow response me, low carryover, < 1 second switching, inert we ed materials, and zero hold power. All valves are also available with a rotary knob for manual applica ons. Fluid flow through AV202 valve. Fluid flow through AV303 valve VALVE AV201-C360 AV201-T132 AV201-T116 CAPILLARY OR TUBING INTERFACE 360 μm OD 1/32 OD 1/16 OD SWEPT VOLUME 130 nl 130 nl AV202-C360 AV202-T μm OD 1/32 OD 90 nl* AV[xxx]-C360 and AV[xxx]-T132 valve dimensions AV[xxx]-T116 valve dimensions AV303-C360 * swept volume per leg 360 μm OD 60 nl*

5 ups Micro Pressure Sensors Part of the uprocess System Compact, low-dead-volume design Threads directly to LabSmith CapTite ports The ups pressure sensors are designed for accurate, 115 psia) connectors, and interconnects, for in-line pressure

6 LabSmith ups Pressure Sensor Specifications Range ( ) Maximum Pressure Damage Pressure Resolu on Pa abs [35 psia] 5 Pa abs 1 Pa Pa abs [115 psia] 16 Pa abs 5 Pa Pa abs [26 psia] 25 Pa abs 11 Pa Model (YYYY) C360 T116 CapTite Component Compa bility ompa ble with all 36 for 36 um OD capillar ) or T132 for 1/32 OD tubing) components ompa ble with all T116 components 1/16 OD tubing) Accuracy (ZZ) Dri Hysteresis Scale Thermal 01 < 2% of F S < 1% of F S < 2% of F S < 3% of F S / Other Features Temperature Range (for speci ed accuracy) Working Temperature Housing material Fill Measures Vacuum? Internal volume (oil lled) Electrical connec on PEEK Per ourinated oil es 6 5 l 2 mm pitch, 2 pin, dual row receptacle Accessories EIB100 EIB200 4AM01 4AM02 upb-05 upb-08 upb-12 ibb uprocess Interface control of AM manifold and other uprocess devices; includes uprocess TM so ware, ab IEW TM drivers, and SDK Analog Sensor Manifolds control up to sensors uprocess Breadboards op onal pla orm for moun ng AM manifold and other micro uidic devices Contact us for more information LabSmith, Inc Southfront Road, Suite E Livermore, CA USA info@labsmith.com Tel: 1(925)

7 LabSmith uprocess TM Thermal Control Products ute-series thermal-electric modules and 4PM01 power module for controlled heating and cooling uts-series temperature sensors and 4AM01 analog sensor module for on-chip or in-fluid temperature measurement Interfaces with uprocess TM software for coordinated micro-system control ute-series Thermal-Electric Module Part Number Specification: ute01-[peltier] Required Interface 4PM01 four channel power module (connects via 6-pin flat flex ribbon cable) Mounting holes two M2x0.4 threaded holes, 12.7 mm (0.5 ) spacing Maximum Temperature / DT 130 C / 67 C Peltier Options [PELTIER] Size (mm) Qmax (W) Vmax (V) Imax (A) x 30 x uts-series Temperature Sensor Part Number Specification: uts01-[tc]-[l] Temperature Range Accuracy Resolution Sensor type Required Interface Length in cm [L] Mounting hole 150 C 200 C 0.5 C C K type thermocouple 4AM01 four channel analog module (connects via 6-pin flat flex ribbon cable) 20 or 60 cm (custom lengths available) 2.8 mm (0.11 ) through-hole for mounting to uprocess breadboard via /4 screw Sensor Options [TC] Wire Gauge Tip Diameter (mm) Tip Insulation Wire Insulation STD None PFA INS FEP FEP

8 uprocess TM Thermal Control ute01-[peltier] uts01-std-[l] uts01-ins-[l] Accessories EIB200: USB Interface for computer control of 4AM01, 4PM01, and other uprocess devices; includes uprocess TM software, LabVIEW TM drivers, and SDK. 4AM01: Analog manifold for control of up to 4 uts temperature sensors or ups pressure sensors. 4PM01: Power manifold for automatable and closed-loop control of up to 4 ute thermalelectric modules or other loads. Voltage range Current range Maximum Power 5 to 5 V -4 to 4 A 15 W ute heat sink: HS-0808 (8.9 x 8.9 mm) or HS-2020 (20 x 20 mm) black anodized aluminum heat sink with adhesive backing. uprocess TM breadboard (upb-05, upb-08, upb-12, or ibb): Optional platform for mounting uprocess TM devices and CapTite TM components. Updated 01/17