Introduction to BoroPharm. Contact: Andrew Cipa Office: (888) x4 Mobile: (586)

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Pearl Atkins
6 years ago
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1 Introduction to BoroPharm Contact: Andrew Cipa Office: (888) x4 Mobile: (586)

2 Company Overview Founded in 2003 around a new approach to making boron intermediates for use in Suzuki Couplings BoroPharm has evolved to become a specialty chemical development and manufacturing solutions provider Extremely talented team of chemist 70% PhD s with an average of 15+ years in process development World class facilities Corporate offices (Novi, MI) Research and development labs (Ann Arbor, MI) Large-scale production, former Pfizer facility (Holland, MI)

3 Business Offerings Contract manufacturing services Quantities through 100 metric tons per year Custom synthesis solutions for difficult to source materials Registered starting materials Heterocycle development Complex and advanced intermediates High purity product specifications Process development expertise Route scouting/development Process Optimization Systematic, design of experiment (DOE) approach Supply capability from research through full commercial scale Allows for consistency in supply chain

4 Corporate Objectives 100% Customer Satisfaction!

5 Delivering Customer Satisfaction Guaranteed quality On-time delivery (>98% On-time delivery rate) Fail-safe raw material supply Raw material procurement professionals with deep-rooted connections in emerging markets Every project assigned an alternative raw material supply base, including in-house production Speed to delivery We offer expedited production services designed to get products shipped quickly Frequent progress reports

6 Research and Development Ann Arbor, MI

7 Research and Development Ann Arbor, MI Fully equipped kilo lab (up to 100 L jacketed reactors) Reaction temperatures from -100 to +250 o C Numerous modified Parr hydrogenation instruments linked via automated data collection system 1-4 L High-pressure Hastelloy reactors (up to 3000 psi) 40 L High-pressure Hastelloy reactor (up to 350 psi) High speed auto weighing, bottling, capping and labeling system

8 Research and Development Site Parr Hydrogenators

9 Research and Development Site Auto Weighing Systems

10 Research and Development Site Holland, MI

11 Commercial Production Site Holland, MI 35,000 Liter total capacity (Ability to run 3 shifts, 7 days per week) Reaction temperatures from -100 to +250 o C Hastelloy, stainless steel, and glass-lined jacketed reactors (Sizes range from 200 L - 4,000 L) 3 x 800 L Hydrogenation reactors Production equipment includes: Commercial tray dryers Cogeim filter dryers Rotary cone evaporators Mill press Neutsche jacketed filters Large scale centrifuges

12 Commercial Production Site Holland, MI

13 Delivering Quality Control production of all products Raw materials receipt through product shipment In-house product analysis Karl Fisher titration Computrac moisture analysis Gas chromatography HPLC GC/MS LC/MS NMR ( 1H, 13C, 11B, 15N, 19F, etc.) ICP Elemental Analysis (parts per trillion)

Commercial Production Site With Stellar Safety Record High pressure reactions Borylations Ziegler-Natta catalysis Cross coupling reactions

14 Commercial Production Site With Stellar Safety Record High pressure reactions Borylations Ziegler-Natta catalysis Cross coupling reactions Skraup reaction Chan-Lam coupling Halogenations Hydrogenations (Including asymmetric) Carbonylations Aminations Nitrations Grignards Birch reductions

15 Experience with Heterocycles Imidazolinones Pyrazoles Pyrazoles Thiophenes Triazines Pyrimidines Isoxazoles Oxazoles... And many more

16 Why Would YOU Use BoroPharm? 1) Looking for a product that has not been made commercially before 2) Seeking reliable source for specific product 3) Require optimization work on your synthetic processes 4) Tight campaign schedule requiring quick delivery 5) Secondary supply source 6) Solve internal capacity issues 7) Cannot risk IP theft with overseas suppliers 8) Cannot risk purity or timeline issues

17 How to Contact BoroPharm - Andrew Cipa - Office: (888) x4 - Mobile: (586) acipa@boropharm.com - Domestic call: (248) Fax: (248) sales@boropharm.com -

Process Equipment List

Process Equipment List The detailed lists of process equipment for the facilities used in production at ScinoPharm are attached. These facilities include the: * 1: Kilo Lab. (2 lines) * 2: Mini Plant.