Breast module: all stages

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1 Breast module: all stages Characteristics of the sample Version of the QLQ-C30 v v v v 3.0 1, Total 2,782 Age < Not known Total 2,782 Stage Stage I-II Stage III-IV Recurrent/metastatic 1, Not known Total 2,782 Mean (SD) Median [IQR] Body image BRBI 82.7 (22.9) 91.7 [ ] Sexual functioning BRSEF 19.5 (22.8) 16.7 [0-33.3] Sexual enjoyment BRSEE 53.1 (27.1) 66.7 [ ] Future perspective BRFU 47.3 (33.7) 66.7 [ ] Systemic therapy BRCT 15.5 (13.5) 14.3 [ ] Breast systems BRRT 16.2 (16.8) 8.3 [0-25] Arm symptoms BRSY 18.7 (20.5) 11.1 [0-33.3] Hair loss BRHL 5.0 (18.2) 0 [0-0] 295

2 Breast module: all stages BRBI BRRT Total 977 Total 972 BRSEF BRSY Total BRCT Total 1, Total

3 Breast module: all stages Single Items Not at all A little Quite a bit Very much Total N 1) Dry mouth BRCT ,012 2) Food and drink BRCT ,014 3) Painful eyes BRCT ,010 4) Lost hair BRCT ,004 5) Upset by hair loss BRHL ) Feel ill or unwell BRCT ) Hot flushes BRCT ,003 8) Headaches BRCT ,006 9) Less attractive BRBI Less feminine BRBI ) Look at self naked BRBI ,007 12) Dissatisfied with body BRBI ) Worried about health BRFU ,008 14) Interested in sex BRSEF ) Sexually active BRSEF ) Sex enjoyable BRSEE ) Pain in arm or shoulder BRSY ,010 18) Swollen arm or hand BRSY ,011 19) Difficulty raising arm BRSY ,011 20) Pain in breast BRRT ,003 21) Breast swollen BRRT ) Breast oversensitive BRRT ) Skin problems BRRT ,

4 Breast module: <50 Characteristics of the sample Version of the QLQ-C30 v v v v Total 936 Age < Not known 0 0 Total 936 Stage Stage I-II Stage III-IV Recurrent/metastatic Not known Total 936 Mean (SD) Median [IQR] Body image BRBI 81.3 (23.3) 91.7 [ ] Sexual functioning BRSEF 26.7 (24.2) 33.3 [0-33.3] Sexual enjoyment BRSEE 55.2 (27.1) 66.7 [ ] Future perspective BRFU 37.9 (33.2) 33.3 [0-66.7] Systemic therapy BRCT 15.3 (13) 14.3 [ ] Breast systems BRRT 14.9 (15.4) 8.3 [0-25] Arm symptoms BRSY 15.7 (17.9) 11.1 [0-22.2] Hair loss BRHL 4.3 (16.7) 0 [0-0] 298

5 Breast module: <50 BRBI BRRT Total 358 Total 354 BRSEF BRSY Total BRCT Total Total

6 Breast module: <50 Single Items Not at all A little Quite a bit Very much Total N 1) Dry mouth BRCT ) Food and drink BRCT ) Painful eyes BRCT ) Lost hair BRCT ) Upset by hair loss BRHL Insufficient data available 6) Feel ill or unwell BRCT ) Hot flushes BRCT ) Headaches BRCT ) Less attractive BRBI Less feminine BRBI ) Look at self naked BRBI ) Dissatisfied with body BRBI ) Worried about health BRFU ) Interested in sex BRSEF ) Sexually active BRSEF ) Sex enjoyable BRSEE ) Pain in arm or shoulder BRSY ) Swollen arm or hand BRSY ) Difficulty raising arm BRSY ) Pain in breast BRRT ) Breast swollen BRRT ) Breast oversensitive BRRT ) Skin problems BRRT

7 Breast module: Characteristics of the sample Version of the QLQ-C30 v v v v Total 786 Stage Stage I-II Stage III-IV Recurrent/metastatic Not known Total 786 Mean (SD) Median [IQR] Body image BRBI 80.5 (24) 91.7 [ ] Sexual functioning BRSEF 20.7 (22.6) 16.7 [0-33.3] Sexual enjoyment BRSEE 51.9 (26.8) 66.7 [ ] Future perspective BRFU 49.4 (31.8) 66.7 [ ] Systemic therapy BRCT 16.0 (12.9) 14.3 [ ] Breast systems BRRT 17.1 (17.2) 16.7 [4.2-25] Arm symptoms BRSY 21.1 (22.2) 11.1 [0-33.3] Hair loss BRHL 4.5 (17.5) 0 [0-0] 301

8 Breast module: BRBI BRRT Total 304 Total 300 BRSEF BRSY Total BRCT Total Total

9 Breast module: Single Items Not at all A little Quite a bit Very much Total N 1) Dry mouth BRCT ) Food and drink BRCT ) Painful eyes BRCT ) Lost hair BRCT ) Upset by hair loss BRHL Insufficient data available 6) Feel ill or unwell BRCT ) Hot flushes BRCT ) Headaches BRCT ) Less attractive BRBI Less feminine BRBI ) Look at self naked BRBI ) Dissatisfied with body BRBI ) Worried about health BRFU ) Interested in sex BRSEF ) Sexually active BRSEF ) Sex enjoyable BRSEE ) Pain in arm or shoulder BRSY ) Swollen arm or hand BRSY ) Difficulty raising arm BRSY ) Pain in breast BRRT ) Breast swollen BRRT ) Breast oversensitive BRRT ) Skin problems BRRT

10 Breast module: Characteristics of the sample Version of the QLQ-C30 v v v v Total 523 Stage Stage I-II Stage III-IV Recurrent/metastatic Not known Total 523 Mean (SD) Median [IQR] Body image BRBI 85.0 (21.7) 100 [75-100] Sexual functioning BRSEF 11.3 (17.8) 0 [0-33.3] Sexual enjoyment BRSEE 49.1 (25.8) 33.3 [ ] Future perspective BRFU 52.4 (34.3) 66.7 [ ] Systemic therapy BRCT 16.0 (14.6) 14.3 [ ] Breast systems BRRT 16.2 (16.9) 8.3 [0-25] Arm symptoms BRSY 20.8 (21.9) 11.1 [0-33.3] Hair loss BRHL 7.3 (21.6) 0 [0-0] 304

11 Breast module: BRBI BRRT Total 226 Total 228 BRSEF BRSY Total BRCT Total Total

12 Breast module: Single Items Not at all A little Quite a bit Very much Total N 1) Dry mouth BRCT ) Food and drink BRCT ) Painful eyes BRCT ) Lost hair BRCT ) Upset by hair loss BRHL Insufficient data available 6) Feel ill or unwell BRCT ) Hot flushes BRCT ) Headaches BRCT ) Less attractive BRBI Less feminine BRBI ) Look at self naked BRBI ) Dissatisfied with body BRBI ) Worried about health BRFU ) Interested in sex BRSEF ) Sexually active BRSEF ) Sex enjoyable BRSEE Insufficient data available 17) Pain in arm or shoulder BRSY ) Swollen arm or hand BRSY ) Difficulty raising arm BRSY ) Pain in breast BRRT ) Breast swollen BRRT ) Breast oversensitive BRRT ) Skin problems BRRT

13 Breast module: recurrent/metastatic Characteristics of the sample Version of the QLQ-C30 v v v v Total 1,147 Age < Not known Total 1,147 Mean (SD) Median [IQR] Body image BRBI 81.9 (22.6) 91.7 [ ] Sexual functioning BRSEF 19.2 (23.2) 0 [0-33.3] Sexual enjoyment BRSEE 55.1 (25.6) 66.7 [ ] Future perspective BRFU 47.6 (34.1) 66.7 [ ] Systemic therapy BRCT 15.8 (14.3) 14.3 [ ] Breast systems BRRT 17.6 (17.4) 16.7 [0-25] Arm symptoms BRSY 21.0 (21.1) 22.2 [0-33.3] Hair loss BRHL 5.3 (19.3) 0 [0-0] 307

14 Breast module: recurrent/metastatic BRBI BRRT Total 605 Total 599 BRSEF BRSY Total BRCT Total Total

15 Breast module: recurrent/metastatic Single Items Not at all A little Quite a bit Very much Total N 1) Dry mouth BRCT ) Food and drink BRCT ) Painful eyes BRCT ) Lost hair BRCT ) Upset by hair loss BRHL ) Feel ill or unwell BRCT ) Hot flushes BRCT ) Headaches BRCT ) Less attractive BRBI Less feminine BRBI ) Look at self naked BRBI ) Dissatisfied with body BRBI ) Worried about health BRFU ) Interested in sex BRSEF ) Sexually active BRSEF ) Sex enjoyable BRSEE ) Pain in arm or shoulder BRSY ) Swollen arm or hand BRSY ) Difficulty raising arm BRSY ) Pain in breast BRRT ) Breast swollen BRRT ) Breast oversensitive BRRT ) Skin problems BRRT

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