Corporate Presentation

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1 Corporate Presentation

2 In a few words Contract Development & Manufacturing Organization Focused on key pharmaceuticals niches Independent company 32,8% owned by Management / 67,2% Private Equity funds Growing company 250 million Euros in 2015 and 1150 staffs Global company Products sold in more than 85 countries (USA / China / etc. ) Worldwide leader on BFS technology 2.2 Billion doses manufactured in 2015 Liquid Stick-pack pioneer Capacity of 260 Million liquid Stick-packs

3 History 1993 Acquisition of Amiens plant 1997 Start of Export activities 2005 Acquisition of Créapharm 2007 BFS Transfer from Boehringer Ingelheim 2011 FDA Inspection of Coutances plant 2013 Acquisition of Rochester Plant (NY USA) ANVISA approval of Coutances plant 2015 Acquisition of Barretos Plant (SP Brazil) 1995 Focus on BFS technology 2002 Acquisition of Coutances Plant 2006 Launch of UNISTICK 2008 Acquisition of Colomiers plant 2011 Creation Commercial Office Unither do Brasil (Sao Paulo)

4 Equity Management Private equity funds 32,8 67,2 Private Equity Funds Equistone Parquest CMCIC Finance Picardie Investissements

5 Effectifs Sales & Employees Ventes (en M ) Année Effectif Ventes

6 Global organization 5 Manufacturing sites Amiens France Colomiers France Coutances France Gannat France Rochester USA Barretos Brazil Production Commercial Office 1 R&D center Bordeaux France Rochester, NY USA 3 Commercial Offices Paris France Rochester USA Sao Paulo - Brazil Barretos BRAZIL Sao Paulo BRAZIL

7 BFS Amiens France Coutances France Rochester USA Liquid Stick-Pack Colomiers France Rochester USA Global organization Production Commercial Office Bottles Colomiers France Rochester USA Rochester, NY USA Powder Stick-Pack Gannat France Barretos BRAZIL Effervescent Tablets Gannat France Sao Paulo BRAZIL Pharmaceutical Development Bordeaux France

8 TECHNOLOGIES Dedicated sites AMIENS France COUTANCES France COLOMIERS France GANNAT France PLANT m2 300 Staff of EU GMP / ISO m2 200 Staff of FDA / EU GMP / ISO m2 230 Staff of EU GMP / ISO m2 120 Staff of EU GMP / ISO BFS (Sterile unit Doses) Liquid Stick-Pack Powder Stick-Pack Bottles Effervescent tablets EQUIPMENTS 10 BP Rotative 3 BP Alternative 1,5 Billion SDU / Year 8 BP Rotative 1 Billion SDU / Year 2 Stick-Pack Lines 250 Million Sticks / Year 5 Bottle Lines 50 Million bottles / Year Effervescent Line Powder Stick-Pack Line 450 Million tablets / Year DEVELOPMENT 1 Dedicated team 1 Pilot workshop 1 Dedicated team 1 Pilot workshop (2015) 1 Dedicated team 1 Pilot workshop 1 Dedicated team 1 Pilot workshop

9 TECHNOLOGIES ROCHESTER NY, USA BARRETOS São Paulo, Brazil BORDEAUX France PLANT BFS (Sterile unit Doses) m2 200 Staff of FDA GMP & EU m2 126 Staff of ANVISA GMP m2 50 Staff of European GMP / ISO Liquid Stick-Pack Powder Stick-Pack Bottles Effervescent tablets Development Clinical batches EQUIPMENTS Liquid Stick-Pack Line 1 BP Rotative line Bottle lines Capsules fillers & tablets presses Liquid Stick-Pack Line 4 Bottle lines 2 Stick-Pack lines 8 tablets presses & capsules fillers Dry forms Primary packaging Drug delivery systems DEVELOPMENT 1 Dedicated team 1 Pilot workshop 1 Dedicated team 1 Pilot workshop Formulation Validation Analytics Stability studies Quality control

10 Amiens - France TECHNOLOGY BFS (Sterile unit Doses) PLANT m2 300 Staff of 3 & 5 shifts European GMP / ISO EQUIPMENTS 10 BP Rotative 3 BP Alternative 1,5 Billion SDU / Year Development 1 dedicated team 1 Pilot workshop

11 Coutances - France TECHNOLOGY BFS (Sterile unit Doses) PLANT m2 200 Staff of 3 & 5 shifts FDA / European GMP / ISO EQUIPMENTS 8 BP Rotative 1 Billion SDU / Year Development 1 dedicated team 1 pilot workshop (2015)

12 Colomiers - France TECHNOLOGY Liquid Stick-Pack Bottles PLANT m2 230 Staff of 2, 3 & 5 shifts European GMP / ISO EQUIPMENTS 3 Stick-Pack Line 250 Million Sticks / Year 5 Bottle Lines 50 Million bottles / Year Development 1 dedicated team 1 Pilot workshop

13 Gannat - France TECHNOLOGY Effervescent tablets Powder Stick-Pack PLANT m2 100 Staff of 2 & 3 shifts European GMP / ISO EQUIPMENT Effervescent Line Powder Stick-Packs Line 450 Million tablets / Year Development 1 dedicated team

14 Rochester - USA TECHNOLOGY BFS (Sterile unit Doses) Liquid Stick-Pack Bottles / Powder PLANT m2 200 Staff of US & European GMP EQUIPMENT Liquid Stick-Pack Line 1 BP Rotative line 2 Bottle lines/tablets presses & capsules fillers Development 1 dedicated team 1 Pilot workshop

15 Barretos São Paulo Brazil TECHNOLOGY Liquid Stick-Pack Bottles / Powder Vitamins PLANT m2 126 Staff of ANVISA GMP EQUIPMENT Liquid Stick-Pack Line 4 Bottle lines 2 Stick-Pack lines 8 tablets presses & capsules fillers Development 1 dedicated team

16 R&D center Pharmaceutical Development Clinical batches Bordeaux - France Plant 1800 m2 50 Persons European GMP / ISO Formulation and Chimical Batches Dry forms Primary Packaging Drug delivery systems Analytic Development Validation ICH Stability Quality Control

17 Our Mission To deliver to our customers Innovative Solutions Focus on key pharmaceuticals niches Competitive Solutions Dual Business Model Substainable Solutions Partnership

18 Collaboration type Dual Business model Contract Development and Manufacturing Organization for strategy outsourcing Turn-key products & Dossiers for licensing in

19 Our Technologies Liquid Stick-Pack Technology Blow-Fill-Seal Technology CONSULTING PHARMACEUTICAL DEVELOPMENT Powder Stick-Pack Technology Bottle Technology INNOVATIVE SOLUTIONS MANUFACTURING Effervescent tablet Technology

20 Thanks You

21 Unither Pharmaceuticals 41 rue de la Chaussée d Antin, PARIS, France Tel

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