Molecular Weights and Residue Weights of Protected Amino Acids

Transcription

1 Molecular Weights and Residue Weights of Protected Amino Acids Amino Acid Boc Derivative M.W. Residue Wt. in Protected Peptide hain Fmoc Derivative M.W. Residue Wt. in Protected Peptide hain Alanine Boc-Ala Fmoc-Ala Arginine Boc-Arg(Tos) Fmoc-Arg(Mtr) Boc-Arg(Mts) Fmoc-Arg(Pmc) 66 4 Asparagine Boc-Asn 114 Fmoc-Asn Fmoc-Asn(Mbh) Fmoc-Asn(Trt) Aspartic Acid Boc-Asp(Bzl) 05 Fmoc-Asp(tBu) Boc-Asp(cex) ysteine Boc-ys(4- Bzl) 5 07 Fmoc-ys(tBu) Boc-ys(4- Bzl) 41 Fmoc-ys(Trt) Boc-ys(Acm) Fmoc-ys(Acm) Glutamic Acid Boc-Glu(Bzl) 7 19 Fmoc-Glu(tBu) Boc-Glu(cex) 9 11 Glutamine Boc-Gln Fmoc-Gln Fmoc-Gln(Mbh) Fmoc-Gln(Trt) Glycine Boc-Gly Fmoc-Gly istidine Boc-is(Dnp) 41 0 Fmoc-is(Trt) Boc-is(Bom) Fmoc-is(Bum) Isoleucine Boc-Ile 1 11 Fmoc-Ile 5 11 Leucine Boc-Leu 1 11 Fmoc-Leu 5 11 Lysine Boc-Lys(l-Z) Fmoc-Lys(Boc) Methionine Boc-Met Fmoc-Met Boc-Met() Phenylalanine Boc-Phe Fmoc-Phe Proline Boc-Pro Fmoc-Pro 7 97 erine Boc-er(Bzl) Fmoc-er(tBu) Threonine Boc-Thr(Bzl) Fmoc-Thr(tBu) Tryptophan Boc-Trp Fmoc-Trp Boc-Trp() 14 Tyrosine Boc-Tyr(Br-Z) Fmoc-Tyr(tBu) Valine Boc-Val Fmoc-Val 9 99

2 AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE G Gly glycine MW Boc-Gly- -Boc-glycine MW Fmoc-Gly- -Fmoc-glycine MW 97.1 A V L I P Ala alanine MW Val valine MW Leu leucine MW Ile isoleucine MW Boc-Ala- -Boc-L-alanine MW Boc-Val- -Boc-L-valine MW 17.7 Boc-Leu- -Boc-L-leucine MW 1.9 MW 49.1 ( 0) Boc-Ile- -Boc-L-isoleucine MW 1.9 MW 40.0 (1/ 0) Fmoc-Ala- -Fmoc-L-alanine MW 11.4 Fmoc-Val- -Fmoc-L-valine MW 9.9 Fmoc-Leu- -Fmoc-L-leucine MW 5.4 Fmoc-Ile- -Fmoc-L-isoleucine MW 5.4 Pro proline MW Boc-Pro- -Boc-L-proline MW 15.5 Fmoc-Pro- -Fmoc-L-proline MW 7.8

3 AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE F Phe Boc-Phe- phenylalanine Fmoc-Phe- -Boc-L-phenylalanine MW Fmoc-L-phenylalanine MW 65.1 MW M Boc-Met- -Boc-L-methionine MW 49. Met methionine MW Boc-Met()- -Boc-L-methionine-DL-sulfoxide MW 65. Fmoc-Met- -Fmoc-L-methionine MW W Boc-Trp- -Boc-L-tryptophan MW 04.5 Fmoc-Trp- -Fmoc-L-tryptophan MW Trp tryptophan MW 04. Boc-Trp()- - α-boc--indole-formyl-l-tryptophan MW.6 Fmoc-Trp(Boc)- -Fmoc--indole-Boc-L-tryptophan MW 56.59

4 AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE er serine MW Boc-er(Bzl)- -Boc--benzyl-L-serine MW 95.4 Fmoc-er(tBu)- -Fmoc--t-butyl-L-serine MW 8.44 T Thr threonine MW Boc-Thr(Bzl)- -Boc--benzyl-L-threonine MW 09.6 Fmoc-Thr(tBu)- -Fmoc--t-butyl-L-threonine MW Y Br Tyr tyrosine MW Boc-Tyr(Br-Z)- -Boc--(-bromobenzyloxycarbonyl) -L-tyrosine MW Fmoc-Tyr(tBu)- -Fmoc--t-butyl-L-tyrosine MW

5 AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE ys cysteine MW Boc-ys(4-Bzl)- Boc-ys(MeBzl)- -Boc--4-methylbenzyl-L-cysteine MW 5.4 Fmoc-ys(Trt)- -Fmoc--trityl-L-cysteine MW Boc-ys(4-Bzl)- Boc-ys(Mob)- Boc-ys(Mbzl)- -Boc--p-methoxybenzyl-L-cysteine MW 41.4 Fmoc-ys(tBu)- -Fmoc--t-butyl-L-cysteine MW Boc-ys(Acm)- -Boc--acetamidomethyl-L-cysteine MW 9.5 Fmoc-ys(-tBu)- -Fmoc--t-butylsulfenyl-L-cysteine MW Fmoc-ys(Acm)- -Fmoc--acetamidomethyl-L-cysteine MW

6 AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE Asn asparagine MW 1.1 Boc-Asn- - α-boc-l-asparagine MW.4 Fmoc-Asn- - α-fmoc-l-asparagine MW 54.6 Boc-Asn(Xan)- - α-boc-- β-xanthyl-l-asparagine MW Fmoc-Asn(Mbh)- - α-fmoc-- β-(dimethoxybenzhydryl)- L-asparagine MW Mbh also known as: Dod = dimethoxydityl Ddm = dimethoxydiphenylmethyl Fmoc-Asn(Trt)- - α-fmoc-- β-(trityl)-l-asparagine MW

7 Q AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE Gln Boc-Gln- Fmoc-Gln- - -Fmoc-L-glutamine glutamine - α -Boc-L-glutamine α MW 68.9 MW MW 46.6 Boc-Gln(Xan)- - α-boc-- γ -xanthyl-l-glutamine MW Fmoc-Gln(Mbh)- - α-fmoc-- γ -(dimethoxybenzhydryl)-l-glutamine MW Mbh also known as: Dod = dimethoxydityl Ddm = Dimethoxydiphenylmethyl Fmoc-Gln(Trt)- - α-fmoc-- γ-(trityl)-l-glutamine MW 610.7

8 D AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE Asp aspartic acid MW l.l0 Boc-Asp(Bzl)- -Boc-L-aspartic acid- β -benzyl ester MW.5 Fmoc-Asp(tBu)- -Fmoc-L-aspartic acid- β-t-butyl ester MW Boc-Asp(cex)- -Boc-L-aspartic acid- β-cyclohexyl ester MW 15.7 E Glu glutamic acid MW Boc-Glu(Bzl)- -Boc-L-glutamic acid- γ -benzyl ester MW 7.7 Fmoc-Glu(tBu)- -Fmoc-L-glutamic acid- γ-t-butyl ester MW Boc-Glu(cex)- -Boc-L-glutamic acid- γ-cyclohexyl ester MW 9.9

9 AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE is histidine MW Boc-is(Dnp)- - α-boc--im-dinitrophenyl-l-histidine MW 41.8 Fmoc-is(Trt)- - α-fmoc--im-dinitrophenyl-l-histidine MW Boc-is(πBom)- -α-boc--π-benzyloxymethyl-l-histidine MW 75.4 Boc-is(Z)- -α--boc--im-benzyloxycarbonyl-l-histidine MW Fmoc-is(Fmoc)- -α---im-bis-fmoc-l-histidine MW Fmoc-is(πBum)- -α--fmoc--π-butyloxymethyl-l-histidine MW Boc-is(Tos)- -α--boc--im-tosyl-l-histidine MW MW (DA)

10 K R AMI AID B PRTETED DERIVATIVE FM PRTETED DERIVATIVE Lys lysine MW l Boc-Lys(l-Z)- Fmoc-Lys(Boc)- - α-boc-- ε-(-chlorobenzyloxycarbonyl)-l-lysine - α-fmoc-- ε -Boc-L-lysine MW MW Arg arginine MW Boc-Arg(Tos)- G - α-boc- -tosyl-l-arginine MW Fmoc-Arg(Mtr)- G - α-fmoc- -(4-methoxy-,,6- trimethylbenzenesulfonyl)-l-arginine MW (IPE) Boc-Arg(Mts)- G - α-boc- -(mesitylene--sulfonyl)-l-arginine MW Fmoc-Arg(Pmc)- G - α-fmoc- -(,,5,7,8-pentamethylchroman- 6-sulfonyl)-L-arginine MW 66.81