Research Article Preparation, Characterization and Cross-linking of Chitosan by Microwave Assisted Synthesis

Transcription

1 OPEN ACCESS Science International ISSN DOI: /sciintl Research Article Preparation, Characterization and Cross-linking of Chitosan by Microwave Assisted Synthesis Sindhu Abraham, Deveswaran Rajamanickam and Bharath Srinivasan Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, MSRIT Post, Bangalore, India

2 $ E E

3 E Y = b0+b1x1+b2x2+b3x3+... W2-W1 % Swelling index 100 W1

4 Ci-Cf % Cross-linking index 100 Ci C E C E EG

5 % Swelling in acidic ph = A B C AC BC X1 = A: Concentration of vanillin X2 = B: Microwave power Actual factor C: Microwave time = 3 % Swelling in acidic ph B: Microwave power (%) A: Concentration of vanillin (%)

6 X1 = A: Concentration of vanillin X2 = B: Microwave power Actual factor C: Microwave time = Swelling in acidic ph (%) B: Microwave power (%) A: Concentration of vanillin (%) % Swelling in basic ph = A B+2.63 C AB AC BC A B C2

7 (a) Transmittance (%) (b) (c) Wavenumber (cmg 1 1/cm ) G G G G G

8 (a) ppm (b) ppm ppm (c) ppm ppm

9 0.5 (a) _Sindhu_Abraham_Chitosan_cpmas-1-11.jdf Cross polarization Absorbance X: parts per million: carbon (b) _Sindhu_Abraham_Chitosan_cpmas-1-9.jdf Cross polarization Absorbance X: parts per million: carbon 13

10 E E (a) File name: D:\SAIF DATA\2 \SAIFDT150616C-01(CH)stad Operator ID: Sample ID SAIFDT150616C-01(CH) Sample weight: mg Comment: Weight (mg) Heat from C at C min Temperature ( ) 7/9/ :06:44 am Weight (mg) (b) C mg ming 1 File name: D:\SAIF DATA\2 \SAIFDT150616C-01(CH)stad Operator ID: Sample ID SAIFDT150616C-01(CH) Sample weight: mg Comment: Deactivate weight (mg ming 1 ) C mg ming Heat from C at C min Temperature ( ) 7/9/ :08:58 am

11 (c) File name: D:\SAIF \SAIFDT150616C-02(IOTI CV).stad Operator ID: Sample ID SAIFDT150616C-02(OPTI CV)1 Sample weight: mg Comment: Weight (mg) Heat from C at C min Temperature ( ) 7/9/2015 3:58:39 pm (d) File name: D:\SAIF \SAIFDT150616C-02(IOTI CV).stad Operator ID: Sample ID SAIFDT150616C-02(OPTI CV)1 Sample weight: mg Comment: Weight (mg) Deactivate weight (mg ming 1 ) C mg ming C mg ming Heat from C at C min Temperature ( ) 7/13/2015 4:00:03 pm E E

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