Model Information Data Set. Response Variable (Events) Summe Response Variable (Trials) N Response Distribution Binomial Link Function
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1 02:32 Donnerstag, November 03, Model Information Data Set WORK.EXP Response Variable (Events) Summe Response Variable (Trials) N Response Distribution inomial Link Function Logit Variance Function Default Variance Matrix locked y Trial Estimation Technique Residual PL Degrees of Freedom Method Satterthwaite lass Level Information lass Levels Values Trial 6 I II III IV V VI Dose Strain 7 A D E F ONTROL Number of Observations Read 30 Number of Observations Used 30 Number of Events 3185 Number of Trials 5047 Dimensions G-side ov. Parameters 13 olumns in X 14 olumns in Z per Subject 13 Subjects (locks in V) 6 Max Obs per Subject 9
2 02:32 Donnerstag, November 03, Optimization Information Optimization Technique Dual Quasi-Newton Parameters in Optimization 13 Lower oundaries 13 Upper oundaries 0 Fixed Effects Profiled Starting From Data Iteration Restarts Subiterations Iteration History Objective Function hange Max Gradient onvergence criterion (PONV= E-8) satisfied. Estimated G matrix is not positive definite. Fit Statistics -2 Res Log Pseudo-Likelihood Generalized hi-square Gener. hi-square / DF 0.97
3 02:32 Donnerstag, November 03, ovariance Parameter Estimates ov Parm Subject Group Estimate Intercept Trial Dose*Strain 0 ONTROL Intercept Trial Dose*Strain 2.5 A 0. Intercept Trial Dose*Strain Intercept Trial Dose*Strain Intercept Trial Dose*Strain 2.5 D 0. Intercept Trial Dose*Strain 2.5 E 0. Intercept Trial Dose*Strain 2.5 F Intercept Trial Dose*Strain 5 A 0. Intercept Trial Dose*Strain E-18. Intercept Trial Dose*Strain Intercept Trial Dose*Strain 5 D 0. Intercept Trial Dose*Strain 5 E 0. Intercept Trial Dose*Strain 5 F Effect Type III Tests of Fixed Effects Num DF Den DF F Value Pr > F Dose*Strain
4 02:32 Donnerstag, November 03, Solution for Random Effects Effect Subject Group Estimate Std Err Pred Intercept Trial I Dose*Strain 0 ONTROL Intercept Trial I Dose*Strain 2.5 A Intercept Trial I Dose*Strain Intercept Trial I Dose*Strain Intercept Trial I Dose*Strain 2.5 D Intercept Trial I Dose*Strain 2.5 E Intercept Trial I Dose*Strain 2.5 F Intercept Trial I Dose*Strain 5 A Intercept Trial I Dose*Strain Intercept Trial I Dose*Strain Intercept Trial I Dose*Strain 5 D Intercept Trial I Dose*Strain 5 E Intercept Trial I Dose*Strain 5 F Intercept Trial II Dose*Strain 0 ONTROL Intercept Trial II Dose*Strain 2.5 A Intercept Trial II Dose*Strain Intercept Trial II Dose*Strain Intercept Trial II Dose*Strain 2.5 D Intercept Trial II Dose*Strain 2.5 E Intercept Trial II Dose*Strain 2.5 F Intercept Trial II Dose*Strain 5 A Intercept Trial II Dose*Strain Intercept Trial II Dose*Strain Intercept Trial II Dose*Strain 5 D Intercept Trial II Dose*Strain 5 E Intercept Trial II Dose*Strain 5 F Intercept Trial III Dose*Strain 0 ONTROL Intercept Trial III Dose*Strain 2.5 A Intercept Trial III Dose*Strain Intercept Trial III Dose*Strain Intercept Trial III Dose*Strain 2.5 D Intercept Trial III Dose*Strain 2.5 E Intercept Trial III Dose*Strain 2.5 F Intercept Trial III Dose*Strain 5 A 0....
5 02:32 Donnerstag, November 03, Solution for Random Effects Effect Subject Group Estimate Std Err Pred Intercept Trial III Dose*Strain Intercept Trial III Dose*Strain Intercept Trial III Dose*Strain 5 D Intercept Trial III Dose*Strain 5 E Intercept Trial III Dose*Strain 5 F Intercept Trial IV Dose*Strain 0 ONTROL Intercept Trial IV Dose*Strain 2.5 A Intercept Trial IV Dose*Strain Intercept Trial IV Dose*Strain Intercept Trial IV Dose*Strain 2.5 D Intercept Trial IV Dose*Strain 2.5 E Intercept Trial IV Dose*Strain 2.5 F Intercept Trial IV Dose*Strain 5 A Intercept Trial IV Dose*Strain Intercept Trial IV Dose*Strain Intercept Trial IV Dose*Strain 5 D Intercept Trial IV Dose*Strain 5 E Intercept Trial IV Dose*Strain 5 F Intercept Trial V Dose*Strain 0 ONTROL Intercept Trial V Dose*Strain 2.5 A Intercept Trial V Dose*Strain Intercept Trial V Dose*Strain Intercept Trial V Dose*Strain 2.5 D Intercept Trial V Dose*Strain 2.5 E Intercept Trial V Dose*Strain 2.5 F Intercept Trial V Dose*Strain 5 A Intercept Trial V Dose*Strain Intercept Trial V Dose*Strain Intercept Trial V Dose*Strain 5 D Intercept Trial V Dose*Strain 5 E Intercept Trial V Dose*Strain 5 F Intercept Trial VI Dose*Strain 0 ONTROL Intercept Trial VI Dose*Strain 2.5 A Intercept Trial VI Dose*Strain
6 02:32 Donnerstag, November 03, Solution for Random Effects Effect Subject Group Estimate Std Err Pred Intercept Trial VI Dose*Strain Intercept Trial VI Dose*Strain 2.5 D Intercept Trial VI Dose*Strain 2.5 E Intercept Trial VI Dose*Strain 2.5 F Intercept Trial VI Dose*Strain 5 A Intercept Trial VI Dose*Strain Intercept Trial VI Dose*Strain Intercept Trial VI Dose*Strain 5 D Intercept Trial VI Dose*Strain 5 E Intercept Trial VI Dose*Strain 5 F Strain Dose Estimate Dose*Strain Least Squares Means Mean Mean ONTROL A D E < F A < D E < F Strain Differences of Dose*Strain Least Squares Means Dose _Strain _Dose Estimate ONTROL 0 A ONTROL ONTROL <.0001
7 02:32 Donnerstag, November 03, Strain Differences of Dose*Strain Least Squares Means Dose _Strain _Dose Estimate ONTROL 0 D <.0001 ONTROL 0 E ONTROL 0 F ONTROL 0 A ONTROL <.0001 ONTROL ONTROL 0 D <.0001 ONTROL 0 E ONTROL 0 F <.0001 A A <.0001 A 2.5 D <.0001 A 2.5 E <.0001 A 2.5 F A 2.5 A A <.0001 A <.0001 A 2.5 D <.0001 A 2.5 E A 2.5 F < D E F A D E F D E < F A < D
8 02:32 Donnerstag, November 03, Strain Differences of Dose*Strain Least Squares Means Dose _Strain _Dose Estimate 2.5 E < F D 2.5 E <.0001 D 2.5 F D 2.5 A <.0001 D D D 2.5 D D 2.5 E <.0001 D 2.5 F E 2.5 F E 2.5 A <.0001 E <.0001 E <.0001 E 2.5 D <.0001 E 2.5 E E 2.5 F <.0001 F 2.5 A F F F 2.5 D F 2.5 E F 2.5 F A <.0001 A <.0001 A 5 D <.0001 A 5 E A 5 F < D E < F D E < F D 5 E <.0001
9 02:32 Donnerstag, November 03, Strain Differences of Dose*Strain Least Squares Means Dose _Strain _Dose Estimate D 5 F E 5 F <.0001
10 02:32 Donnerstag, November 03, onservative T Grouping for Dose*Strain Least Squares Means (Alpha=0.05) LS-means with the same letter are not significantly different. Strain Dose Estimate A F A A A A A A A F A D D A A ONTROL E E D The LINES display does not reflect all significant comparisons. The following additional pairs are significantly different: (5,5 ), (2.5,0 ONTROL), (5,5 A), (5,2.5 A), (5,0 ONTROL), (5,5 E), (2.5 F,5 A), (2.5 F,2.5 A), (2.5 F,0 ONTROL), (2.5 F,5 E), (2.5,5 A), (2.5,2.5 A), (2.5,0 ONTROL), (2.5,5 E), (2.5 D,5 A), (2.5 D,2.5 A)...
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