Patient Donor. Male Female. Load Position: D-mix Lot #/Batch # Read by Date (384-Well Format Only) H G F

Transcription

1 *SSPJPN_007R* Cat #SSPJPN Patient Donor Male Female Race ABO/Rh Sample I.D. Birthdate Relationship to Patient Disease DNA Extraction Method DNA Concentration Taq Lot # Results Comments: (For Tray Exp. Date Test Performed by Date multi-test trays) Tray Dot # Load Position: D-mix Lot #/Batch # Read by Date (384-Well Format Only) 3 9 Load Position: Reviewed by Date 6 2 Test No. Test No.: H G F E D C B A Tray Position Photo Documentation Well # bps Well # bps Well # bps Well # bps Well # bps Well # bps Well # bps Well # bps Well # bps Well # bps Well # bps Well # bps / / / / / / / / 22 2 / / / / / / / / Notes on bps: Well# 2 (G): 0 / 7 / 200 / 22 / 20 Well# (D): 7 / 200 / 22 Well# 29 (4D): 7 / 200 / 22 Well# 79 (0B): 00 / 2 / 0 / 27 / 32 Well# 83 (F): 0 / 7 / 200 / 22 The allele nomenclature includes the HLA alleles listed in the July 20 update of the IMGT/HLA database release 3.2. (Robinson J, et al., "IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex" Nucleic Acids Research (2003), 3, 3-34). Complete update information is located at Revision summary: July 20 nomenclature update based on IMGT/HLA database version (D) C*06:2 was added to the primer specificity to better define its reactivity. SSP-JAPN-007-WS-00 REV : PAGE OF 33

2 (7B) Bw6 (w/o B*07:3; B*07:97; B*07:0; B*07:79; B*07:92; B*07:9; B*07:244; B*08:29; B*08:36; B*08:97; B*08:0; B*08:4; B*08:3; B*08:36; B*08:39; B*4:0:0; B*4:02:0; B*4:02:08; B*4:30; B*4:34; B*:0:2; B*:0:27; B*:277; B*:3; B*:34; B*8:0:2; B*8:4; B*8:99; B*3:0:39; B*3:02:03; B*3:7:02; B*3:2; B*3:222; B*3:248; B*3:293; B*39:0:; B*39:24:02; B*39:00; B*39:04; B*39:0; B*40:0:3; B*40:02:22; B*40:76; B*40:27; B*40:3; B*40:93; B*40:22; B*40:27; B*40:28; B*40:223; B*40:28; B*40:306; B*4:02:02; B*4:0; B*4:26; B*4:6; B*46:48; B*48:20; B*48:36; B*0:38; B*4:0:0; B*4:0:02; B*4:0:03; B*4:0:04; B*4:0:0; B*4:0:06; B*4:0:07; B*4:02; B*4:03; B*4:04; B*4:06; B*4:07; B*4:09; B*4:0; B*4:; B*4:3; B*4:4; B*4:; B*4:6; B*4:7; B*4:8; B*4:9; B*4:20; B*4:2; B*4:22; B*4:23; B*4:24; B*4:2; B*4:26; B*4:27; B*4:28; B*4:29; B*4:30; B*4:3; B*4:32; B*4:33; B*4:34; B*:0:3; B*:73; B*6:07; B*6:2; B*67:02; B*8:06): B*07:02:0~2/4~26/28~3/37/39~80/82~96:02/98~09/N~48/0~78/8N~9/93~94/96~28/220~23/237~243/24~26; B*08:0:0~0:3/04~28/30N~3/37~/3:0~66/68~77/79~96/98~00/02~3/~6/8~2/27~30/32~3/37~38/40~; B*3:09/39/67; B*4:0:0~0:04/0:06~02:04/02:06~02:07/02:09~29/3~33/3~49; B*:0:0:0~0:24/0:26/0:28~2/4~/8:0~2/2:0~3/37~42/44~66/68~86/88/90~94N/96~4/6~6/8~6/63~67/69~76/78~9/97~207/209N~2/27~22/223~229/23~23/2 /27~267/269~272N/274~276/278~30/32~338/340~33/3/37~360/363; B*8:0:0:0~0:20/0:22~08/0~44:02/46~3/~66/68~98/00~3; B*27:08/2/8/26/33/40/42/44/89; B*3:0:0:0~0:38/0:40~02:02/02:04~7:0/8~/3~72/74~22/223~247/249~292/294~296; B*37:0//37; B*39:0:0:0~0:4/0:6~24:0/2N~99/0~02; B*40:0:0~0:30/0:32~02:2/02:23~2/4:0~8/20~46/48~7/77~9/97~08/~6/8N~26/28~34/36~6/8~87/89~92/94~200/202~2/23~26N/29~222/224~280/282~29N/293 ~30/307~309; B*4:0:0~02:0/02:03~04/06~2/27~39; B*42:0:0~2; B*44:09/46/7/90/29/3; B*4:0:0~; B*46:0:0~47/49~64; B*47:02; B*48:0:0~7/9/2~3/37; B*0:0:0~37/39~43; B*:0:0~0:2/0:4~7/74~7; B*6:0:0:0~06/08~20:02/22~4/47~49; B*7:2; B*8:64; B*67:0:0~0:03/03~0; B*73:0~02; B*78:0:0~08; B*8:0~0/07; B*82:0~03; B*83:0 (7C) Bw4 (w/o B*3:28; B*27:0:2; B*27:49; B*27:6; B*27:22; B*37:24; B*44:03:6; B*44:; B*44:27; B*44:4; B*44:72; B*44:200; B*49:2; B*:0:4; B*:67; B*:9; B*:7; B*2:0:9; B*2:04; B*2:34; B*2:3; B*3:0; B*7:0:08; B*7:08; B*7:34; B*8:42; B*8:4): B*07:27/36/38/8/49/80/29/236; B*08:02~03/2/78/7/26; B*3:0:0~08/0~27/29~38/40~66/68~84; B*:3:0~3:02/6:0~7:03/23~24:02/36/43/67/87/89/9//7/62/68/77/96/208/26/222/230/24/26/268/273/339/36/36~362; B*8:09/4/67; B*27:0~0:24/0:26~07:04/09~/3~7/9~2/27~32/34~39/4/43/4~48/0:0~88/90:0~/7~2/23~42; B*37:0:0~04:02/06:0~0/2~23/2~36/38~6; B*38:0:0~7; B*40:3/9/47/96/09~0/7/7/88/20/292; B*44:02:0:0~03:/03:7~08/0~4/47~74/76~89/9~0/2~26:02/28/30/32~44/46~7N/73~99/20~223; B*47:0:0:0~0:02/03~0; B*48:8; B*49:0:0~20/22~39; B*:0:0:0~0:3/0:~66/68~09/~8:02/60~70/72~90; B*2:0:0:0~0:8/0:20~03/0~33/36~0; B*3:0:0~09/~39; B*4:2; B*6:07/2/46; B*7:0:0~0:07/0:09~07/09~/3~33/3~79N; B*8:0:0:0~4/43~3/~63/6~72N; B*9:0:0:0~09 (9F) C*03:274, C*04:94, C*07:40, C*7:27N were removed from the primer specificity to better define its reactivity. Allele sequences are obtained from the IMGT database. Updates, including modifications to allele sequences may alter bead specificity. This tray is intended for low resolution HLA typing results. Typing results outside this specification may produce ambiguities that require additional testing to resolve. The following alleles are not included in this kit: None C*02:08 and C*02:42 are not within the target loci of this kit, but share the same reaction pattern as A*30:4. The reaction pattern table has been modified to group C*02:08/42 with A*30:4. C*6:8 shares the same reaction pattern as B*27:04:02 et al. The reaction pattern table has been modified to group C*6:8 with B*27:04:02~04:03/0:06/0:08~0:09/0:~0:7/0:9~0:22/0:24/0:26~0:30//27~28/3/39/4~46/48/0:0~/4~6/8~6/64N/70~74/78~80/82/84~88/90:0~9/93~94N/96:0/97~0/03~ 0/07~08/20~2/23~24/29/32~33/3/37~38/40~42; B*44:64:0~64:02; B*47:0:0:0~0:02/04~0; B*7:3/9/30. SSP-JAPN-007-WS-00 REV : PAGE 2 OF 33

3 A Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent A Locus Allele Group A*0:0:0:0~0:/ 0:3~0:4/0:6~0:6/ 0:67~09/N/4~6N/8N/ A, A"Blank", A- 20/22N~2/27N/29/3N~0/ 2N~7/73~78/80~94/96~98/ 00~0/03~3/37~42/ 44/46~66/68~89 A- A*0:3 3 8 A- A*0:43 0 A- A*0:7; A*03:8 3 A- A*0:28 8 A- A*0: 6 A- A*0:9 A2, A2"Low", A-, A203, A*02:0:0:0~49/~4/ 7~72/74:0~76:0/77/ 79:0~02/04~2/23~ 2 A20, A"Blank" 27/29~34/36~/7~ 242/244/246~333/33~337/ 339~80; A*03:89 A*02:22; A*68:0:0:0~ 04/06~4/6~9/2:0~28/ A-, A68, A28, A"Blank" 30~4/47/49N/~83/8~ 3 08/0~6/8~28/30~ 34 A- A*02:3 2 7 A- A*02:243:0~243: A-, A2 A*02:0/73/6/24/334/ A- A*02: 2 6 A- A*02:6:0~6:02/ A3, A"Blank", A- A*03:0:0:0~0:03/ 0:0~07/09~N/3~7:02/ 9~22:02/2~28/30~3/33/ 3/37~40/42~8/60~62/64~ 69N/7/73~74/76~87/90~ 3 06/09~/3~70/73~ 7/77~97N/99~204/206~ 209/2~28/22~229; A*30:; A*74:3 A- A*03:7 3 3 A- A*03:20; A*29:4/8; A*3: A- A*03: A- A*03:29; A*32:7 3 A- A*03:63; A*:99:0~ 99:02/ A- A*03:7 3 SSP-JAPN-007-WS-00 REV : PAGE 3 OF 33

4 A Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent A Locus Allele Group A-, A, A"Blank", A34, A66 A-, A66, A0 A*03:88; A*:0:0:0~ 0:0/0:2~02:0/02:03~ 0/07~/3~6/9~39/4~ 42/44/46~6/8~0/2~ N/7~38/4~7/60~ 77/79~89/9~98/200~ 22; A*34:0:0~08/0N~2; A*66:0:02/0; A*69:02; A*80:02 A*:6/40; A*66:0:0/ 0:03/04~09/3~/7~20/ 22~ A-, A9 A*:39; A*24:9/44 8 A-, A32, A"Blank" A*:78/90; A*32:0:0~ 0:20/0:22~4/6/8~38/ 40~4/43~49/2~70/72~74 A- A*: A- A*:7/8 8 3 A23, A-, A"Blank" A*23:0:0~0:2/0:4~ 08N/0~3/~23/2~27/29~ 33/3~6/8~62/64~6/67~ 4 69; A*24:24 A23 A*23:0:3 2 4 A- A*23:09/28 4 A- A*23:4:0~4:02; A*24:7 4 A- A*23: A24, A24"Low", A-, A2403, A*24:02:0:0~02:0/ 02:07~02:7/02:9~3:02/ ~8/20~23/2~43/4N~0/ 3~6/8~63/66~70/72~76/ 78~80/82~9/9~04/06~ A"Blank", A9, A36 9/2~37/39~87/89~ 90/92~22/223~227/229~ 232N/234~290/292~308/ 30:0~34; A*3:08; A*33:2/3; A*36:03 A24 A*24:02:06/02:8 2 A- A*24:309 7 A- A*24:77/9 A2, A-, A"Blank", A26, A43 A*2:0:0~0/07~7/ 9:0~32; A*26:07:0~ 07:02/9/3/72/76/92; A*43:0; A*66:~2 7 SSP-JAPN-007-WS-00 REV : PAGE 4 OF 33

5 A Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent A Locus Allele Group A*26:0:0:0~0:7/ 0:9~0:20/0:22~0:29/ A26, A0, A-, A"Blank" 0:3~06/08/0~8/20~28/ 30/32~33/3~39/4~48/0~ 6 7 7N/74~7/77~90/93~02/ 04~2/4~6 A26 A*26:0: A26, A- A*26:0:2/09/29/34/40/ 49/73/9/03/3 6 A26 A*26:0: A29, A"Blank", A- A*29:0:0:0~06/08N~3/ ~7/9/2~29/3~33/3~ 36/38/40~47/0/2~/7~ 4 72/7~80 A- A*29:07/ A- A*29: A- A*29:/ A30, A-, A30"Low", A"Blank" A*30:0:0~0:07/0:09~ 06/08~:02/4L~/7/9~ 20/23~30/32~40/42~43/4/ 47~4/6~9N/6~94 A- A*30:07/3/6/22/44/ A-, Cw2, C- A*30:4; C*02:08/42 7 A3, A"Blank", A- A*3:0:02:0~0:22/ 0:24~02/04~06/09/~20/ 0 22~23/2~28/30~88/90~98 A- A*3: A-, A3 A*3:07/0; A*32:42 0 A- A*3: A- A*3: A- A*32:39 7 A- A*32: 7 A33, A-, A9, A"Blank" A*33:0:0~2/4~8:02/ 20/22~23/2~47/49~0/2/ 4~60/62~68/70~8/87~9/ 2 93~02 A- A*33:3/ A- A*33:9 2 A- A*33: A- A*33:6 7 2 A- A*33: A68, A- A*68:0//20/46/84/ A- A*68:29 9 SSP-JAPN-007-WS-00 REV : PAGE OF 33

6 C Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent C Locus Allele Group C*0:02:0~03/0~6/8~ Cw, C-, C"Blank" 20/22/24~42/44~47/49~3/ 6N~72/76~89N/9~96/98N~ 6 0/03~N C- C*0:04/4/97/02; C*4: C- C*0:7/ C- C*0: C- C*0: C- C*0: C- C*0: 6 9 C- C*0:73 6 C- C*0: Cw2, C-, C"Blank" C*02:02:0~02:2/02:27~ 0:03/07/09~/3/~20/ 22/24~2Q/27:0~32/34~3/ 37~40:02/44~48/0~4/6~ /63~67Q/69~74/76~86/88~ 93/9~00/02~06; C*:; C*6:34 C*02:02:26/2/26:0~ 26:03/0; C*03:02:3/ Cw2, C-, Cw0, Cw3 04:07/04:27/4/40:02/ 4:0~4:02/87:0/94/0/ 60 3/263/293; C*:02:0/ 02:7/06:02/7/43/99 C- C*02:06/ A-, Cw2, C- A*30:4; C*02:08/42 7 C- C*02:2/ C- C*02:4:0~4: C- C*02: C- C*02: C- C*02:49; C*04::0~:03/ 7/23/37/60/74/80/00/ /78 C- C*02: C- C*02: C- C*02:7; C*6:26/46/ 6 C-, Cw8, C"Blank" C*02:87; C*08:0:0~04:03/ 06~07/09/~2/4~:02/ 7/20/22~24/26N~27/29~ 36N/38~0/2N~4/6~67/ 69~93/9~00/02~04/06~ 2/~23 C- C*02: SSP-JAPN-007-WS-00 REV : PAGE 6 OF 33

7 C Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A 9 Serology Equivalent C Locus Allele Group Cw0, C-, Cw3, C"Blank" C*03:02:0~02:2/02:4/ 04:0:0~04:06/04:08~ 04:7/04:9~04:26/04:28~ 04:37/04:39~0/7/9/23~ 26/28~29/33~3/40:0/ 40:04/42/44/46~48//4/ 7/63/6/70~74/78/82/84/ 87:02/89~93/9/98/00~ 0/04~06/08~09// 4~/7~8/2N/23/ 2/28~29/3/34~3/ 38~40/43/4~49/3~ 7/9/62/64/66/69Q~ 70/72~74/78~8/83~ 84:02/86:0~86:02/90~ 9/93~94/97~20N/ 208N~23/2~26/28~29/ 22~222/224N~226/232~236/ 238~240/244Q~24/247~20/ 22/2~29/26/264~266/ 269~270/277N~279/282~283/ 286/292/294 C*03:03:0~03:04/03:06~ 03:20/03:22~03:29/:0~ 3:02/8:02/20N/22Q/30~ 3/43:0/49~0/2~3/~ 6/9/6~62/66/68/7~76/ 79/8/83/8/88/96~97/03/ Cw9, C-, Cw3, C"Blank" 2/6:0~6:02/20/ 22/24/26~27/32~33/ 8 9 4/0/2/8/60~6/ 67~68/7/7~77/8/ 88~89N/92/96/202~207/ 27/223/227~230/237/24~ 243/23~24/262/268/27~ 276/284~28/288~29 Cw9 C*03:03: Cw9, Cw0, C- C*03:03:2/04:38/8:0/ 32/37:0~37:02/4/60/ 64:0~64:02/07/44/9/ 8 29 Cw0, Cw3 C*03:04:8/40: C- C*03: C- C*03:/36/ C- C*03:6; C*4:4; C*: C- C*03: C- C*03: C- C*03:2/ C- C*03: C- C*03: SSP-JAPN-007-WS-00 REV : PAGE 7 OF 33

8 C Locus 3 4 H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent C Locus Allele Group C- C*03:27/38:0~38:02/30/ 63/ C- C*03: C- C*03: C- C*03: C- C*03:36/ Cw3 C*03: C- C*03:43:02/8/86/02/9/ /6/24/220/2/267; 9 C*8:09 C- C*03: C- C*03: C- C*03: Cw4, C-, C"Blank" C*04:0:0:0~0:09/ 0:/0:3~0:20/0:22/ 0:24~03:0/04:0~09N/3~ 4/6/8~20/24~26/28/30~ 32/3/38~4/43~/3/7~ 9Q/6~70/72~73/7~76/78~ /8~99/0~06/09~/ 3~N/7~28/3~33/ 3~2/4~68/70N~7/ 73N~77/79~86/89~ 9N/93/9~206 Cw4, C- C*04:0:0/0:2/0:23/ 27/33/2/6/30/ Cw4, C- C*04:0:2/03:02/0/2/ 6/34/3/92/ C- C*04: C- C*04:/ 9 68 C- C*04: C- C*04: C- C*04:69; C*: C- C*04: C- C*04: C- C*04: C- C*04: C- C*04: C- C*04:42:0~42: C- C*04:4; C*06:76:02; C*2:28/32/3/ C- C*04: C- C*04: Cw, C-, C"Blank" C*0:0:0:0~0:27/ 0:29~03/0~9/2~24/27~ 28/3/33~3/37~4/44:0~ 4/47~7/9~63/6~69/7~ 62 9N/93~02/04~22; C*08:0 C- C*0:04:0~04:02/03; C*2:2/ C- C*0: C- C*0: C- C*0: C- C*0: C- C*0: C- C*0: C- C*0:46; C*7: C- C*0:8:0~8: C- C*0:64:0~64: C- C*0: SSP-JAPN-007-WS-00 REV : PAGE 8 OF 33

9 C Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent C Locus Allele Group C*06:02:0:0~02:0/ 02:07~02:0/02:3~02:2/ 02:27~02:44/04/06~07/0/ 3/~6N/8~30/32~33/3~ 39/4~43:02/4~8/60~66/ Cw6, C-, C"Blank" 68/70:0~7/73~7/78~84/ ~88/90~9/97~02/04~ 06:02/08~7/9~2/ 23/26~29/3/33~42/ 4~46/48~2N/4~6/ 8~60/62~64 C*06:02:06/02:2/03:0~ 03:02/69/76:0/77/32:0; Cw6, C-, C"Blank" C*2:02:/03:09/03:26/ 0/09/7/49/79/84N/93/97~ 66 98/29; C*4:2/34/6; C*6:40/3 C*06:02:/02:26/08~09/ 2/3/34/9/96/03/07/ Cw6, C- 8/30/44/3/7/6; 63 C*07:76:02/238/328/403/ 406 Cw6 C*06: C- C*06:/22/ C- C*06: C-, C"Blank" C*06:32:02; C*2:02:0~ 02:0/02:2~03:02/03:04~ 03:08/03:0~03:2/03:27~ 04:02/06~07/0:0~3/ 8:0~20/22~27/29~30/32/ 34~43/4~48/0~4/6~78/ 80N/8~92/94~96/99~0N/ ~2/4~8/20~2/ 23~26/28/30~3/33~ 34/36~38/42~43/4/ 48N~0/2~7/9~62; C*4:04/49/64 C- C*06:4/72/ C- C*06: C- C*06: C- C*06: C- C*06: C- C*06: C- C*06: C- C*06: SSP-JAPN-007-WS-00 REV : PAGE 9 OF 33

10 C Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent C Locus Allele Group Cw7, C-, C"Blank" C*07:0:0:0~0:2/ 0:~0:33/0:3~0:40/ 0:42~02:07/02:0~02:28/ 02:30~02:32/02:34~02:40/ 02:42~02:3/02:/02:7~ 03/0~06/08/0/3~2/ 27:0~32N/3~37/4~44/46~ 48/0~62/6~67/70~7/77~ 9/93~9/97~00/03~04N/ 06~23/2~3:02/33~ 36/38/40~4:02/43~ 47/49~/3~4/7~ 60/62~64N/66~76/78~ 80/82~88/90~98N/200~ 209/2~233/23Q~237/239~ 240/243~24/248~266/268~ 27/273~293/297~30/303/ 30~306/308~33/36/38/ 320~32/32~327/330~334/ 337/339~344/346~30N/32~ 33/36/39~360/362~363/ 366~377/379~393N/396~400/ 404/407~43/47~49/42~ 42/427/429~440/442~446 C*07:0:3/0:34/0:4/ 02:08/02:29/02:4/04:0~ 04:0/~2/39~40/4/63/ 68/0/24/42/2N/6/ Cw7, C-, C"Blank" 77/8/89/99:0~ 99:02/234/272/302/39/ ~324/329N/336/338/34/ 34~3/38/364~36/378/ 394~39/40/40/46/420/ 426/428; C*6:2/80 C*07:0:4/02:33/02:4/ 02:6/26/33N/92/96:0~ 96:02/32/246/267/296/ 34:0~34:02/37/322/ Cw7, C-, C"Blank" 4; C*08:2; C*2:03:03/ 4:0~4:02/3/83/06/ 67 9/22/39/4/44// 8; C*6::0~:02/2; C*7:0:0:0~04/06~9/ 2~26/28~30 Cw7 C*07:02: C- C*07:07/09/ C- C*07:0; C*08: C- C*07: C- C*07:37:0~37: C- C*07:48/ C- C*07:6/24/304/307; C*2:6/ C- C*07: C- C*07: C- C*07: C- C*07: C- C*07: Cw7 C*07:38:0~38: C- C*07: C- C*07: C-, Cw7 C*07:49/76:0/3; C*7: C- C*07:64/ SSP-JAPN-007-WS-00 REV : PAGE 0 OF 33

11 C Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A 9 Serology Equivalent C Locus Allele Group C- C*07: C- C*08:0/ C- C*08:08:0~08: C- C*08: C- C*08: C-, Cw8 C*08:9/0 9 6 C- C*08: C- C*08:/4 2 6 C- C*08: C- C*2:08/ C- C*2: C- C*2: C- C*2: C- C*2: C- C*2: C- C*2: C- C*2: C-, C"Blank" C*4:02:0~02:9/0~/ 3~4/6/8~9/2N/23~ 24:02/27~33/36~37/39~40/ ~48/0~2/7/9~60/62/ 6~66/68~69 C-, C"Blank" C*4:03/22/3N/ C- C*4:/7/20/2~26//7 68 C- C*4:38/3~ C- C*4: C- C*4: C-, C"Blank" C*:02:0:0~02:09/ 02:~02:6/02:8~02:24/ 0:0~06:0/06:03~08/3~ /8/2~22/26/28~29/3~ /40~42/44~0/2~60/64~ 73/7~98/00~06/08~09/ ~2/4~7; C*6:70 C- C*: C- C*:04:0~04:02/09/9/ 30/ C- C*:0:0~0:03/3 69 C- C*: C- C*: C- C*: C- C*:24/ C- C*: C- C*: C- C*: C- C*: C- C*: C- C*: C- C*6: SSP-JAPN-007-WS-00 REV : PAGE OF 33

12 C Locus 3 4 H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent C Locus Allele Group B27, B-, B"Blank", B47, C- B*27:04:02~04:03/0:06/ 0:08~0:09/0:~0:7/ 0:9~0:22/0:24/0:26~ 0:30//27~28/3/39/4~ 46/48/0:0~/4~6/8~ 6/64N/70~74/78~80/82/84~ 88/90:0~9/93~94N/96:0/ 97~0/03~0/07~08/ 20~2/23~24/29/32~ 33/3/37~38/40~42; B*44:64:0~64:02; B*47:0:0:0~0:02/04~ 0; B*7:3/9/30; C*6:8 4 C-, C"Blank" C*8:0~04/06~ C- C*8: SSP-JAPN-007-WS-00 REV : PAGE 2 OF 33

13 Serology Equivalent Allele Group B7, B-, B"Blank" B*07:02:0~02:02/02:04~ 02:27/02:29~02:33/02:3~ 02:47/07/09/~2/4/7~ 8:02/20~24/26/28/3/39/ 4/44~47/49N/~2/7~9/ 6~62/64/66~68:03/70~7/ 74~77/79/82/87~89/9~ 96:02/98~99/0~04/07~ 08/N/4~2/24/26~ 30/32/3N~36:02/4~ 4/0/2~64/66~7/ 78/8N/84~9/93~94/ 96~200/203~204/208/2~ 22/2~28/220~22/224~ 227/229~23N/233/237~243/ 24~246/248~ B7, B- B*07:02:03/30/63/73/09/ 33/48/20/ B7, B- B*07:02:28/0/37/6:02/ 83/2/77/83/ B7 B*07:02: B703, B7, B- B*07:03/08/6/0/ B7, B- B*07:04// B7, B-, B"Blank" B*07:0:0~0:03/0:0~ 06/80/90/0/2/37~38/ 40/76/82N/20N/20/ ~24/222 B7 B*07:0: B- B*07: B- B*07:0/79/92/9/ B- B*07: B- B*07: B- B*07: B- B*07: B- B*07:47/:0~: B- B*07: B7 B*07: B- B*07: B- B*07: B-, B8, B"Blank" B*07:202; B*8:02~04N/ B- B*07: B- B*07: B- B*07: B- B*07: B- B*07: B- B*07: B- B*07: B- B*07: B- B*07:29/ B- B*07:3/ B- B*07:32/ B- B*07:33:0~33:03/42/60/ 06/3/22/39/6 3 0 B- B*07: B- B*07:36/ B- B*07: B7, B- B*07:40/ B- B*07:48/ B- B*07: B- B*07:6:0 8 B- B*07: SSP-JAPN-007-WS-00 REV : PAGE 3 OF 33

14 Serology Equivalent Allele Group B- B*07: B- B*07: B- B*07: B- B*07: B- B*07: B- B*07: B8, B-, B"Blank" B*08:0:0~0:04/0:06~ 0:07/0:09~0:0/0:2~ 0:3/04~0/08N/0/3~4/ 8~9N/22~24/26:0/28/ 30N~3/33~3/39/4~42/44~ 48/0~//6:02~9:02/ 6~64/68~7/73~7/77/80~ 83/86N~88/90~93/9~96/98~ 00/02~06/08~3/~ 6/9~22/24/27~28/ 30/34~3/37~38/40~ 42/44~ B8, B-, B B*08:0:0/8; B*:04/ B8, B- B*08:0:08/66/94/ B8, B- B*08:0:/26:02/6: B8, B- B*08:02~03/2/78/7/ B8, B- B*08:07/ B8, B- B*08:09/84; B*: B- B*08: B- B*08:/2/40/ B- B*08: B-, B8 B*08:2:0~2:03/6/27/ 49/ B- B*08:23/ B8 B*08: B-, B8 B*08:7/38/ B- B*08:20/3:0~3: B- B*08: B-, B8 B*08:29/36/97/4/3/ 36/ B- B*08:32/33; B*3: B- B*08:43/ B- B*08:60/ B-, B"Blank" B*08:6/72N B"Blank" B*08:67N B- B*08: B- B*08:89/07; B*: B3, B-, B"Blank" B*3:0:0~0:0/03// 7/22:0~2/29/43/0/2/ 7/60~6/63N~64/73/76N~ 20 78/80 B*3:02:0~02:8/08/8/ B3, B-, B"Blank" 27/32~34/37~38/40~42/44~ 4/47/49N/4~6:02N/6~ /68~70/74~7/8~82/84 B- B*3:04/26:0~26: B-, B3 B*3:06/0/2:0/3:0~ 3:02/2// B"Blank" B*3:07N B- B*3: B- B*3:2: B- B*3: B- B*3: B- B*3:6/ SSP-JAPN-007-WS-00 REV : PAGE 4 OF 33

15 Serology Equivalent Allele Group B- B*3: B- B*3:20/ B- B*3: B- B*3: B- B*3: B- B*3: B- B*3:39 B- B*3:46/ B- B*3: B- B*3: B- B*3: B- B*3: B- B*3: B- B*3: B- B*3: B64, B"Blank", B- B*4:0:0~0:03/07N~ 08:02/0/2/4/26/32/40/ B64 B*4:0: B64 B*4:0: B64, B6, B4, B-, B"Blank" B*4:0:06~02:04/02:06~ 02:07/02:09~02:2/03~04/ 06:0~06:02/09/~8/20/ 22/24~2/29/3/36/38~39/ 4N~4/48~ B6, B- B*4:02:0/02:08/30/ B6 B*4:02: B- B*4: B- B*4:/ B- B*4: B- B*4: B- B*4:2 2 0 B- B*4:23; B*8: B- B*4: B- B*4:33 33 B- B*4:3 2 B- B*4: B- B*4:46; B*39:30/70/ B62, B"Blank", B-, B76, B B*:0:0:0~0:8/ 0:20/0:22~0:24/0:26/ 0:28~0:30/0:32~0:39/ 04:0~04:02/07:0~07:03/ 2/4/9/26N~28/32:0~3/ 38:0~38:02/4/6/60/63/ 70/7/78:0~79N/8~82/92/ 96~97/02/04~0/09~ N/3/6~8/2~26/ 29/40~42/4~47/2/ 9~60/63~67/69/72/ 74/78~79:02/8N~84/ 87/90N/92~93/20/203/ 20~207/2/27~28Q/22/ 227~228/23/234/236/244~ 24Q/247~248/27~28N/ 260~262N/264/267/269~270/ 272N/276/278~280/286~287/ 29~296/298~299/304N/309/ 36/320~32Q/326~327/33/ 333~334/340/343~344/346~ 33/3/39/ SSP-JAPN-007-WS-00 REV : PAGE OF 33

16 Serology Equivalent Allele Group B62, B-, B"Blank" B*:0:9/0/20/49N/ 246N/ B62, B- B*:0:2/7/3/ B62, B- B*:0:2/0:27/ B62, B- B*:0:3/6/84/86/28/ 37/88/224/232~233/237/ /37/322/342 B*:02:0~02:03/02:0~ B7, B-, B"Blank" 02:09/88/39/70/23~24/ 29/30~302N/39/32/328/ /34/34/37~38 B7 B*:02: B72, B70, B- B*:03:0~03:02/03:04/ 6/9/03/23/27/3~ 32//8/73/20/220/ /266/28~282 B72 B*:03: B72, B, B- B*:03:0/29/64: B62, B- B*:0:0~0:02/39:0~ 39:02//8/9/288/ /332 B62, B- B*:06/48/07/29/ B7, B-, B62, B"Blank" B*:08:0~08:02/:0~ :06//76/48/9/209N/ /284/30 B70, B- B*:09/229/ B*:0:0/0:03~0:04/ 8:0~8:02/8:04~8:06/ B7, B-, B"Blank", B70 37/90/33~34/3/6/ 76/97~98/200/226N/263/ /290/294N/306~307/32~ 33/33/337~338 B7 B*:0: B- B*: B7 B*: B B*: B- B*: B- B*: B77 B*:3:0~3: B- B*: B- B*: B-, B46, B"Blank" B*:43; B*46:0:2/04/ 6/3/4N/47 24 B- B*: B- B*: B63, B- B*:6:0~6:03/67/24/ B*:7:0:0~7:03/62/ B-, B63 68/77/96/208/26/273/ B- B*: B7, B- B*:8:03/ B- B*: B- B*: B- B*: B62 B*: B- B*:202/ B7 B*: B- B*:22; B*4:2; B*4: B- B*: B- B*: SSP-JAPN-007-WS-00 REV : PAGE 6 OF 33

17 Serology Equivalent Allele Group B- B*:23/ B- B*: B- B*: B-, B62 B*:24:0~24:02/87/ B- B*: B- B*:242/ B- B*: B- B*: B-, B62 B*:2:0~2:03/204/240/ 20/ B- B*: B- B*: B- B*: B- B*: B- B*: B- B*: B- B*: B- B*: B- B*: B- B*: B- B*: B-, B62 B*:30/8/0/ B- B*: B-, B3 B*:308; B*3:2:0~ 2:03/9/49/20/ B7 B*: B- B*: B- B*: B- B*: B- B*: B- B*:36/ B- B*: B- B*: B- B*: B- B*: B- B*: B72, B- B*:46/ B- B*:47:0~47: B- B*: B- B*:0/ B70 B*: B70, B-, B B*:2/4/24/238/292/ 34/ B- B*: B B*: B- B*: B- B*:64: B-, B"Blank" B*:66/94N/ B3 B*: B- B*: B-, B62 B*:7/ B62 B*: B- B*:74/ B- B*: B70 B*: B- B*: B- B*:8/ B- B*: B7 B*: B- B*: SSP-JAPN-007-WS-00 REV : PAGE 7 OF 33

18 Serology Equivalent Allele Group B- B*:99/ B8, B-, B"Blank", B3, B3/22 B*8:0:0:0~0:/ 0:3~0:20/0:22~07:0/ 08/0~/7N~8/23N~2/ 28/3~32/34/38~39/42~ 44:02/46~47/0~3//9~ 60/62~6/68~78/80~96/98/ 00/02~04/06/09/~ 2; B*3:24:02/29:0~ 29:02/32:0/37/8/68:0~ 68:02/7~76/98/27/36/ /3/86/200/23/2/ 286/ B8, B- B*8:0:2/07:02/ B8, B- B*8:0:2/4/ B8 B*8: B- B*8: B- B*8: B- B*8:3/20~2/40~4; B*3:99/229/232/ B- B*8: B- B*8: B- B*8: B-, B3, B"Blank" B*8:22/0; B*3:0:0:0~0:38/ 0:40~0:4/03:0~03:02/ 03:04~03:2/07/:0~ :02/:0~:02/7:0/ 20:0~2/23~24:0/30/33~ 34/36/40N~42:02/48/2~/ 7/6Q/70/74/77~78/90~94/ 0:0~0:02/03~04/ 06~08:02/0~3/6/ 9~20/22~26/28/30N~ 32/34N/37~4/43~48/ 0:0~0:02//9~ 6/6N~68/70~7/7/ 77~8/89~9/93~96/ 202/204/209/22/26N/28~ 29/22/223~224/227~228/ 237~24/243~247/249~20/ 22~23/26/263/268/272/ 27/279~282/287/289~290/ 29~ B- B*8:26/6/ B- B*8: B- B*8: B- B*8: B- B*8:3/ B-, B3 B*8:36/7~8/0; B*3:32:02/ B- B*8: B- B*8:49/ B-, B3 B*8:4; B*3:0:0~06/ 08:0~08:02//8/20/23/ ~27/29~30/32~3/37/39 B*8:6/3; B*3:43:0/ B-, B3 67/79/86/02/7~8/26; B*46:40:0~40:02 B-, B3 B*8:66/08; B*3:03:03 43 B- B*8: SSP-JAPN-007-WS-00 REV : PAGE 8 OF 33

19 Serology Equivalent Allele Group B27, B-, B"Blank" B*27:0/03~04:0/04:04~ 0:0/0:07/0:0/0:8/ 0:23/0:3~06/09~0/3/ 7/9/2/2/3/37/47/66N/ 68~69/96:02/09~/7~ 8/28/ B27 B*27:02: B27, B-, B"Blank" B*27:02:02/30/3/7/62/ 6N/77/83/9/02/26/ B27, B-, B"Blank", B47, C- B*27:04:02~04:03/0:06/ 0:08~0:09/0:~0:7/ 0:9~0:22/0:24/0:26~ 0:30//27~28/3/39/4~ 46/48/0:0~/4~6/8~ 6/64N/70~74/78~80/82/84~ 88/90:0~9/93~94N/96:0/ 97~0/03~0/07~08/ 20~2/23~24/29/32~ 33/3/37~38/40~42; B*44:64:0~64:02; B*47:0:0:0~0:02/04~ 0; B*7:3/9/30; C*6:8 B27, B- B*27:0:2/6 39 B27, B- B*27:07:0// B27, B- B*27:07:02~07:04/34/43; B*44: B2708 B*27:08 39 B- B*27: B- B*27: B27 B*27: B- B*27: B-, B44, B"Blank", B2 B*27:27; B*44:02:0:0~ 02:02/02:04~02:32/02:3~ 02:39/03:2~03:26/0:0/ 0:03~0:04//9N/22~ 23N/27:0~28:02/33~3/42/ 48~49/2N~3/8N~9:02/ 63/66~68/70~74/78/80/ 84:02/86~87/89/9/93/97~ 98/0~02/04/2~3/ 6~9/2/26:0~ 26:02/33/36~37/39/ 42/48~49N/~2/62/ 68~7N/73/76~77/79/ 8/87/9/9N~96/20/ 206/208/2/24/26~ B- B*27:30; B*40: B27 B*27: B- B*27: B- B*27: B27, B- B*27:20/ B- B*27: B- B*27:26/40/42/44/89 B27 B*27: B- B*27:33 49 B-, B44 B*27:36; B*44: B27 B*27: B-, B7 B*27:4/36; B*7:0:0/ 2~26/43/67; B*8:36/ B-, B37 B*27:2; B*37:0:09/ SSP-JAPN-007-WS-00 REV : PAGE 9 OF 33

20 Serology Equivalent Allele Group B*27:63/39; B*44:82; B-, B7 B*7:0:02/03:0~03:02/ /3~32/39/46/66/70 B- B*27: B- B*27: B-, B44 B*27:76; B*44:03:7/37:0~ 37:02/47/6/4/20/93/ /203; B*7:4 B- B*27:8 0 4 B- B*27: B3, B-, B"Blank" B*3:0:39/7:02/2/ 73N/248/ B*3:02:0~02:02/02:04~ 02:07/04:0~04:03/06/ 08:0/08:03~08:04/08:06~ 09:03/:03/6:0~6:02/ B3, B-, B"Blank" 64:0~64:02/83/88/9/00/ 0/2/29N/33/42/6/ /72/74/76/82~84/ 87/92/20~206/2/24/ 220/22/230/28/262/264/ 28/29 B3 B*3:02: B3, B- B*3:0:0~0:03/72/89/ B3 B*3:08:02/08:0 4 B3, B- B*3:0/3/6/28/ B- B*3: B3, B- B*3:4:0~4:02/62/63/ B- B*3:4; B*40: B- B*3: B- B*3:64/ B-, B3 B*3:8/8/ B- B*3: B- B*3:88/ B3, B- B*3:9/203/20/27/ B- B*3: B- B*3: B- B*3: B- B*3: B- B*3:222; B*8:4 43 B- B*3: B- B*3:234/ B3 B*3: B- B*3: B- B*3:27/ B- B*3: B3, B- B*3:27/ B- B*3: B- B*3: B- B*3: B- B*3:3/ B-, B3 B*3:3/236/ B- B*3:38//69/ B- B*3:39/ B3 B*3: B- B*3: B3 B*3: B- B*3: B- B*3: SSP-JAPN-007-WS-00 REV : PAGE 20 OF 33

21 Serology Equivalent Allele Group B-, B3 B*3:0/84/97/23/267/ B-, B3 B*3:/ B3 B*3: B- B*3:63/ B- B*3: B- B*3: B- B*3: B-, B3 B*3:80/ B- B*3:82/ B- B*3:96/ B37, B-, B"Blank" B*37:0:0~0:0/0:07~ 0:08/0:0~03N/2~3/~ 8/20~2/23/2~27/29~33N/ /38/4~47/49/~ B37, B- B*37:0:06/06:0~06: B37 B*37:04:0~04: B- B*37: B- B*37: B37 B*37: B37 B*37: B37 B*37: B- B*37:/ B- B*37: B- B*37:9/ B- B*37: B- B*37: B- B*37: B- B*37:3/ B- B*37:39/ B- B*37: B38, B-, B6, B"Blank" B*38:0:0~02:07/08~09/ ~/8/20~24/27/3/34N~ 3/38~44/47~49//3/Q~ B6 B*38: B- B*38: B38 B*38: B- B*38:06~ B- B*38: B- B*38:6~7/28/ B- B*38: B- B*38: B- B*38: B- B*38: B- B*38:30/36~37/4/ B- B*38: B- B*38: B- B*38: B- B*38: B390, B39"Low", B39, B-, B"Blank" B*39:0:0:0~0:0/ 0:07~0:3/0:6~0:22/ 0:0~0:02/09:0~09:03/ /2N~28/3/38Q/40:0N~ 42/44~47//3~4/6~7/ 9~6/6~68/7/73/7/77~ 8/84~87N/92~9N/97N~98/ B390, B- B*39:0:06/2/ B390 B*39:0: SSP-JAPN-007-WS-00 REV : PAGE 2 OF 33

22 Serology Equivalent Allele Group B390, B- B*39:0:/00/ B3902, B39, B- B*39:02:0~02:02/08/ 3:0/23/ B39, B- B*39:03/24:0/37/ B39 B*39: B39, B- B*39:06:0~06:0/62/64/ B-, B39 B*39:07/// B39, B- B*39:0:0~0:02/6~7/ 20/39:0~39:02/8/72/88~ /96/99 B- B*39: B39 B*39: B39 B*39:3: B- B*39: B- B*39:8/ B39 B*39:9: B39 B*39:9: B- B*39: B39 B*39:24: B- B*39: B- B*39: B- B*39: B39 B*39: B- B*39: B- B*39: B- B*39: B- B*39: B39 B*39: B- B*39: B- B*39: B- B*39: B60, B-, B"Blank" B*40:0:0~0:04/0:06/ 0:08~0:2/0:4~0:9/ 0:2~0:30/0:32~0:39/ 0:4~0:43/07/22N/2/30/ 33~34/36/38/42~43/2/4~ /60~62/6~67/69/72:0~ 73/77/79/8/84/87:0~88/ 00~02/06/08/2/6/ 8N/23~26/28/32/34/ 38~4/46~47/0~6/ 66/68/7~72/7/79/ 86~87/9~92/94~97/ 99/204/207/23/2~26N/ 22~222/227~228/233~24/ 24/247/249~20/22~23/ 27~264/272~273/277~280/ 282/286N/288/299~ B60, B-, B"Blank" B*40:0:0/70/242/26N 4 47 B60, B-, B4 B*40:0:07/0:20/30:0~ 30:02/78/28; B*4:0:0~0:04/03:0~ 03:02/06~07/09/2/4/6~ /20/2/28~30/32/34~3/ 37; B*4:08 B60, B- B*40:0:3/0:40/0:0~ 0:02/49/82/208/ B60, B- B*40:0:3/93/22/27~ 28/223/ SSP-JAPN-007-WS-00 REV : PAGE 22 OF 33

23 Serology Equivalent Allele Group B6, B-, B"Blank" B*40:02:0~02:2/02:23~ 03/08~09/8/24/27:0~ 27:02/29/3:0~3:02/40/ 0/6~7/78/82/8/89~9/ 94/97/04~0/07// /9/22/33Q/42N~ 4/69/73/76/80~8/ 89/200/202~203/20~206/ 2/24/220/224/226/229/ 232/246/248/24~2/266~ 267/27/274/276/283~284/ 287/289~29N/293/296~297/ 302~ B6 B*40:02: B6, B-, B40 B*40:04/64/68/ B400, B2 B*40:0/ B6, B-, B"Blank" B*40:06:0:0~06:08/ 06:0~06:2/44/70:0~ 70:02/03/3/62/6/ /77/90/230/244/26N/ 268/270/27/294/307 B6, B- B*40:06:09/86/ B- B*40: B6, B- B*40::0~:02/20/99/ 22/ B- B*40: B- B*40: B- B*40: B- B*40:27/ B- B*40:3/9/ B- B*40: B-, B60 B*40:4:0~4:03/32/ 4:0~4:02/2/36/ ; B*4:08 B- B*40: B-, B6 B*40:~6/23/ B- B*40:7/ B- B*40: B- B*40: B- B*40:83/ B- B*40: B- B*40: B- B*40: B- B*40: B- B*40: B- B*40: B- B*40: B- B*40: B- B*40: B60, B- B*40:3/ B- B*40: B4 B*40: B- B*40: B- B*40: B-, B40 B*40:47/ B60 B*40: B- B*40: B6 B*40: B- B*40:8/64/ B- B*40:9/60:0~60: SSP-JAPN-007-WS-00 REV : PAGE 23 OF 33

24 Serology Equivalent Allele Group B- B*40: B- B*40: B- B*40:74/ B- B*40: B- B*40:76/ B- B*40:83/ B40 B*40: B- B*40: B- B*40:9/48/ B- B*40: B- B*40: B4, B- B*4:02:0/02:03~02:06/ 0~/3//23~24/27/3/ /38~39 B4 B*4:02: B- B*4:04/ B- B*4:0/ B- B*4: B- B*4: B-, B47 B*4:33; B*47:02 48 B42, B- B*42:0:0~02:0:02/06/ 08/0/4~/7~8/ B- B*42: B- B*42:0:0~0: B- B*42: B- B*42:09/ B- B*42: B- B*42: B- B*42: B- B*42: B- B*42: B44, B-, B47, B"Blank" B*44:02:03/03:28~04/ 0:02/4/6/2/6N/62/76/ /24/32/63/90 B*44:02:33~02:34/20/ B44, B-, B7 4:0~4:02/99~00/38Q; 2 4 B*7:04~0 B44, B-, B"Blank" B*44:03:0~03:/03:8~ 03:20/03:22~03:24/03:27/ 07/3/26/29~30/32/36/38~ 39/6N/69/8/92/94/96/ 0/08N~0//22/2/ 28/4/43~44/47/3~ /7/9/6/64~6/ 67/7/78/80/82~83/ 86/89/92/98N~99/202/ 204/207/209/ B44, B- B*44:03:6/ B44, B- B*44:03:2/4/77/79:0~ 79:02/60Q/74/2/223; B*7:07 B44 B*44:06/ B44 B*44: B4 B*44: B44 B*44: B- B*44: B- B*44:06/ B- B*44:27/4/72/ B- B*44: B- B*44: B- B*44: SSP-JAPN-007-WS-00 REV : PAGE 24 OF 33

25 Serology Equivalent Allele Group B- B*44:3/ B- B*44: B- B*44: B2 B*44: B- B*44:0 8 4 B- B*44: B- B*44: B-, B44 B*44:7//23; B*7: B- B*44:8; B*49: B- B*44: B- B*44: B- B*44:94/20:0~20: B- B*44: B- B*44: B- B*44: B- B*44:2/ B-, B44 B*44:40/ B-, B44 B*44:43:0~43:02/ B- B*44: B- B*44:46/ B- B*44:0:0~0: B44 B*44: B44 B*44: B- B*44: B- B*44: B- B*44: B- B*44: B- B*44:84: B- B*44: B- B*44: B4, B- B*4:0:0/03~07/~ B4 B*4:0:08 2 B- B*4: B- B*4: B-, B0 B*4:4~; B*0:0:03/2/ B- B*4: B46, B"Blank", B- B*46:0:0~0:/0:3~ 02/0/07N/09~0/2/4~ N/7/20/22~24/26~28/30/ 24 32/34~39/42/44~46/49~8/ 60/63 B46 B*46:03 66 B- B*46:06 47 B- B*46:08/3:0~3:03/ B- B*46: 3 B- B*46: B- B*46: B- B*46:2:0~2:02/2/33 43 B- B*46: B- B*46:48 24 B- B*46:9/62/64 B- B*46: B47 B*47: B48, B- B*48:0:0~0:06/07/09/ /4/9/27/29~32/34~ B48, B- B*48:02:0/ B48 B*48:02: B48 B*48:02: B48, B- B*48:03:0~03:02/2/23/ SSP-JAPN-007-WS-00 REV : PAGE 2 OF 33

26 Serology Equivalent Allele Group B48, B- B*48:04:0~04:02/3/ B48 B*48: B- B*48:06/ B- B*48: B48, B- B*48:0/ B- B*48: B48/40V B*48: B- B*48: B- B*48:20/ B- B*48: B- B*48:28/ B- B*48: B49, B-, B"Blank" B*49:0:0/0:03~0:08/ 06/2~7/9N~20/22~23/27~ /32~3/37~39 B49 B*49:0: B49 B*49: B- B*49: B- B*49:04:0~04: B49, B- B*49:0/08/8/ B47 B*49: B- B*49: B- B*49:0/ B- B*49: B- B*49: B- B*49: B- B*49: B0, B4, B- B*0:0:0~0:02/0:04~ 04/08/0~/~6/8~9/ ~37/40~42 B- B*0:0/ B- B*0:06/3/ B- B*0:09/4/33/ B- B*0: B- B*0: B- B*0: B- B*0: B- B*0: B, B03, B-, B"Blank" B*:0:0:0~0:0/ 0:2~0:3/0:~0:6/ 0:8/0:20~0:30/0:32~ 0:46/0:49/0:~0:3/ 03/07:0~07:02/N~2/4/ 8/24:0~28/30/32~33/38/ 4N/43/48~3/8/60/66/68~ 7/74~77/79~80/83~84/86/ 88~89/9~96/98N~00/02/ 0/07/09/~4/7/ 9~2/23~34/36~38/ 40/42/4/47/49N~/ 4~/6~70/73Q~74/ 76~79/82~8/87~ B, B"Blank", B- B*:0:/0:7/8N/ B, B"Blank", B- B*:0:4/67/0N/9/ B, B- B, B02, B- B*:0:9/0:47/09:0~ 09:02/9/72~73/87/9/94/ /22/8 B*:0:3/0:0/02:03/ 7/40/08/ SSP-JAPN-007-WS-00 REV : PAGE 26 OF 33

27 Serology Equivalent Allele Group B, B- B*:0:48/04/06:0~ 06:02/3/46/63~64/2/ B02, B- B*:02:0~02:02/02:04~ 02:0/23/7/ B, B- B*:0/08:0~08:02/20/ B- B*:0/ B- B*: B- B*: B- B*:3:0~3: B- B*: B- B*: B- B*: B- B*: 3 4 B- B*: B- B*: B, B- B*:6/ B- B*: B- B*:2/ B- B*: B-, B B*:29//6:0~6:02/ 6/6/8:0~8: B B*: B- B*: B- B*:36/ B- B*:37/4/ B- B*: B- B*: B"Blank" B*:44N B- B*: B- B*:6:0~6: B- B*:7/ B- B*: B- B*:62/ B- B*:78:0~78: B- B*: B- B*: B- B*: B- B*:92:0~92: B- B*: B2, B-, B"Blank" B*2:0:0:0~0:0/ 0:2~0:8/0:20/0:22~ 0:23/0:27~0:28/0~07/ /3//7/22~23/28~30/ 33/36/38/40~42/4~0 B2, B- B*2:0:/0:0~0:03/ B2, B- B*2:0:9/04/34~ B2, B- B*2:0:2/0:24/2/24/ 3:0~3:02/ B- B*2:02:0~02: B- B*2: B2 B*2: B- B*2: B2 B*2: B- B*2: B- B*2: B- B*2:8/ B- B*2: B- B*2: B- B*2: B- B*2: SSP-JAPN-007-WS-00 REV : PAGE 27 OF 33

28 Serology Equivalent Allele Group B- B*2: B- B*2: B- B*2: B3 B*3: B- B*3:09/2~3/ B- B*3:0 43 B3, B- B*3:/ B- B*3: B- B*3:6/9/24 4 B3, B- B*3:7:0~7:02/ B- B*3: B- B*3: B- B*3: B4, B-, B"Blank" B*4:0:0~0:06/04/07~ 08N/0~/3/~9/22~2/ ~32/34 B4 B*4:0: B4, B"Blank" B*4:02/0N 6 38 B- B*4: B- B*4: B- B*4: B- B*4: B- B*4: B- B*4: B- B*4: B- B*4: B- B*4: B, B22, B-, B"Blank" B*:0:0~0:2/0:4/ 03/0//7/2/2/28~29/ 3/33/36/38/40/44~4/2~ /9~60/64/66/74~7 B, B- B*:0:3/ B, B4, B22, B- B*:02:0:0~02:09/07/ 2~3/6/9~20/26/32/34/ 37/39/4~43/46~48/0/7~ /6~63/6/67/69~7; B*6:23 B6 B*: B22, B- B*:09/ B B*: B- B*: B- B*:4; B*6: B, B- B*:22; B*6: B- B*:23/ B- B*: B- B*: B- B*: B- B*: B6, B-, B"Blank" B*6:0:0:0~0:04/ 0:06~02/08/3~4/7/ 20:0~20:02/24/26/28N~30/ /38N/40~4/47~49 B6, B, B"Blank", B- B*6:0:0/0/2/9N/22 37 B22 B*6: B6, B- B*6:04/ B6 B*6:0:0~0: B78 B*6:06; B*78:0:0~02: B6, B- B*6:07/ B-, B6 B*6:09//8/ B6 B*6: 6 37 SSP-JAPN-007-WS-00 REV : PAGE 28 OF 33

29 Serology Equivalent Allele Group B6 B*6: B- B*6:2/ B- B*6: B- B*6: B- B*6:3 3 B- B*6: B- B*6:42/ B- B*6: B- B*6: B7, B-, B"Blank" B*7:0:0/0:03~0:07/ 0:09/0:~0:22/06// 4:0~6/8/20~23/27/29/ 33/3~38/40/44~4/47~0/ ~6/8~62/64~6/68~69/ 7~79N B7, B- B*7:0:08/08/ B7, B"Blank", B- B*7:02:0~02:02/28N/ B- B*7: B- B*7: B- B*7: B- B*7: B- B*7: B- B*7: B8, B-, B"Blank" B*8:0:0:0~0:4/ 0:6~0:7/0:9~07/09~ 7N/9/2/23~26/29~3/37~ /43/4:0~4:02/47~3/ ~60/62~63/66~72N B8, B- B*8:0:/0:8/22/ 28:0~28:02/46/6/ B7 B*8:08:0~08: B- B*8: B8 B*8: B- B*8: B- B*8: B- B*8: B9, B- B*9:0:0:0~03/0~ B- B*9: B- B*9: B- B*9: B67, B- B*67:0:0~0:03/03~ B- B*67: B73, B- B*73:0~ B- B*78: B- B*78: B- B*78: B- B*78: B- B*78: B- B*78: B8 B*8: B- B*8: B- B*8: B82, B- B*82:0~ B- B*83: SSP-JAPN-007-WS-00 REV : PAGE 29 OF 33

30 DR Locus 9 0 H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A 2 Serology Equivalent DR Locus Allele Group DR, DR-, DR"Blank" DRB*0:0:0~0:4/ 0:6~02:/04~0/07/ :0~:02/3~4/7~2/ 24:0~28/30~32/34~38/40N~ 4/43~0/2N~4/6~60/ 62N~67/69~7 DR- DRB*0: DR7, DR3, DR-, DR"Blank" DR7, DR8, DR3, DR-, DR"Blank", DR3, DR4 DRB*03:0:0:0~0:0/ 0:07~0:08/0:0~0:/ 0:3~0:20/0:22~0:24/ 04:0/0:0~06/09~:0/ 3:0~6/8~20/22~23/2~ 26/28/30~34/36~37/39/43~ 4/47~48/0~2/~8/60~ 63/66/68N~73/77~78/80~84/ 89/9/93~9/99~00:02/ 04/06~08/2/4/6~ 7/2 DRB*03:0:2/0:2/ 0:2~03/04:02/07/2/2/ 24/27/29/3/38/3~4/67N/ 74/79/8/88/90/96~98/0~ 03/09~0/3//20; DRB*3:0:07/02:0/20/ 29/43/4/6/60/63/74~7/ 78/88/0~/4/2/ 33~34/40/80/84; DRB*4:0:03/32:0~ 32:03/34/38:0~38:02/8/ 6/69/74/8/87/9~92N/94/ 97~98/00/04//2/ 23/27:0~27:02/9~ 62; DRB3*0: DR-, DR DRB*03:08/6; DRB*:3:0~3:02/ DRB*03:7/40~4:02/0; DR-, DR3 DRB*3:24~2/44/86/49; DRB*4:42/6 DR-, DR2 DRB*03:42/87; DRB3*0:07/ DR- DRB*03: DR- DRB*03:7/ DR- DRB*03:76; DRB*4:82/9/ DR- DRB*03:86/ 73 DR- DRB*03: DR4, DR-, DR"Blank" DRB*04:0:0~0:02/ 0:04~0:09/0:~0:3/ 0:/02:0~03:0/03:03/ 03:0~04:0/04:03~04:0/ 04:08~04:09/07:0~08:0/ 08:04/3~4/8/22~23/2/ 27/3~39/42~44/47/0~ 6:0/8~60/64/66/70~ 72:02/74~76/79/88/92~ 98:02/00~0/0:02/09/ ~2//7~24/27~ 30/32~3/39~43/48~ /3/~60/63/6~ 68/7/74~7/77/79/ 8~83/8/88~90/92~ SSP-JAPN-007-WS-00 REV : PAGE 30 OF 33

31 DR Locus H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A Serology Equivalent DR Locus Allele Group DR4, DR-, DR"Blank" DR- DR7, DR-, DR"Blank" DR8, DR-, DR"Blank" DR8, DR- DRB*04:0:03/0:0/ 0:4/0:6/03:02/03:04/ 04:02/04:06~04:07/0:0~ 0:6/0:8~06:0/08:02~ 08:03/09~2/~7:02/9~ 2/24/26/28~30/40~4/4~ 46/48~49/6:02~7/6~62/ 6/67~69/73/77~78/80~87/ 89~9/99/02~0:0/06~ 08/3~4/6/2~26/ 3:0~3:02/36~38/ 44~47/2/4/62/64/ 69~70/73/76/78N/80/ 84/86N~87/9 DRB*04:63/0/6; DRB*08:7 DRB*07:0:0:0~0N/2~ 24/27~60 DRB*08:0:0~0:0/ 03:02~03:0/04:06/0~08/ 0~2/4~9/22~23/26~27/ 29/30:02/33~34/36:0~37/ 39~40/42~43/46~6/8/60N~ 62/64~66/68~74/76; DRB*3:03/60 DRB*08:02:0~02:04/ 04:0~04:0/04:07/3/24/ 28/30:0/30:03/44~4/9/ DR8, DR- DRB*08:09/2/3; DRB*4:/2/26: DRB*08:20; DRB*3:07:0/ DR-, DR3 :0/4:0/4:03/22~ :02/37/47/70/82/0 DR, DR- DRB*08:3/4; DRB*3:9; DRB*4:7 79 DR- DRB*08:32; DRB*2:09/46/ DR- DRB*08: DR- DRB*08:63/7; DRB*:67; DRB*3: DR9, DR- DRB*09:0:02~06/08~09/ ~4/6/8~22/24~26 84 DR- DRB*09: DR0, DR- DRB*0:0:0~ 8 DR, DR-, DR"Blank" DRB*:0:0~0:7/ 0:20~02:04/04:0~04:2/ 06:0~06:03/09/4:0~6/ 8~2/23:0~2/27:0~ 29:0/32/37:0~37:02/39/ 43~/4:0~4:02/6/ 8:0~8:02/60~62:02/66/ 69~7/77~78/8~82/84:0~ 84:03/86/88/90~92/94~9/ 97~0/04/06/08~3/ /7~9/2/23~24/ 26~29/32~34/37/40~ 4/44~47:02/0/2/ 4~8/60/62~67/69N/ 7~72/74/78/80~8/ 83~ DRB*:0:8~0:9/ 03:0~03:02/0/07~08:03/ :0~:03/26/30/34/36/ DR, DR- 40~42/3//7/63:0~64/ 68/76/79/8/89/93/03:0~ 7 03:02/0/07/22/2/ 3/36/38~39/43// 3/9/6/68/73/76 DRB*:0:0~0:02/ DR, DR- 2:0~2:02/80/83/87/4/ /42/49/70/79/82 DR- DRB*:02:0~02:02/ DR- DRB*: DR- DRB*:3/33/3/38/ 6:0~6:02/96/6/20/ 48; DRB*3:22/6/ 77 7:0/97 DR, DR4, DR- DRB*:2; DRB*4:/ DR2, DR-, DR"Blank" DRB*2:0:0~03:03/0~ 08/0~3/~37/39/4~4/ 76 47/0~ DR- DRB*2:04/ SSP-JAPN-007-WS-00 REV : PAGE 3 OF 33

32 DR Locus 9 0 H G F E D C B A H G F E D C B A H G F E D C B A H G F E D C B A 2 Serology Equivalent DR Locus Allele Group DR3, DR-, DR"Blank", DR4 DR3, DR-, DR6 DR-, DR4, DR"Blank", DR6 DRB*3:0:0~0:06/ 0:08~02:09/02:~06/ 07:02/09~0/:02~3/ 4:02/~6/2:0~2:02/ 26:0~26:02/28/30~36/38~ 40/42/4~46/48~3//8~ 9/6:0~62/6~66:02/68~ 69/73/77/79~8/84~8/87/ 89~02/04~06/08~09/ 2~3N//7~8/20/ 23~28/30~32/36~39/ 4~43/4/47~48/~ /7/9/6~64/66~ 70/7:02~74/77/79/ 8/8N~92/94/98~204; DRB*4:22/2/37/3/0/ 28 DRB*3:08/9/7/64/72/ 83/07/3/82; DRB*4:6 DRB*3:9/78/93/96; DRB*4:0:0~0:02/ 0:04~02:02/0:0~09/3~ 4/7~2/23:0/23:03~ 23:04/26/29~30/33/3~36/ 39/4/43~4/47~49// 4:0~6/9~60/62/64/70/ 7/80/83~84/86/88/90/96/ 99/03/06/08~0/2~ 4/7~9/22/24~2/ 29/3/33~34/36~37N/ 39~40/42/44/46~47/ 49~/3~/7~8/ DR- DRB*3:29/ DR- DRB*3: DR-, DR3 DRB*3:7/ DR-, DR3 DRB*3:8/46/6/ DR3, DR- DRB*3:27/ DR- DRB*3: DR- DRB*3: DR403, DR-, DR4 DRB*4:03:0~03:02/ 2:0~2:02/40/8/89// DRB*4:04:0~04:02/0/ 23:02/28/46/6/68:0~ DR404, DR4, DR-, 68:02/7~73/0/20/ DR"Blank" 26:02/30/38/43/4/ 8 2N DR- DRB*4: DR-, DR2, DR"Blank" DRB*4:4; DRB3*0:0:02:0~06/08~ 3/6; DRB3*02:0~7/9~ 87 2/28~29N; DRB3*03:0:0~ 03 DR- DRB*4: DR- DRB*4: DR4, DR- DRB*4:27/63/67/ DR- DRB*4: DRB*:0:0:0~06:03/ 08~0/2~6/9~20/22~24/ DR, DR2, DR-, DR"Blank" 26/29~33/3~3/~6/67~ 68/7~83/8~87/89~9/97~ 7 99/0~02/04~2/4/ 6/8~9/23~24 DR, DR-, DR"Blank" DRB*:07:0~07:03// 88/96/N 7 72 DR-, DR6, DR2, DR"Blank" DRB*:34; DRB*6:0:0~ 08//3N~32/34~3 72 DR- DRB3*02: DR3, DR-, DR3"Blank" DRB4*0:0:0:0~07/09 88 DR, DR-, DR"Blank" DRB*0:0:0~; DRB*02:02~06 86 SSP-JAPN-007-WS-00 REV : PAGE 32 OF 33