Research on the micro liquid flow standard system and inter-comparison

Transcription

1 Proposal of 2018 APMP TC Initiative Project Research on the micro liquid flow standard system and inter-comparison Type of Project: Comparison Technique January 1, December 31, 2019 Seok Hwan LEE Korea Research Institute of Standards and Science

2 Project Participants Korea Research Institute of Standards and Science, KRISS - Dr. Seok Hwan Lee (Senior researcher) - seokhwan.lee@kriss.re.kr, Tel: National Metrology Institute of Japan, NMIJ - Dr. Kar-Hooi Cheong (Senior researcher) - kh.cheong@aist.go.jp, Tel: Center for Measurement Standards, CMS - Mr. Kun-Chih Tsai (Senior researcher) - KCTsai@itri.org.tw, Tel: National Institute of Metrology (Thailand), NIMT - Dr. Theerarak Chinarak (Flow Metrologist) - theerarak@nimt.or.th, Tel: ext. 2103

3 Contents Background The research content of this project Budget of this project

4 Micro flow system Needs for accurate measurement in medical fields Fluke IDA-5 - Accident with (drug) infusion pump: 56,000 cases/yr, 500 cases of death (Year , FDA) - Market of Infusion pump $8.5 billion /2019 by Kalorama report Needs of standard(traceability) for calibration Pump Scope Measurement System Harvard PHD 2200 Infusion Pump

5 Micro flow system Need in metrological issue - Infusion pump generate flowrates with pulsation - Dynamic gravimetric method for micro flow measurement Infusion pump Flowrates with time in infusion pump

6 Micro flow system Needs of energy field Evaluation of fuel efficiency 26.8 km/l Fuel Blender Fuel A Fuel B (bio-fuel) (gasoline) FM1 FM2 Fuel efficiency Flow metering for evaluation of automobile fuel efficiency at engine test bench. Fuel consumption at micro flow rate for hybrid vehicles and vehicles with idling-stop mode. Traceability to national standard required by international standards. Bio-fuel production Accurate and reliable flow metering devices in fuel blender that mixes bio-fuel and gasoline at the point of consumption. Household fuel-supply system Accurate fuel-metering in centralized fuel supply system for correct and reliable realtime consumption rate of each household. 灯油タンク 微燃料油メータ

7 Micro flow system Micro flow systems of NMIs, EURAMET KC (MeDD)

8 Micro flow system KRISS micro liquid flow standard system - Flow rate range: 16 μl/min 16 ml/min, U = 0.7 % with k=2 - Uncertainty : % (k=2) - Tube diameter : Φ 1/8 - Temperature : 10 ⁰C 40 ⁰C - Pressure : 0 5 bar Water chamber Weighing tank with evaporation trap Pressure based pump Flowrate sensor Device under test

9 Micro flow system NMIJ micro liquid flow standard system - Flow rate range: 333 μl/min ml/min - Working liquid: liquid hydrocarbon (kerosene, light oil) - Expanded uncertainty (k=2): % (mass flow rate), % (volumetric flow rate) - Tube diameter : φ1/8 - φ1/4 inch - Temperature : 15 o C 35 o C - Pressure : MPa 100g weighing system (liquid collection for 333 μl/min~ 16.7 ml/min) K-H Cheong et al Meas. Sci. Technol. 29 (2018) Weighing section (liquid collection) Test section (DUT mounting) Flow generation section (tank, pump)

10 Micro flow system CMS micro liquid flow standard system - Flow rate range: 0.1 μl/min to 10 ml/min - Uncertainty : 2.0 % to 0.2 % - Tube diameter : 1/8 inch (adaptor is available) - Temperature : 15 to 27 - Pressure : 1 kpa to 200 kpa Micro Flowrate flow calibration system Configuration of the micro flow calibration system

11 Micro flow system NIMT small liquid flow standard system - Flow rate range: ( ) ml/h - Uncertainty : 2.0% to 0.2% 1. Water Supply system UUC 2. Weighing System - Working liquid : water - Tube diameter :φ1/8 - φ1/4 inch - Temperature : C 3. Data acquisition system - Pressure : (0.5 5) bar UUC Weighing System

12 NMIs research objectives Development of micro liquid flowmeter and pump calibration facility - The measuring flow rate is ranged from hundreds μl/h to hundreds ml/h. Analysis of micro flow meter and syringe pump for different flow rates - Characteristics of micro flow meter and syringe pump will be analyzed for different flow rates. Comparison of micro liquid flow standard system in APMP - Micro flow meter and syringe pump are used as a transfer standard.

13 The research content of this project Establish of micro liquid flow standard facility - Producing stable micro flow rate - Controlling micro flow rate - Preventing evaporation of water(oil) on balance - Calculating uncertainty of micro liquid flow system nl/min μl/min ml/min Bio-Chip Systems Microarrays Lab-on-a-Chip Nano-Jet Tech Chemistry Micro Reactors Synthesis Chip Fabs Evaporators Coating Systems Medical Drug Dosing (Disposable & Non-Disposable) Medical Compliance Monitoring Dialysis Anesthesia Industrial Process Technology Mixture Processes Cooling Systems Gluing& Sealing Automation Analytical Instruments (Bio/Med Tech) Pipetting / Dispensing Liquid Chromatography & Mass Spectrometry

14 The research content of this project Characteristics of micro flow devices - Pulsating of flow rate from syringe pump - Accuracy of flow meter and pump at low flow rate Flow rate with time from syringe pump Syringe pump Setup of syringe pump calibration Flow rate with time from syringe pump

15 The research content of this project Transfer standard of this comparison - KRISS will provide Coriolis flow meter and syringe pump - Flow rate : ml/h - Temperature : C - Pressure : 1-5 bar - Working fluid : water or oil Syringe pump Coriolis flowmeter

16 Budget of this project

17 Thank you 2018 APMP meeting