Locations in Taiwan. Offices are located close to customers sites Taipei Scientech HQ (1979)

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1 辛耘企業股份有限公司林哲英

2 What We Do Industries which we serve: Semiconductor (front-end, back-end and GaAs), FPD/LCD, LED, Solar Cell, Data Storage, Scientific Instruments, General Industries etc. Business Scope: Agent/Distributer, Service and Manufacturing. 2

3 Scientech Company Establishment: 1979 Capital: US$ 21 Million (NTD 600 Million) Founder and CEO/President: H.L. Hsieh 2013 March will be Listed Company 3

4 Locations in Taiwan Offices are located close to customers sites Taipei Scientech HQ (1979) Linko Office (1999) Huko Factory (2007) Hsinchu Office (1990) Taichung Office (1999) Tainan Office (1999) Kaohsiung Office (1987) 4

5 Locations in China Suzho u Beijing office (2004) Tianjin office (2001) Jinin office (2010) Chongqing office (2010) Wuhan office (2011) Wuxi office (2003) Shanghai Office (2001) Shenzhen (2011) Quinming (2002) 5

6 500 persons in total 40 persons in Administration 22 persons in Scientific Instrument Division 12 persons in General Industries Division 197 persons in Wafer Reclaim Division 125 persons in Semi/Opto. Division 30 in sales/marketing, 95 in Service/Application 101 persons in Equipment Mf g Division 6

7 DANI Instruments Company Presentation Massimo Cazzaniga DANI Instruments S.p.A.

8 DANI Instruments is the only European company designing, manufacturing and marketing GC and GC/MS instrumentation DANI Instruments

9 The company was established in 1975 by a group of experts in the field of analytical instrumentation. They have devoted their knowledge to the new gas chromatographic technique cooperating with the most prestigious Italian scientific institutes. Scientific experience together with managerial capability have allowed DANI to become a prestigious company well known all over the world. DANI was the first company in the world to launch the PTV injector, established, by experts, as a reference injector in GC because of its considerable number of utilities. The use and application of innovative technology has taken DANI to the implementation of the Valve & Loop system in the Static Head Space Sampler, which is considered the most outstanding product and one of the major strength points of DANI, covering one third of the total market. DANI Instruments

10 DANI has continued to implement innovative techniques by introducing in the market very reliable, extremely versatile and easy to use instruments that meet with the users real requirements. DANI has diversified its activities by entering in the field of molecular sensors which are developed and manufactured in Switzerland in the new factory located in Contone. Recently DANI has introduced, first company in Europe, a new Time of Flight GC/MS suitable for FAST Gas Chromatography. DANI means: Development in ANalytical Instrumentation DANI Instruments

11 1975: First DANI Gas Chromatograph GC : First DANI Head Space Sampler HSS : First DANI Capillary GC GC : Symposium of Hindelang 1981: Presentation of Programmable Temperature Vaporizer PTV 1985: Manufacturing Agreement with Hewlett Packard for 1985: Head Space Sampler HSS (HP19395A) 1987: First DANI Thermal Desorber STD : First DANI Natural Gas Analyzer PGC : Head Space Sampler HSS : Digital Gas Chromatograph GC : DANI Natural Gas Analyzer PGC DANI Instruments - Milestones

12 DANI Instruments - Milestones 2000: Digital Gas Chromatograph GC nd Series 2000: Head Space Sampler HSS nd Series 2002: Thermal Desorber STD : New MASTER Line 2006: Fast Gas Chromatograph MASTER GC 2006: Liquid Autosampler MASTER AS 2006: Thermal Desorber MASTER TD 2007: DANI GC Capillary Columns DN series 2009: Dynamic Headspace Sampler MASTER DHS 2009: Time of Flight GC/MS MASTER TOF

13 In the last 5 years we run FAST

14 DANI Instruments is the only company able to renew and design a complete line of new instruments in the last 4 years 2007 Master GC Master AS 2007 Master TD 2009 Master TOF 2009 Master DHS 2011 Master SHS DANI Instruments

15 we approached the market with Total Solutions DANI Instruments

16 A new concept of Time Of Flight GC-MS MASTER TOF Time Of Flight GC/MS Products Portfolio

17 A Dynamic approach to High Sensitivity Headspace Analysis MASTER DHS Dynamic Headspace Samper Products Portfolio

18 Excellent precision with Extreme Simplicity Master SHS Headspace Samper Products Portfolio

19 Ultimate Solution for High Sensitive Detection of Volatiles MASTER TD Thermal Desorber Products Portfolio

20 HSS Headspace Sampler

21 in the last 4 years we developed more than one hundred applications able to cover all the main industries Applications Industries Applications TOF GCxGC TOF GC DHS TD HSS Analyzers Perfumes Aroma Profile X X Perfumes Allergens X X X Perfumes Pesticides X Cosmetics Aroma Profile X X Cosmetics Allergens X X X Cosmetics Pesticides X Food FAME Triglycerides - Sterols X Food Aroma Profile X X X X Food Allergens X X Food/Agricolture Pesticides X Food/Agricolture Pesticides Screening X X Wineries Methanol in Ethanol X Distilleries Ethanol and Methanol X Biodiesel FAME Investigation X Biodiesel ASTM Methods X DANI Instruments

22 in the last 4 years we developed more than one hundred applications able to cover all the main industries Applications Industries Applications TOF GCxGC TOF GC DHS TD HSS Analyzers Forensic Flame Retardants X Forensic Drugs X Forensic Blood Alcohol X X X Pharma Residual Solvents X X X Environmental Hydrocarbons X Environmental VOCs in Water X X X Environmental VOCs in Soil X X Environmental VOCs in Air X X Environmental PAHs X X Environmental PCBs X X Environmental Phenols X Environmental Phthalates X Environmental Tracers in Gas X X DANI Instruments

23 in the last 4 years we developed more than one hundred applications able to cover all the main industries Applications Industries Applications TOF GCxGC TOF GC DHS TD HSS Analyzers Chemicals Amines X Chemicals Glycol Ethers X Chemicals Nitrosamines X X Chemicals Dioxane in Water X X Chemicals Acrylonitrile X X Chemicals Nicotine in Tobacco X X Chemicals Ketones X Industrial Hygiene Anaesthetics X X Packaging Residual Solvents X X X Gas Natural Gas X Gas Refinery Gas X Gas LPG X Power Generation TOGA ASTM 3612 C X Oil Oxygenates in Gasoline X Oil Aromatics in Gasoline X DANI Instruments

24 MASTER GC Fast Gas Chromatograph

25 Why MASTER GC MASTER in speed repeatability and split flow linearity sample introduction sensitivity selectivity data acquisition accessibility flexibility modularity easy to use complete solutions design

26 Master in speed DANI MASTER GC is able to dramatically decrease sample run times in a wide range of GC applications. Faster than a conventional GC, DANI MASTER GC increases your analytical productivity with an excellent sensitivity. Necessary for Fast GC High oven temperature rates High carrier gas pressures Fast Detectors Short and narrow columns (typically 5-15m long and 0.1mm internal diameter) DANI MASTER GC is a Fast GC MASTER GC Strengths

27 Hydrocarbons Oil Index ISO [mv] 250 Fast GC Total time 5 min Conventional GC Total time 20 min 200 Voltage Time [min.] MASTER GC FAST GC

28 Polyaromatic Hydrocarbons (PAHs) Fast GC Total time < 10 min Conventional GC Total time 27 min Peak Identification 1 Naphthalene 2 Acenaphthylene 3 Acenaphthene 4 Fluorene 5 Phenanthrene 6 Anthracene 7 Fluoranthene 8 Pyrene 9 Benzo (a) Anthracene 10 Chrysene 11 Benzo (b) fluoranthene 12 Benzo (k) fluoranthene 13 Benzo (a) pyrene 14 Indeno (1,2,3-cd) pyrene 15 Dibenzo (a,h) Anthracene 16 Benzo (ghi) perylene MASTER GC FAST GC

29 Fatty Acid Methyl Esters (FAME) Conventional GC Total time 50 min Fast GC Total time < 13 min MASTER GC FAST GC

30 Master in repeatability and split flow linearity A patent pending Digital Flow Control (DFC) combined with a digital control of oven temperature, assures an unsurpassed and verified repeatability and split flow linearity in both conventional and in fast gas chromatography. Retention Time SD C C C C C C C C C C C Oven temperature program: 50 C, 1min, 140 C/min, 70 C, 95 C/min, 115 C, 70 C/min,175 C, 50 C/min, 300 C, 35 C/min, 350 C 25 Repetitions MASTER GC Strengths

31 Master in sample introduction DANI MASTER GC supports a complete range of injectors such as the DANI PTV that ensures unprecedented sample integrity and supports the stringent timing requirements of FAST GC through a rapid cool down. Advantages DANI PTV, with its high heating speed rate and wide range of uses, is Eliminates needle discrimination Reduces Discrimination effect Reduces solvent volume injected Large volume injection Split and Splitless operations High retention time and area precision No thermal degradation the best injector in the world Effects Great repeatability mainly for manual injection Sample Integrity Negligible Solvent Peak Increased sensitivity PTV performances are better than a Split-Splitless injector keeping the same flexibility Great repeatability vs. SL/IN Injector Ideal for thermolabile compounds Operative conditions independent from oven Increased sensitivity for low boiling compounds Reduced risk of contamination Easier handling, easier automation Glass Liner NO precolumn needed (On-Column) Mainly vs. On-Column injector MASTER GC Strengths

32 Injection technique Split-Splitless On-Column PTV Split x - x Splitless x - Cold on column - x x Solvent split - Large volume - x (modified) x (modified) x x SPME x (modified) - x PTV Injector Strengths

33 Discrimination Effect comparison between split/splitless injector and PTV PTV Injector Strengths

34 1,40 1,20 1,00 0,80 0,60 0,40 PTV Split-splitless 0,20 0,00 C12 C16 C20 C24 C26 C32 C36 C40 Repeatability comparison between split/splitless injector and PTV PTV Injector Strengths

35 Solvent Split injection eliminated peak distortions due to solvent PTV Injector Strengths

36 Master in sensitivity FID Detector DANI MASTER GC features a full range of highly sensitive detectors. Each detector includes a Digital Pressure Control (DPC) which allows digital setting of the detector gas flow rates. MASTER GC Linear Dynamic Range > 10 6 Low Detection Limits Data Acquisition Range < 1.6 pg carbon/sec 300 Hz GC Conditions Column: CarboWax 30m, 0,32mm Inj: SL/IN 350 C Det: FID 350 C Carrier: He Voltage [mv] benzene toluene ethylbenzene m-xylene o-xylene VOCs - BTEX analysis TD Conditions Trap: Tenax GR Tube: Tenax GR Sample Volume: 1000ml Minimum detectable level: 0.1 ppb p-xylene Time [min.] MASTER GC Strengths

37 Master in sensitivity ECD Detector DANI MASTER GC features a full range of highly sensitive detectors. Each detector includes a Digital Pressure Control (DPC) which allows digital setting of the detector gas flow rates. MASTER GC Linear Dynamic Range > 10 4 Low Detection Limits Data Acquisition Range < 6 fg/sec lindane 300 Hz GC Conditions Organochlorine Pesticides using FAST ECD Detector Oven: 100 C, 30 C/min., 290 C Inj: SL/IN 300 C Carrier: He 0.5 ml/min Split: 50ml/min Det: ECD 320 C Sensitivity S/ N= 480 0,05 ppm split 1:10 MDL= 0,4 ppb Acquisition = 250 Hz MASTER GC Strengths

38 FPD Detector MASTER GC Linear Dynamic Range S > 10 3 P > 10 4 Master in selectivity Low Detection Limits Data Acquisition Range <40 pg sulphur/sec as dodecanethiol <0.4 pg phosphorous/sec as tributylphosphate 300 Hz DANI selective detectors specifically eliminate matrix interferences while providing maximum sensitivity. DANI comprehensive line of detectors guarantees a cost-effective solution to your application requirements. GC Conditions Phosphorous Pesticides using FAST FPD Detector Oven: 100 C, 40 C/min., 290 C Inj: SL/IN 300 C Det: FPD 230 C / 130 C Carrier: He 0.5 ml/min Split: 50ml/min split 1:100, S/N = 34 acquisition 250Hz MDL=0.05 ppb MASTER GC Strengths

39 Master in selectivity NPD Detector MASTER GC Linear Dynamic Range > 10 4 Low Detection Limits Data Acquisition Range <0.6 pg nitrogen/sec as azobenzene <0.1 pg phosphorous/sec as malathion 300 Hz DANI selective detectors specifically eliminate matrix interferences while providing maximum sensitivity. DANI comprehensive line of detectors guarantees a cost-effective solution to your application requirements. GC Conditions Oven: 100 C, 40 C/min., 290 C Inj: SL/IN 300 C Det: NPD 300 C Carrier: He 0.5 ml/min Split: 50ml/min Nitrogen / Phosphorous Pesticides using FAST NPD Detector Sensitivity S/ N = 270 0,05 ppm split 1:50 Acquisition = 250 Hz MDL= 0.5 ppb MASTER GC Strengths

40 Master in data acquisition The detectors data acquisition rate is up to 300 Hz for better reproducibility and accuracy of chromatographic signals. Detector FID ECD NPD FPD TCD micro TCD PID Data Acquisition Range 300 Hz 300 Hz 300 Hz 300 Hz 300 Hz 300 Hz 300 Hz MASTER GC Strengths

41 Master in accessibility An easy to the complete system allows a simple maintenance and an effective cost reduction. Master in flexibility Gas sampling valves, auxiliary ovens, switching valves and other optional devices make DANI MASTER GC the most suitable gas chromatograph for the development of complex analytical systems in a wide range of applications. Master in modularity Modular design of system components allows to quickly change or upgrade GC configurations with ease. DANI MASTER GC allows up to three injection units and three detectors installed simultaneously. MASTER GC Strengths

42 Master in easy to use An intuitive Touch Screen interface controls both the GC and AS with an ultimate simplicity. MASTER GC Strengths

43 Master in easy to use A light inside the oven simplifies column installation. MASTER GC Strengths

44 Master in complete solutions DANI MASTER GC with Headspace Sampler DANI HSS 86.50, Thermal Desorber DANI MASTER TD and the new MASTER DHS Dynamic Headspace Sampler cover a wide range of applications in environmental, chemicals, petrochemicals, pharmaceutical, food and beverages fields. The DANI MASTER GC coupled with the autosampler DANI MASTER AS is the right answer for the automation of your laboratory. 3 Application and Configuration Books More than 100 applications MASTER GC Strengths

45 FAST Gas Chromatograph (Oven, Injectors, Detectors) SPEED Gas Chromatograph (Oven) NO DISCRIMINATION Gas Chromatograph (PTV) FLOW Gas Chromatograph (DFC Digital Flow Control) SENSITIVE Gas Chromatograph (Detectors) TOUCH Gas Chromatograph (Touch Screen) MODULAR Gas Chromatograph FLEXIBLE Gas Chromatograph (Valves, Methanizers) COMPLETE Gas Chromatograph (Samplers) EASY Gas Chromatograph (Oven Light) MASTER GC Selling Points

46 DANI Instruments HSS Technical Presentation Massimo Cazzaniga DANI Instruments S.p.A.

47 HSS Head Space Sampler

48 Indirect method to analyze volatile compounds in liquid or solid samples. Analysis of vapor phase in thermodynamic equilibrium with the sample, in a closed system. Head Space Technique

49 K= Cc/Cg Partition coefficient Equilibrium After equilibration, a part of the headspace gas is statically sampled by means of a loop or a syringe. Head Space Technique

50 Influence of heating time D[X] G 0 Equilibrium Condition Degradation [X] G T Heating Time Working at equilibrium means an higher sensitivity and an higher accuracy of the measure. Head Space Technique

51 When the sample matrix can not be directly injected solid sample complex matrix viscous or corrosive matrix i.e. : soil, plastics, fuel oil, fruit peel, paste When it is used

52 Clean technique Little or no sample preparation Analysis of substances that can not be directly injected into GC More sensitive than liquid injection Reduced or absent solvent peak Gas chromatographic columns life increasing Quantitative and good precision technique Benefits of Head Space Analysis

53 Automatic Sampling Sample equilibration Pressurization Venting (Sample loop filling) Injection Sampling phases

54 STEP 1: PRESSURIZATION VENT CARRIER AUXILIARY GAS LOOP MANIFOLD TO GC OVEN SAMPLE VIAL Sampling phases

55 STEP 2: VENTING VENT CARRIER AUXILIARY GAS LOOP MANIFOLD TO GC OVEN SAMPLE VIAL Sampling phases

56 STEP 3: INJECTION VENT CARRIER AUXILIARY GAS LOOP MANIFOLD TO GC OVEN SAMPLE VIAL Sampling phases

57 Carrier gas flow rate high enough to avoid peak broadening Auxiliary gas pressure high enough to completely fill the loop Higher auxiliary gas pressure will result in a useless sample dilution and lower sensitivity Gas optimization

58 Constant incubation time

59 VCM in PVC resin Styrene in polymer Ethylene in PET Ethylene Oxide in sterilized material Residual volatile solvents in pharmaceutical Residual volatile solvents in packaging MHE - Applications

60 Solvents in Blood MEK 2. Benzene 3. MIBK 4. Toluene 5. MNBK 6. Ethylbenzene 7. p-xylene 8. 1-Butanol (ISTD) 9. o-xylene 10. Styrene Time (min) HSS Applications

61 Residual volatile solvents in pharmaceutical Methylene Chloride 2. Chloroform 2 3. Benzene 4. Trichloroethylene 5. Dioxane 5 Standard solution at concentration corresponding to the maximum allowable USP limits for 100 mg sample HSS Applications

62 Drinking Water Analysis ECD PID Static Headspace + PTV focusing HSS Applications

63 Anaesthetics in biological fluids 4 1. Nitrous Oxide 2. Enflurane 2 3. Isoflurane 4. Halotane 1 3 HSS Applications

64 Determination of dioxane in water Sample: Dioxane in water 10ppm GAS CHROMATOGRAPH PARAMETERS HEAD SPACE SAMPLER PARAMETERS Oven: 50 C, 4 min, 25 C/min, 200 C, 3 min Injector: SL/IN, 180 C Carrier gas: Helium, 10 ml/min, constant flow Injection mode: split, split flow 10 ml/min, split ratio 1:1 Detector: FID, 250 C Column: DN-WAX, 10 m, 0.53 mm, 1.20 µm Manifold: 150 C Oven: 85 C Transfer Line: 150 C Incubation Time: 10min.

65 Determination of residual solvents in food packaging using STATIC Headspace Peak Identification 1 ethanol 2 isopropanol 3 ethylacetate 4 metossipropanol 5 n-propilacetate 6 acetyl acetone 7 butylcellosolve Sample: 0.5 dm2 GAS CHROMATOGRAPH PARAMETERS HEAD SPACE SAMPLER PARAMETERS Oven: 50 C, 5min, 5 C/min, 100 C, 1min, 10 C/min, 230 C Injector: SL/IN, 250 C Carrier gas: Helium, 1.5 ml/min Split: 30 ml/min Detector: FID, 280 C Column: DN m 0.32mm 1.80 µm Manifold: 130 C Oven: 125 C Transfer Line: 150 C Incubation Time: 30min

66 Determination of BTX and Styrene in water using static headspace [mv ] Voltage benzene toluene etylbenzene p-xylene m-xylene o-xylene styrene Sample: BTX and Styrene in water 10 ppb [min.] Time GAS CHROMATOGRAPH PARAMETERS HEAD SPACE SAMPLER PARAMETERS Oven: 40 C, 5 C/min, 110 C, 5 min, 20 C/min., 200 C Injector: SL/IN, 150 C Carrier gas: Helium, 10 ml/min, constant flow Injection mode: split, split flow 10 ml/min, split ratio 1:1 Detector: FID, 250 C Column: DN-WAX, 25m, 0.53 mm, 1.2 µm Manifold: 85 C Oven: 75 C Transfer Line: 85 C Incubation Time: 30min.

67 Determination of residual solvents in radiopharmaceuticals using Head Space sampling technique According to USP 467 HEAD SPACE SAMPLER PARAMETERS GAS CHROMATOGRAPH PARAMETERS Oven: 50 C - 1 min - 20 C/min - 85 C - 5min - 20 C/min C Injector: SL/IN, 250 C Carrier gas: Helium, 2 ml/min Injection mode: split, split ratio 1:40 Detector: FID, 300 C Column: DN-WAX, 25 m, 0.25 mm, 0.25 µm Manifold: 95 C Oven: 95 C Transfer Line: 95 C Incubation Time: 30min. Aux Gas: He 0.7 bar Vent: 10 sec Sampling: 10 sec Press: 10 sec Sample: 5 ml

68 DETERMINATION OF BLOOD ALCOHOL ALC 1 Methanol Acethaldehyde Ethanol 2-propanol Acetone +Acetonitrile MEK Ethyl acetate press-fit FID 1 column 1 FID 2 ALC 2 Acethaldehyde Methanol Ethanol Acetone 2-propanol Acetonitrile Ethyl acetate MEK HSS Conditions Oven: 60 C Manifold: 70 C Tube: 80 C Press: 11.8 psi Incubation time:15 min. GC Conditions Oven: 35 C column 2 Inj: SL/IN 150 C Det: FID 300 C Carrier: He 18.8 psi Split: 1:5

69 Plastic industry Acetaldehyde determination in polymers Pharmaceutical industry Residual volatile solvents in pharmaceutical Food industry Flavours in food Clinical chemistry Alcohols and organics in biological fluids Industrial quality control Ethylene oxide in sterilized products Environmental Volatile pollutants in water and soil HSS Fields of application

70 HSS Sampling Method Valve&Loop Sample Capacity 44 Sample Vials 20ml or 10ml Sampling Device Temperature 45 C to 200 C Sample Pathway inert deactivated Sampling Volume 0,5 1 3 ml Incubation Oven Sample Capacity 6 Incubation Oven Temperature 40 C to 200 C Incubation Oven Time 1 to 300 min Vials Shaking Off, Slow and Fast Transfer Line Temperature 50 C to 220 C Transfer Line system inert deactivated Constant Heating Time YES Overlapping Sample Processing YES HSS Specifications

71 HSS Automatic parameter increment Valve YES electrically actuated Methods stored 4 Dimensions Weight Power supply 420x474x617mm (WxHxD) 32Kg 220V (± 10%), 50Hz, 600VA Environmental conditions temperature C humidity 0-95% HSS Specifications

72 What do you need for your analysis?

73 TRANSFER LINE NEEDLES Description Set of Code Transfer Line needle - 0.7x0.4 Puntale Linea di Trasferimento - 0.7x0.4 Transfer Line needle - 0.5x0.2 Puntale Linea di Trasferimento - 0.5x0.2 2 pieces 2 pezzi 2 pieces 2 pezzi HSS HSS HSS HSS

74 HEAD SPACE VIALS Description Set of Code Vial 23x46 volume 10 ml crimp top Vial 23x46 volume 10 ml chiusura a capsula Vial 23x46 volume 10 ml crimp top Vial 23x46 volume 10 ml chiusura a capsula Vial 23x75 volume 20 ml crimp top Vial 23x75 volume 20 ml chiusura a capsula Vial 23x75 volume 20 ml crimp top Vial 23x75 volume 20 ml chiusura a capsula Crimp seal AL for Vial 23x46 and 23x75 Capsula AL per Vial 23x46 and 23x75 Crimp seal AL for Vial 23x46 and 23x75 Capsula AL per Vial 23x46 and 23x75 Septa TFE/BUT for crimp seal cod Setto TFE/BUT per Capsula cod Septa TFE/BUT for crimp seal cod Setto TFE/BUT per Capsula cod Septa TFE/SIL for crimp seal cod Setto TFE/SIL per Capsula cod Septa BUT for crimp seal cod Setto BUT per Capsula cod pieces 50 pezzi 500 pieces 500 pezzi 50 pieces 50 pezzi 500 pieces 500 pezzi 100 pieces 100 pezzi 500 pieces 500 pezzi 100 pieces 100 pezzi 500 pieces 500 pezzi 100 pieces 100 pezzi 100 pieces 100 pezzi HSS HSS HSS HSS HSS HSS SPT HSS HSS SPT HSS HSS SPT HSS HSS SPT HSS HSS SPT HSS HSS SPT HSS HSS SPT HSS HSS SPT

75 Description Set of Code Hand Crimper for crimp seal cod Pinza Chiudi Vials per Capsula cod Vials extractor for Vial 23x75 Estrattore per Vial 23x75 Tray adapter for Vial volume 10 ml Adattatore per Vial volume 10 ml portacampioni esterno Incubation Oven adapter for Vial volume 10 ml Adattatore per Vial volume 10 ml camera incubazione 1 piece 1 pezzo 1 piece 1 pezzo 25 pieces 25 pezzi 6 pieces 6 pezzi HSS HSS SPT SPT HSS HSS HSS HSS

76 International Sales Meeting April 5 th 6 th 2011 Static Headspace Sampler SHS The Authentic Static Haedspace Sampler Ilaria Ferrante GC Product Manager

77 Static Headspace Sampler SHS The FIRST universal headspace OVER three-decades of experience THE HEADSPACE s NAME IS OVER Headspace produced Hystorically DANI The Best!

78 Static Headspace Sampler SHS MASTER SHS designed with our customer in mind flexible system to meet all needs robust and trouble free design

79 Why a Static Headspace Sampler? Static Headspace Sampler SHS ROBUST & FLEXIBLE TECNIQUE PROVEN & SENSITIVE TECHNIQUE UNIVERSAL COMPATIBILITY OUTSTANDING REPRODUCIBILITY Why a Static Headspace Sampler? HIGHEST PRODUCTIVITY ACCURACY & DATA TRACEABILITY ENVIROMENTALLY SAFE

80 Static Head Space Sampler SHS Static HeadSpace sampling technique is the most commonly used technique for the analysis of volatile and semivolatile compounds ROBUST & FLEXIBLE TECHNIQUE

81 SHS Static Head Space Sampler Sample flow path is entirely chemical inert ( Silconert 2000) Eliminated analytical carryover High temperature headspace sampler (300 C) Working at equilibrium means an higher sensitivity and a higher accuracy of the measure PROVEN SENSITIVE TECHNIQUE

82 Static Head Space Sampler SHS Valve & Loop is the most reliable and robust technique Compact manifold design ensures maximum thermal control Carrier gas flow rate is uninterruptedly maintained OUTSTANDING REPRODUCIBILITY

83 Static Head Space Sampler SHS VENT CARRIER AUXILIARY GAS LOOP MANIFOLD TO GC OVEN SAMPLE VIAL Sampling phases STEP 1: Shaking Leak Check Pressurization OUTSTANDING REPRODUCIBILITY

84 Static Head Space Sampler SHS VENT CARRIER AUXILIARY GAS LOOP MANIFOLD TO GC OVEN SAMPLE VIAL Sampling phases STEP 2: Venting OUTSTANDING REPRODUCIBILITY

85 Static Head Space Sampler SHS VENT CARRIER AUXILIARY GAS LOOP MANIFOLD TO GC OVEN SAMPLE VIAL Sampling phases STEP 3: Injection OUTSTANDING REPRODUCIBILITY

86 Static Head Space Sampler SHS Up to 120 vial positions 18 vials oven capacity for maximized sample throughput Unilimited priority vial Maximum compatibility with headspace vials of 10 ml, 20 ml, 22 ml to meet every application need HIGHEST PRODUCTIVITY

87 Static Head Space Sampler SHS NO need of External Standard Multiple HeadSpace Extraction (MHE) Quantitative method for complex matrices that eliminates sample matrix effect and allows to obtain the total peak area proportional to the total amount of analyte of the original sample and a consequent more precise quantization. HIGHEST PRODUCTIVITY

88 Static Head Space Sampler SHS Sample too diluited Multiple HeadSpace Injection (MHI) allows a multiple valve&loop injection in a proper programmable temperature injector filled with dedicated sorbent material in order to improve the analytical system sensitivity. HIGHEST PRODUCTIVITY

89 Static Head Space Sampler SHS New Analisys Method Method Development Optimization (MDO) any single method can be associated with an optimization procedure, in which the value of a selected parameter is automatically incremented of a constant amount in a series of consecutive samplings of identical samples. Oven temperature and incubation time can be optimized separately. HIGHEST PRODUCTIVITY

90 Static Head Space Sampler SHS Bar Code Reader guarantees sample ratification and validation, assuring data traceability Automatic Leak Check procedure ensures the proper pressurization and the perfect seal of each vial Sample tray cooling device preserves sample integrity CFR 21 Part 11 compliance ACCURACY & DATA TRACEABILITY

91 Static Head Space Sampler SHS Full controlled by Touch Scrren and SHS Manager SW or Clarity data station. ACCURACY & DATA TRACEABILITY

92 Static Head Space Sampler SHS IQ OQ / PQ Procedure [V] Voltage 1,0 0,8 0,6 Dichlorobenzene Nitrobenzene 2,52 2,71 0,4 0,2 0, Time [min.] Example of analysis with SL/IN - FID configuration ACCURACY & DATA TRACEABILITY

93 Static Head Space Sampler SHS Easy connection with any kind of GC or GCMS system UNIVERSAL COMPATIBILITY

94 Static Head Space Sampler SHS Headspace sampling technique is a Totally Green procedure, there is no need of solvents Gas Saving Function Time & Energy Saving Function Two separate pneumatic circuit for Auxiliary and carrier gas ENVIROMENTALLY SAFE

95 Static Headspace Sampler SHS WIDE RANGE OF APPLICATIONS Limited or no sample preparation No contamination risk Reduced inlet and column maintenance Analysis of substances that can not be directly injected into GC It is a very flexible technique suitable for solid and liquid sample matrices

96 Static Headspace Sampler SHS FORENSIC PHARMACEUTICAL ENVIRONMENTAL PACKAGING FOOD & BEVERAGE POLYMERS BIODIESEL

97 Static Headspace Sampler SHS DETERMINATION OF BLOOD ALCOHOL ALC 1 Methanol Acethaldehyde Ethanol 2-propanol Acetone+ Acetonitrile MEK Ethyl acetate ALC 2 Acethaldehyde Methanol Ethanol Acetone 2-propanol Acetonitrile Ethyl acetate MEK Master SHS Conditions Oven: 60 C Manifold: 70 C Tube: 80 C Press: 11.8 psi Incubation time:15 min. Master GC GC Conditions Oven: 35 C Inj: SL/IN 150 C Det: FID 300 C Carrier: He 18.8 psi Split: 1:5 FORENSIC

98 Static Headspace Sampler SHS DETERMINATION OF BLOOD ALCOHOL response (mv x s) Ethanol Linearity R 2 = 0,9995 Carryover Calculated DB-ALC1 = 0.006% DB-ALC2= 0.012% LOD = 93 ppb concentration (ppm) FORENSIC

99 Static Headspace Sampler SHS RESIDUAL VOLATILE SOLVENTS IN PHARMACEUTICAL USP 467 PHARMACEUTICAL

100 Static Headspace Sampler SHS RESIDUAL VOLATILE SOLVENTS IN PHARMACEUTICAL USP 467 Master SHS complies with USP 467 method where is specifically required a Headspace system. PHARMACEUTICAL

101 Static Headspace Sampler SHS DETERMINATION OF BTEX AND STYRENE IN WATER Master SHS Conditions Oven: 60 C Manifold: 70 C Tube: 80 C Press: 11.8 psi Incubation time:15 min. GC Conditions Oven: 35 C Inj: SL/IN 150 C Det: FID 300 C Carrier: He 18.8 psi Split: 1:5 ENVIRONMENTAL

102 Static Headspace Sampler SHS DETERMINATION OF BTEX AND STYRENE IN WATER benzene toluene ethylbenzene p-xylene m-xylene o-xylene styrene average 22,02 26,04 28,65 28,67 29,28 24,94 20,38 devstd 0,28 0,20 0,41 0,34 0,25 0,27 0,19 RSD% 1,27 0,77 1,43 1,19 0,86 1,07 0,92 ENVIRONMENTAL

103 Static Headspace Sampler SHS DETERMINATION OF BTEX AND STYRENE IN WATER EPA Method Compliance Master SHS is perfectly compliances with EPA Method where is required a Headspace system. Preparative method EPA 5021 ( EPA 624, EPA 8260, etc.) Analitycal method EPA 8021 ENVIRONMENTAL

104 Static Headspace Sampler SHS RESIDUAL SOLVENTS IN FOOD PACKAGING 1 Methanol 2 Ethanol 3 2-Propanol 4 Acetone 5 Methylacetate 6 1-propanol 7 Sec-Butanol 8 2-Butanone 9 Ethylacetate 10 Isobutanol 11 THF 12 2-Methoxyethanol 13 Cyclohexane 14 isoproylacetate 15 n-butanol 16 1-Methoxy-2-propanol 17 n-propylacetate 18 2-Ethoxyethanol 19 4-Methyl2pentanone 20 Isobutylacetate 21 Toluene 22 n-butyl acetate 23 Methylcellosolveacetate 24 2-Etoxyethylacetate 25 Cyclohexanone PACKAGING

105 Static Headspace Sampler SHS RESIDUAL SOLVENTS IN FOOD PACKAGING R2 Methanol 1,0000 Ethanol 0, Propanol 0,9948 Acetone 0,9967 Methylacetate 0, propanol 0,9973 Sec-Butanol 0, Butanone 0,9905 Ethylacetate 0,9989 Isobutanol 0,9939 THF 0, Methoxyethanol 0,9994 Cyclohexane 0,9990 isoproylacetate 1,0000 n-butanol 0, Methoxy-2-propanol 0,9871 n-propylacetate 0, Ethoxyethanol 0, Methyl2pentanone 0,9993 Isobutylacetate 0,9977 Toluene 0,9971 n-butyl acetate 0,9950 Methylcellosolveacetate 0, Etoxyethylacetate 0,9716 Cyclohexanone 0,9978 PACKAGING

106 Static Headspace Sampler SHS FRUIT FRAGRANCES Strawberries Profile 9gr of sample in 10ml vial Master SHS Conditions Oven: 60 C Manifold: 150 C TrLine: 190 C Press: 0.64bar Incubation time:60 min. FOOD & BEVERAGE

107 Static Headspace Sampler SHS FRUIT FRAGRANCES Banana Profile 6gr of sample in 10ml vial Master SHS Conditions Oven: 60 C Manifold: 150 C TrLine: 190 C Press: 0.64bar Incubation time:60 min. FOOD & BEVERAGE

108 Static Headspace Sampler UNI EN ISO 14110: 2003 SHS GAS CHROMATOGRAPH PARAMETERS Oven: 70 C, 20 min Injector: SL/IN 150 C Carrier gas: Helium, 1 ml/min, constant flow Injection mode: split, 50ml/min. Detector: FID, 150 C Column: DN-BioDiesel : 30 m, 0.32 mm, 1 µm Sample: standard mixture of methanol 0,1% + 5ul of 2-propanol Master SHS PARAMETERS Oven: 80 C Manifold: 80 C Incubation Time: 45 min. Aux Gas: 1 bar Vent: 10 sec Sampling: 10sec. Press: 10sec. BIODIESEL

109 CONCLUSIONS The most used technique in the field of VOC analisys Utilized for liquid and solid sample Easy to use Fully automated Versatile MASTER SHS THE DANI SOLUTION FOR HEADSPACE ANALIYSIS CONCLUSIONS

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