ROTO CUBE SINGLE-POT PROCESSOR
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1 ROTO U SINL-POT PROSSOR
2 ROTO U eveloped in 1984, as a contained solution for the processing of highly active pharmaceutical products, Roto ube technology became the benchmark for single pot process. Roto ube allows the entire process of any type of product, from the loading of raw materials to the discharge of dry granules, carried out in a single, contained bowl, thus eliminating contact between product, operator and the environment. Process in high containment Maximum product yield Reduced risk of contamination Minimum manpower, space and energy Safe use of solvents ccurate detection of process end-point Performing S control system
3 LL IN ON U 1. Jacketed and tilting bowl for reducing drying time lid opening for easy access to the bowl 3..ST. system to reduce drying time 4. Telescopic chopper for maximum batch size flexibility 5. Wash In Place system for accurate cleaning 6. inder spraying for homogeneous liquid distribution 7. Loading of raw material by means of vacuum or gravity 8. ilters to protect the vacuum pump 9. Unloading valve for material discharge 10. In-line milling during granules discharge
4 ROTO U PROSS IRM 1 LOIN 2 MIXIN WT RNULTION WTR S LOOL S RVSNT TMPRTUR SNSITIV OXYN SNSITIV 3 RNULTION MLT RNULTION WX RNULS MOII RLS RNULS LL IN ON OWL 4 RYIN MIL RTION PI NLOSUR IN POLYMRS SLIITION O PI PI OMPLXTION WIT XIPINTS PI RYSTLLIZTION 5 OOLIN 6 RY MILLIN 7 UNLOIN
5 Impeller Telescopic chopper Sampling RYIN IN ROTO U Vacuum, gas stripping system (.ST.), heated and tilting bowl allow drying of wet product with excellent yield and product quality. In this way drying process is very efficient, capable to dry products at low temperature, with efficient solvent recovery and minimum exhausts in the environment. Vacuum drying promotes solvent evaporation at lower temperature. vaporation becomes faster if vacuum is combined with gas stripping system (.ST.), a small stream of air/nitrogen through the product which acts as a carrier of the vapors. The tilting bowl during drying phase moves gently the granules to achieve a good particle size enhancing heat transfer from the bowl to the product. Use of tilting bowl helps either to shorten the drying time.
6 ROTO U OMPT SIN OR PROSS ONTINMNT Roto ube is all in one granulation solution designed to carry out many process steps in the same pot. It is very suitable to work in high containment since product transfers and surface in contact with the product are sensibly reduced. Product loading and unloading can be managed by means of containment valves. WS IN PL U TO ITS OMPT SIN, ROTO U IS LSO ST TO LN N LNIN VLITION IS ILITT. ROTO OR LORTORY Laboratory scale models can be used for formulation and scale up studies to easily achieve production requirements.
7 ROTO U TNIL T ROTO U ROTO U ROTO U ROTO U Model ,200 1,500 2,000 3,000 owl capacity (l) ,200 1,500 2,000 3,000 Product quantity (l) , ,350 1,000-2,000 - hopper height - lifting bowl (mm) ,400 3,870 4, asement height (mm) 2,050 2,100 2,750 3, asement height with lifting bowl (mm) ,300 3, Processing area (mm) ,180 1,325 1,450 1,860 2,150 2,220 2,360 3,700 4,000 - Machine depth (mm) 2,170 2,290 2,880 3,005 3,150 3,650 4,150 4,220 4,360 5,650 5,950 - asement width (mm) 880 1,450 1,700 1,900 2,250 - Tilting width (mm) 1,080 1,300 1,650 2,110 2,650 2,800 3,350 3,400 3,500 4,400 5,400 - ischarge valve height (mm) ,200 1,050 1,200 1,350 1, ischarge valve height - lifting bowl (mm) , , Machine height with opened lid (mm) 1,730 2,000 2,660 2,990 3,370 3,785 4,570 4,650 4,790 5,100 6,000 Impeller speed (rpm) hopper speed (rpm) 700-1,500
8 November RO IM S.p.. reserves the right to make any changes to the described machine characteristics. IM S.p.. IM TIV division Via I Maggio Ozzano milia (ologna) - Italy Tel ax mktg.soliddose@ima.it
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