SiliCycle MiniBlock XT

Transcription

1 SiliCycle MiniBlock XT Configuration Guide

2 Table of contents Table of contents Overview XT-S Basic & XT-S Plus XT-S: Affordable Reaction Block for Synthesis and Screening XT-S Plus: Affordable Heating and Cooling with Recirculator XT Set: A Complete Reactor with Hotplate Stirrer XT packages XT Package: Two Complete Reactors with One Hotplate Stirrer Individual items XT Reactor Components XT Reactor 6, 2, 24 or 48 -positions XT Reactor Frames XT-Plus Reactor XT-Plus Reactors: 6, 2, 24 or 48 - positions Individual XT-Plus Reactor Frames XT Accessories Vessel Racks Inert Manifolds Inerting / Purging Manifold (48-positions) Purging / Evaporating (6, 2 and 24-positions) Manifold Upgrade Inerting/Purging to Purging/Evaporating Top Plate Septa & Gaskets for Inerting / Purging and Purging/Evaporating Manifolds Inner / Piercing Septa Natural Rubber Sealing Gaskets Increased Chemical Resistance Septa & Gaskets (No Vacuum) High Temperature Resistant Septa & Gaskets Septa for Top Plate Reflux Layer XT consumables Reaction Vessels Magnetic Stir Bars Heat transfer and mixing IKA Hotplate / Stirrer Components XT Low Temperature Bath Insulation Wrap Synthetic Chemists - Your Choice for Synthesis Procurement info@silicycle.com SiliCycle MiniBlock XT Configuration Guide

3 Overview System concept The XT product line is a multifunctional platform designed for: Parallel solution-phase synthesis Four reaction volumes and vessel formats to suit a variety of needs Interchange of components with SiliCycle MiniBlock solid-phase systems The XT is an easy-to-operate system which requires minimal hood space. All racks are in a microtiter plate format, providing compatibility with dry down devices and flexibility for use with automation. Chemistry capabilities Excellent temperature control and refluxing capability Reactions performed under inert or non-inert atmosphere Robust mixing of difficult solutions - magnetic stirring or orbital shaking Easy setup and cleanup Automation options XT reaction vessel racks are readily used with many common evaporators and liquid handlers. Further supporting automation is also available from SiliCycle addressing the following processes: Reagent preparation Reagent mapping Work-up / purification Weighing for yield determination Compound dissolution, screening plate preparation and compound archiving Color Guide Parts are color-coded depending on the number of positions. Blue Red Green 48 positions 48 positions 24 positions Silver Gold 2 positions 6 positions Pictures are for indicative purposes only. Color and number of positions vary depending on the configuration. 3

4 XT-S Basic & XT-S Plus XT-S: Affordable Reaction Block for Synthesis and Screening Complete synthesis system for 6, 2, 24, or 48 parallel solution-phase reactions Temperature range of -70 C* to 60 C Fully upgradable for reflux and inerting capability Consumables are included in the price Set Contents: Reactor Frame Vessel Rack Vessel Rack Removal Tool Top Plate Multi-Layer Septa, Pre-scored for Top Plate Please Choose One of the Following XT-S Reaction Blocks: Reaction vessels Magnetic stir bars Volume Shape XT-S, 6-positions 24 0 ml XT-S, 2-positions 00 ml XT-S, 24-positions 00 8 ml XT-S, 48-positions 00. ml 0 Egg *Requires XT Low Temperature Bath (374280) Magnetic Stir Bar Shape XT-S Plus: Affordable Heating and Cooling with Recirculator Complete synthesis system for 6, 2, 24, or 48 parallel solution-phase reactions Frame allows heating & cooling in a temperature range of -70 C to 60 C* Fully upgradable for reflux and inerting capability Consumables are included in the price Set Contents: XT-Plus Reactor Frame Vessel Rack Vessel Rack Removal Tool Top Plate Multi-Layer Septa, pre-scored for Top Plate Please Choose One of the Following XT-S Plus Reaction Blocks: Reaction vessels Magnetic stir bars Volume XT-S Plus, 6-positions 24 0 ml 8 Shape XT-S Plus, 2-positions 00 ml XT-S Plus, 24-positions 00 8 ml XT-S Plus, 48-positions 00. ml 0 Egg * Temperature range dependent on recirculator. Recirculator not included 4 info@silicycle.com SiliCycle MiniBlock XT Configuration Guide

5 XT Set: A Complete Reactor with Hotplate Stirrer Complete synthesis system for 6, 2, 24 or 48 parallel solution-phase reactions Compact unit enables reflux or controlled temperature synthesis (temperature range: -70 C* to 60 C) Components can be converted to 6, 2, 24 or 48 vessels Consumables are included in the price Package Contents: Reactor Frame Vessel Rack Refluxing Layer Inerting / Purging Manifold Vessel Rack Removal Tool Sealing Gaskets Inner / Piercing Septa Top Plate Multi-Layer Septa, Pre-scored for Top Plate Hotplate-Stirrer system see page 3 for details. IKA Hotplate Stirrer, V / 60Hz or 230V / 0Hz IKA Feedback Control Kit Heat Dispersion Adapter for IKA Please Choose One of the Following XT Sets: V 230V Reaction vessels Magnetic stir bars Volume Shape XT Set, 6-positions 24 0 ml XT Set, 2-positions 00 ml XT Set, 24-positions 00 8 ml XT Set, 48-positions 00. ml 0 Egg * Requires XT Low Temperature Bath (374280)

6 XT Packages XT Package: Two Complete Reactors with One Hotplate Stirrer XT Packages include a complete XT Set, an additional XT Reactor and two extra Vessel Racks. 2 Reactor Frame 4 Removable Vessel Rack 2 Refluxing Layer 2 Inerting / Purging Manifold 2 Vessel Rack Removal Tool 0 Sealing Gaskets 0 Inner / Piercing Septa 2 Top Plate 0 Multi-Layer Septa, Pre-Scored for Top Plate IKA Hotplate Stirrer, V / 60Hz or 230V / 0Hz Heat Dispersion Adapter for IKA IKA Feedback Control Kit V 230V XT Package - 2 x 6-positions, XT Package - x 6-positions, x 2-positions XT Package - X 6-positions, x 24-positions XT Package - 2 x 2-positions XT Package - x 2-positions, x 24-positions XT Package - 2 x 24-positions XT Package - x 2-positions, x 48-positions info@silicycle.com SiliCycle MiniBlock XT Configuration Guide

7 Individual Items XT Reactor Components Proprietary reactor designed for precision heating and refluxing (temperature range: -70 C to 60 C). For use with magnetic stirrer-heater Available in 6, 2, 24 and 48-positions arrays XT Reactor 6, 2, 24 or 48 -positions Reactor Frame Vessel Rack Refluxing Layer Inerting / Purging Manifold Vessel Rack Removal Tool Sealing Gaskets Inner / Piercing Septa Top Plate Multi-Layer Septa, pre-scored for Top Plate Requires Heat Dispersion Adapter (374206) for Use with IKA Heater-Stirrer See p. 3 for other Heat Transfer Accessories Reaction Vessels Volume Magnetic Stir Bars Shape XT Reactor: 6-positions 24 0 ml XT Reactor: 2-positions 00 ml XT Reactor: 24-positions 00 8 ml XT Reactor: 48-positions 00. ml 0 Egg XT Reactor Frames Supports all XT Reactor Components Reactor Frame: 6 and 2 positions (0 mm Reaction Vessel Height) Reactor Frame: 24 and 48 positions (0 mm Reaction Vessel Height)

8 XT-Plus Reactor The XT-Plus Reaction Block is a unique reaction block with built-in liquid circulation allowing temperature control using a standard heating and cooling recirculator. The XT-Plus Allows: Heating and cooling of reaction vessels in one step, with a single connection Allows precise temperature control, while taking advantage of temperature ramp up and other recirculator features. Small footprint, making the XT-Plus the most compact and space efficient reaction block in its class Temperature Range: -70 C* to 60 C, it is recommended to use the Insulation Wrap ( ) for XT and SiliCycle MiniBlock * Requires a suitable recirculator. XT-Plus Reactors: 6, 2, 24 or 48 -positions Reactor Frame Vessel Rack Refluxing Layer Purging / Evaporating Manifold Vessel Rack Removal Tool Sealing Gaskets Inner / Piercing Septa Top Plate Multi-Layer Septa, Pre-scored for Top Plate See p. 3 for other Heat Transfer Accessories Reaction vessels Magnetic stir bars Volume Shape XT-Plus Reactor: 6-positions 24 0 ml XT-Plus Reactor: 2-positions 00 ml XT-Plus Reactor: 24-positions 00 8 ml XT-Plus Reactor: 48-positions 00. ml 0 Egg Individual XT-Plus Reactor Frames Supports all XT Reactor Components XT-Plus Reactor Frame: 6 and 2 positions (0mm reaction vessel height) XT-Plus Reactor Frame: 24 and 48 positions (0 mm reaction vessel height) info@silicycle.com SiliCycle MiniBlock XT Configuration Guide

9 XT accessories Vessel Racks Readily interchangeable racks in automation friendly microtiter plate formats Windows allow to see the reactions Vessel Rack: 6-positions Vessel Rack: 2-positions Vessel Rack: 24-positions Vessel Rack: 48-positions 3742 Vessel Rack Removal Tool, All Positions Press the button and lock into the rack for removal from frame Inert Manifolds Inerting / Purging Manifold (48-positions) Inert gas manifold can be operated in continuous purging or static pressure modes. Internal septum prevents evaporative loss and facilitates reagent addition or reaction sampling. Includes quick-disconnect gas fittings with shut off valve, allowing inert atmosphere to be maintained at all times. Automation-friendly. Purging / Evaporating (6, 2 and 24-positions) The Purging/Evaporating Manifold provides superior perfomance for maintaining inert atmosphere while providing a cost effective option for evaporating solvents. XT Format Sealing Gaskets (Bottom Gasket) Inert Manifold Internal Septum Rubber Multi-Layer 6-positions positions positions positions Red positions Blue Manifold Upgrade Inerting/Purging to Purging/Evaporating Manifold upgrade enables inert / purge manifolds to have blow down evaporation capability. Upgrades contain the evaporation plate and sealing gasket Upgrade to Purging / Evaporating Manifold: 6-positions Upgrade to Purging / Evaporating Manifold: 2-positions Upgrade to Purging / Evaporating Manifold: 24-positions Top Plate Used for XT closure for reactions not requiring inert atmosphere Top Plate, 6-positions Top Plate, 2-positions Top Plate, 24-positions Top Plate, 48-positions

10 Septa & Gaskets for Inerting / Purging and Purging / Evaporating Manifolds (compatible with vacuum) Disposable septa that ensure reaction vessel sealing and facilitate manual or automated access. The manifolds requires both Inner/Piercing septa and Sealing Gasket. Inner/Piercing Septa Ultra-Pure Natural Rubber Septa / Box Inner/Piercing Septa : 6-positions (for ) Inner/Piercing Septa : 2-positions (for 32009) Inner/Piercing Septa : 24-positions (for ) Inner/Piercing Septa: 48-positions (for and ) Natural Rubber Sealing Gaskets Ultra-Pure Natural Rubber used to firmly seal reaction vessels against the inert/purge or purge/evap manifold Sealing Gasket, 6-positions (for and ) Sealing Gasket, 2-positions (for and ) Sealing Gasket, 24-positions (for and ) Sealing Gasket : 48-positions (for and ) Increased Chemical Resistance Septa & Gaskets (No Vacuum) Advanced sealing composite septa consisting of pure natural rubber, expanded polyethylene (for minimizing solvent loss), and Teflon layer (for chemical resistance). Superior air exclusion to maintain inert atmosphere. Not for use with vacuum/purge cycle inerting. / Box Multi-Layer Sealing Gasket, 48-positions (for and ) Multi-Layer Sealing Gasket, 6-positions (for ) Multi-Layer Sealing Gasket, 2-positions (for 32009) Multi-Layer Sealing Gasket, 24-positions (for ) High Temperature Resistant Septa & Gaskets New Septa consiting of Silicone. Easily pierced with cannulas and syringes. Works with Inerting / Purging and Purging/Evaporating Manifolds. For use with elevated reaction temperatures Septum Silicone : 6, 2 and 24-positions Silicone Sealing Gasket, 6-positions Silicone Sealing Gasket, 2-positions Silicone Sealing Gasket, 24-positions / Box Septa for Top Plate 0 / Box Multi-Layer Septa Composite septa consisting of pure natural rubber, expanded polyethylene, and Teflon layer High Temperature Silicone Multi-Layer Septa Composite septa consisting of pure natural rubber (for easy piercing and resealing),teflon layer (for chemical resistance), and silicone foam for use with elevated temperatures. info@silicycle.com SiliCycle MiniBlock XT Configuration Guide

11 Chemical resistance Excellent Temperature Range Good Poor Acids Concentrated Acids Diluted Alcohols Aliphatic Hydrocarbons Aromatic Hydrocarbons Halogenated Solvents Alkalis Ketones Acids Concentrated Acids Diluted Alcohols Aliphatic Hydrocarbons Aromatic Hydrocarbons Halogenated Solvents Alkalis Ketones Acids Concentrated Acids Diluted Alcohols Aliphatic Hydrocarbons Aromatic Hydrocarbons Halogenated Solvents Alkalis Ketones Acids Concentrated Acids Diluted Alcohols Aliphatic Hydrocarbons Aromatic Hydrocarbons Halogenated Solvents Alkalis Ketones -40 C to 80 C -40 C to 80 C Temperature Range -40 C to 80 C Temperature Range -40 C to 60 C Temperature Range -40 C to 80 C -40 C to 60 C

12 Reflux Layer SiliCycle MiniBlock Heat Transfer Block Quick to install reflux layer block enables efficient condensation Available in 6, 2, 24 or 48 positions arrays. Includes quick-disconnect fittings Reflux Layer (Heat Transfer Block): 6-positions Reflux Layer (Heat Transfer Block): 2-positions Reflux Layer (Heat Transfer Block): 24-positions Reflux Layer (Heat Transfer Block): 48-positions XT consumables Reaction Vessels Borosilicate Glass reaction vessels for XT. Size (mm) Volume (ml) positions Reaction Vessel 34 x positions Reaction Vessel 34 x positions Reaction Vessel 24 x positions Reaction Vessel 24 x positions Reaction Vessel 7 x positions Reaction Vessel 7 x positions Reaction Vessel. x positions Reaction Vessel. x Magnetic Stir Bars Size Reaction vessel type 37 Magnetic Stir in 6-positions 8 38 Magnetic Stir 3/4 in 2-positions 39 Magnetic Stir 3/8 in 24-positions Magnetic Stir Oval mm 48-positions info@silicycle.com SiliCycle MiniBlock XT Configuration Guide

13 Heat Transfer and Mixing IKA Hotplate / Stirrer Components SiliCycle has a close collaboration with IKA and distributes their products, through the SiliCycle MiniBlock XT product line. High quality magnetic stirrer-heater from IKA provides consistent agitation and heat to XT Requires use of Heat Dispersion Adapter (374206) for uniform temperature Temperature feedback control options listed below IKA Hotplate Stirrer, V / 60 Hz 364 IKA Hotplate Stirrer, 230V / 0 / 60 Hz IKA Heat Dispersion Adapter* Focuses heat from IKA unit to XT reactor for uniform temperature distribution to all reaction vessels. 362 IKA Feedback Control Kit* Remote LCD Controller, support structure, extension cable, and RTD temperature probe 363 IKA Feedback Control Upgrade Kit* Extension cable and RTD probe to convert existing IKA units with temperature controller for XT use IKA Recirculating Heat / Cool Base* Insulated temperature control base enables efficient heat transfer from a chiller/recirculator to XT Reactor. Allows temperature controlled cooling and heating. For use with XT block and IKA Stirrer *Temperature control recirculator and IKA Stirrer sold separately XT Low Temperature Bath Insulated tray for sub-ambient temperature control of one XT Reactor Insulated tray maintains dry ice / acetone temperature for approximately four hours without refilling Tray can be placed on top of magnetic stirrers for mixing reaction components XT Block sold separately XT Low Temperature Bath Insulation Wrap Ensures maximal uniformity between reactors when working under extreme temperatures Insulation Wrap for SiliCycle MiniBlock and SiliCycle MiniBlock XT

14 Synthetic Chemists Your Choice for Synthesis SiliCycle MiniBlock SiliCycle MiniBlock is a flexible, easy-to-use tool that maximizes the productivity of synthetic chemists. SiliCycle MiniBlock is the only compact parallel synthesizer that allows synthesis via solid or solution-phase as well as purification to be carried out on the same platform. Originally designed by chemists at Bristol-Myers Squibb, SiliCycle MiniBlock has been further developed by Mettler Toledo and SiliCycle to address a wide range of chemistry methodologies. Chemists can now take advantage of SiliCycle s unique expertise in purification, metal scavenging, catalysis and solid-supported reagents in combination with the SiliCycle MiniBlock to increase productivity while reducing development time. Solution-Phase Synthesis Solid-Phase Synthesis Peptide Synthesis Parallel Purification Inert Conditions Set SiliCycle MiniBlock Synthesizer 2 New Compact Shaking Vacuum Collection Base Tall Tube Extender 2 Air Push Assist Device Counterweight for Shaking Station Air Push Assist Device Tool Kits Maintenance Kit Small Options Heat Transfer Block with Recirculator Manifold Inerting/Purging Manifold Continuous inert gas flow enables air/moisture sensitive reactions. Easily add reagents through the septum layer. Agitation and Resin Washing Customized shaker allow precision vortex mixing of reactions. Built in washing capability allows rapid preparation of resins or washing of products while reaction blocks remain on the shaker. Heating and Cooling Precision heating to 20 C and cooling down to -20 C are achieved using modular heat transfer jackets. Temperature uniformity and reproducibility is within C at 80 C. Platform Flexibility Red and Blue SiliCycle MiniBlock combine to produce 96 compounds. With Just the Turn of a Key Collect products from SiliCycle MiniBlock cleanly and efficiently. Configure Your SiliCycle MiniBlock to Suit Your Needs SiliCycle MiniBlock can synthesize compounds in individual vessels ranging in size from as small as 4 ml up to as large as 40 ml, all delivered into racks with microplate footprints. This flexibility provides a smooth, seamless work-flow from synthesis to screening. Unique Built-In Valve Provides rapid bottom filtration no need to invert or disassemble the reactor. Saves time and prevents cross contamination. 4 info@silicycle.com SiliCycle MiniBlock XT Configuration Guide

15 Procurement Ordering Information : Worldwide Headquarters : SiliCycle Inc. 200 Parc Technologique Blvd. Quebec City, (Quebec) GP 4S6 Canada Fax Orders : Phone Orders : (Toll Free North America Only) Orders : Info@SiliCycle.com When placing an order, specify your purchase order number, price list reference number, product model or part number / description, quantity, shipping and invoicing address, contact name, and telephone number. Terms : All prices are Ex Works. Prices and specifications are subject to change without notice. Prices do not include shipping, handling, taxes and duties. SiliCycle Standard Terms, Conditions, Warranty and Maintenance Agreement Options are available upon request and cover all sales.

16 Custom R&D Services Scavenging Screening Catalysis Services Organic Services Chromatography, Purification & Analytical Services Material Science Services Custom Packing Services Scavenging Technology (Silica-Based) Metal Scavengers Electrophile Scavengers Nucleophile Scavengers Potential Genotoxic Impurities (PGI) Etc. Sample Preparation SPE Cartridges and Well-Plates Micro-SPE Tips QuEChERS Accesssories (Vacuum Manifold, Collection Plates, ) Etc. Other services available Chromatography Irregular Silica Gels Spherical Silica Gels for Preparative Chromatography Chromatographic Phases (C8, NH2 ) Flash Cartridges and Accessories TLC Plates Etc. Organic Synthesis Amide Coupling Oxydation Reductive Amination Other Reagents Available Analytical Chromatography Spherical Silica Gels HPLC and Guard Columns HPLC Column Distributions for Different Manufacturers Etc. Equipments SiliCycle MiniBlock TLC Scanner Vacuum Manifold Other Equipments on Our Website Heterogeneous Catalysis Coupling (Suzuki, Stille, Heck, Sonogashira, Kumada) Debenzylation Hydrosilylation Hydrogenation Oxydation Etc. Consumables Syringe Filters Membrane Filters Vials & Caps Etc. WE PROVIDE SOLUTIONS TO THE GLOBAL CHEMICAL INDUSTRY. Founded in 99, SiliCycle Inc. is a worldwide leader in the development, the manufacturing and the commercialization of high value silica-based and specialty products for chromatography, analytical and organic chemistry. Our business extends to more than fifty countries and our customer portfolio includes companies in a wide range of markets. At SiliCycle, we are at the forefront of the chromatography industry, owing to the extraordinary purity of our silica gels and polymeric sorbents, combined with our capacity to rapidly adapt our products to meet the specific requirements of scientists worldwide. We lead the way in offering innovative first-rate UltraPure products. Our automated manufacturing processes are continuously optimized to ensure high purity and a low percentage of fine particles, thereby guaranteeing optimal performance. With our multi-ton manufacturing capacity, we are your partner of choice for all your analysis, metal removal, catalysis, synthesis, and purification requirements. SiliCycle is also a leading service provider, offering turnkey solutions based on its expertise in organic chemistry, material science, analytical chemistry to name only a few. With stateof-the-art instrumentation in the areas of chromatography, spectroscopy, and manufacturing combined to an applications support laboratory, we are devoted to extend your R&D and make your project a success. SiliCycle has several sales offices in many countries such as China, India, European Union (France & Germany) just to name a few. All products are available worldwide through SiliCycle or via distributors. SiliCycle Inc. Worldwide Headquarters 200, Parc-Technologique Blvd Quebec City (Quebec) GP 4S6 CANADA Tel. : Toll Free : (North America only) Fax : info@silicycle.com SiliCycle Europe European Office europe@silicycle.com SiliCycle China Chinese Office china@silicycle.com SiliCycle India Indian Office india@silicycle.com We are committed to providing you with the highest quality products and services in the industry Information about SiliCycle is available at BRO-008 v - 09/ 20, SiliCycle Inc. Printed in Canada