RIVA 2014 COMPLETE YOUR AGILENT TOUR. Better Connections with Agilent. Ken Lynam CSD R&D/Applications Chemist, Wilmington, DE USA.

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1 RIVA 2014 COMPLETE YOUR AGILENT TOUR Better Connections with Agilent Ken Lynam CSD R&D/Applications Chemist, Wilmington, DE USA 1

2 GC column installation is a challenge A routine, basic procedure, but not easy to do Plus a minimum of 2 chances to get it wrong! Very small parts Wrenches in cramped, dark space Even when done correctly, fittings are known to be prone to leaks 2

3 How do you make leak free column connections? Start with the right tools and supplies Assemble the parts Column Nuts Material : stainless but need brass for MS interface Finger tight available for graphite ferrules Choice of right ferrules Make a good clean cut every time After ferrule is installed Fused silica tubing cutters : ceramic Magnifier to inspect the cut 3

4 Which Capillary Ferrules? polyimide polyimide/graphite graphite flexible metal Composition Re-use Max T Use Limitation Polyimide (Vespel) yes 280 Easy seal Shrink after heating causing leaks after thermal cycle; isothermal only Graphite yes 450 Not MS or ECD Contamination, leakages not for oxygen sensitive detectors Polyimide/graphite (85% / 15%) limited 350 MS Still shrink after thermal cycles creating leaks; need to retighten regularly Flexible metal no 450 CFT May not seal well with damaged rough surfaces Short ferrules for inlet and detector configurations on Agilent GC s Long ferrules for MS transfer lines and MS interface nut 4

5 Graphite / polyimide capillary ferrules leak after normal temperature program runs Studies show the leaking continues with use of the ferrules Not just the first one or two runs Frequent re-tightening of the fitting with graphite/polyimide ferrules is needed to maintain a leak-free seal and system performance and productivity 5

6 Agilent Self Tightening Column Nuts Designed for use with short graphite/polyimide blend ferrules both at the inlet and the MS interface so only one type of ferrule needed for both ends of the column! For inlet or detector For mass spec transfer line Short ferrule exposes more thread of the fitting for better sealing 6

7 Benefit of Self-Tightening Column nuts Take you from this.. to this! Without retightening, the baseline remains flat after 400 runs with no indication of leaks when using the Self Tightening column nuts 7

8 Better Connections 1: Glass connectors UI Chemistries applied to press fit connectors Improved inertness performance Best in class inertness Easier to use than competitors because you can see it work! 8

9 Comparison UI pressfit to presstight Siltek deactivated pa XOffset : 0.2 YOffset : Presstight, Siltek deactivated #20480 GC28B_CONNECTOR-005_VIM2_ _CP4787_lot723838_2_1_1.DATA GC28B_CONNECTOR-007_VIM2_ _UI_pressfit_RG_1_1.DATA UI pressfit Excellent inertness, but Siltek deactivated connector not transparant Testing 86 hrs 325 C: PASSED RT [min]

10 Better Connections 2: CFT is best in class Ultimetal Plus deactivation for superior inertness Easy to assemble They don t leak! New pricing Kitted for easy ordering The un-purged splitter is so much better than a glass Y splitter because it was simple to put together. The new ferrules really made it easy. Since we installed it there have been no leaks and the performance is excellent. These results will be in my thesis Forensics Toxicology Graduate Student Pennsylvania State university 10

11 Ultimetal Plus Tubing and Fittings 0.53 and 0.25 mm ID guards and transfer lines Metal fittings (unions, tee s and nuts) Steel tubing (1/16, 1/8, ¼ ) Ultimetal Plus fused silica guard columns Superior performance for configured systems in HPI, environmental and other application spaces. 11

12 Guards:Tandem test 2 m 0.53mm ID pieces using a VIM2 mix pa XOffset : 0 YOffset : picoline Avg corr. A s 6.6 Avg. Abs. recovery 103% GC38F_UIUM-036_VIM2_CP _ _end_2m_10_1.DATA GC38F_UIUM-036_VIM2_CP _MXT _2m_11_1.DATA CF 4.7 ml/min H 2 oven 60 C MXT Biodiesel TG Guard 4.85 VIM2 (split 1:75) # Compound ng 1 Methane 2 Propionic acid 1 3 iso-butyric acid 1 4 n-butyric acid 1 5 Octene Octane Nitrobutane Picoline 2 9 Trimethyl Phosphate ,2-Pentanediol 2 11 Propylbenzene Heptanol Octanone 1 14 Decane picoline Avg corr. A s 2.3 Avg. Abs. recovery 103% Agilent UltiMetal Plus Guard Conclusion: UltiMetal Plus Guard gives equal or better inertness compared to MTX Biodiesel T G. Great results for inertness RT [min]

13 Testing the outside of a metal capillary for 24 hrs at 450 C: Metal outside of the column in flow path UltiMetal on the outside for improved inertness CPM union, inert Fleximetal ferrule INLET Bare Steel Metal outside of the column in flow path Invention disclosure filed. 13

14 Making Better GC Connections Select supplies appropriate for your instrument and application Follow recommended assembly process Maximize productivity by using innovative tools and supplies Column Installation Pre-swaging tools Self Tightening column nuts Ultra Inert Press Fit connectors UltiMetal Plus Flexible metal ferrules UltiMetal Plus tubing and fittings 14

15 RIVA 2014 COMPLETE YOUR AGILENT TOUR It s a Great Story! Thanks to great innovation and product development What started with the Inert Flowpath program last year is now expanding to include all of the flow components in the GC. This means challenging applications are now EASIER and FASTER to implement, delivering superior performance that translates to INCREASED UPTIME and FASTER LABORATORY OPERATIONS. 15

16 NOW IT S EASIER THAN EVER TO GET RELIABLE GC RESULTS THROUGH BETTER GC CONNECTIONS FROM AGILENT Order the poster View the video 16

17 Acknowledgements Agilent colleagues Lindy Miller Yun Zou Gary Lee Paul Trip Roger Firor You for your kind attention 17

18 Questions? 18