EcoPrime SMB. Technology enabling chiral separations - efficiently. *patented technology licensed from Baye
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1 EcoPrime SMB Technology enabling chiral separations - efficiently *patented technology licensed from Baye
2 Separating two enantiomers The task of separating two enantiomers (identical structure but mirror image - right hand / left hand), can result in life-saving therapies. While challenging at the lab scale, in a continuous production environment this separation can be even more daunting. YMC Process Technologies (formerly YMC Process Technologies), using the patented approach from Bayer AG, now has a solution for production scale. YMC Process Technologies Image: Wikipedia 2
3 New separation possibilities, cost effective The availability of this design has opened new possibilities and efficiencies for these daunting but important separations. YMC Process Technologies designs, automates and manufactures SMB systems that can swiftly separate chiral compounds at production scale. In 4 zones using 8 chromatography columns the YMC Process Technologies technology deftly separates chiral compounds using columns and media of your choice. LEWA Nikkiso Group For more information contact: ecoprime@ymcpt.com 3
4 Your choice in media and columns; our hardware, software and expertise. The YMC EcoPrime SMB is scaleable and built for the GMP scale production of API s. YMC Shown above: 5 cm column system 4
5 Open-loop concept reduces complexity, cost. Advantage of YMC / BAYER AG* design: No internal recycling pump, thus longer life time of high flow rate pump and columns No need of a third high pressure inlet pump Symmetric SMB equipment design YMC EcoPrime SMB patented technology licensed from Advantage of SMB technique: Continuous (24/7) operation Increased productivity (up to 10 fold) Reduced solvent consumption (90%) *formerly BTS= BAYER TECHNOLOGY SERVICES YMC For more information contact: ecoprime@ymcpt.com 5
6 Advanced fluid control. Simplified. The EcoPrime SMB is engineered without an internal recycling pump, providing a longer life time of high flow rate pump and columns And the patented concept eliminates the need of a third high pressure inlet pump. Reduces complexity, risk and cost. YMC Process Technologies For more information contact: ecoprime@ymcpt.com 6
7 Productivity under pressure LEWA ecoflow metering pumps, the gold-standard in precision at high pressures in demanding environments, are the heart of the EcoPrime SMB. Used in the vast majority of production scale chromatography system over the past 40 years, the LEWA ecoflow pump you can rest assured in the reliability needed by continuous production systems. YMC Process Technologies For more information contact: 7
8 Optimized process design. Sophisticated control. Our history as fluid dynamics experts intersects with the Bayer patented innovation for intelligent separation approach that simplifies SMB. We marry advanced industrial control with a patented process. Electronic records and compliance are built into the manufacturing-ready system. YMC Process Technologies For more information contact: ecoprime@ymcpt.com 8
9 The most reliable fluid delivery Exclusive on EcoPrime SMB: LEWA ecoflow triplex pump Accurate delivery of target flow rate Low pulsation less stress on packed media Close-loop control with mass flow meters (MFM) Frequency and/or stroke adjustment Results: Extract pump in EcoPrime SMB 15 minutes = 15 switches no flow rate variation at switching YMC Process Technologies For more information contact: ecoprime@ymcpt.com 9
10 Proprietary valve design enhances performance Valve is critical to SMB quality: In SMB multiple valves are switched at high frequency (min 0.5 min) 24/7 Avoid pressure spikes at switching Minimal dead volumes Short switching time (< 0,1 s) Long lifetime Maintenance-friendly (exchange of seals) Endurance test illustrates robust design Test Parameters Pressure: - Inlet 8MPa (CV1) - Outlet 6MPa (CV2) 500,000 times open-close at pressure Result: Zero fail High endurance, low hold-up fast acting: Design exclusively for EcoPrime SMB. YMC Process Technologies For more information contact: ecoprime@ymcpt.com 10
11 Performance testing results show fine separation Initial Conditions Final Conditions Sample Ratio (%) Conc. (g/l) Weight (mg/min) Cycle Raff Ext Raff Ext Raff Ext Eluent 16 ND ND Feed Extract ND Raffinate ND Waste 16 ND ND Exceptional test results (generic enantioseparation) YMC Process Technologies
12 HMI operator friendly, robust manufacturing style Main screen with flow diagram Color-marking flow paths Feed: green Eluent: blue Raffinate: yellow Extract: magenta Method management Historic trends Alarm list Event list Login screens / Access control YMC Process Technologies 12
13 Process Development - straightforward Simply define parameters/boundaries for your SMB process Resin and solvent composition Feed concentration, temperature Bed height Cycle time Number of columns, columns/zone Flow rates of the four pumps Feed Extract Raffinate Eluent Intelligent software on EcoPrime SMB makes process development straightforward YMC Process Technologies 13
14 Historic trends automatically configured Monitoring of process trends during operation --- saved in historian YMC Process Technologies 14
15 Column testing is individualized and recorded Each individual column - information saved in data base YMC Process Technologies For more information contact: ecoprime@ymcpt.com 15
16 Example performance testing at end user Sample Ratio (%) Conc. (g/l) Flow (ml/min) Cycle Raff Ext Raff Ext Eluent 0 ND ND 9.7 Feed Extract Raffinate Step: Waste sec YMC Process Technologies Surpasses customer requirements 16
17 How teamwork results in a world-class system optimized for your application This extraordinary technology is the collaboration of the expert teams in YMC Japan and YMC s daughter company YMC Process technologies. Building on the Bayer licensed SMB approach YMC global organization has melded their expertise in separations science, automation and hardware to produce the EcoPrime SMB. This team takes your information and produces a system individualized to your application based on the EcoPrime SMB technology framework worked out over years of design and pilot work. The YMC team leads the design discussion and delivers the automation / control portion of the EcoPrime SMB. The YPT team delivers the pump and fabricates the fluid flow portion of the hardware and lending FAT facilities to the YMC engineers who follow the system to the field supporting installation. A single source leveraging unique original technology expertise globally. The result? Customers that are impressed and with new cost effective ways to expand their drug therapy market. German, Japanese and American know-how are represented by the YMC Process Technologies EcoPrime SMB team pictured here YMC Process Technologies For more information contact: ecoprime@ymcpt.com 17
18 Custom size to your need Our patented design can be applied to pilot to production capacity. Get in contact with us to size to your separation. Minimized dead volumes to reduce band broadening effects & avoid asymmetric design between columns YMC Process Technologies For more information contact: 18
19 EcoPrime SMB Established robust technology customer proven patented technology Substantial cost / time savings up to 10 fold productivity increases up to 90 % buffer consumption reducing CSP amount Seamless, fast scale up bench top batch to production scale accelerated implementation Minimizing risk due to continuous operation scale reduction Our YMC SMB specialists YMC Process Technologies For more information contact: ecoprime@ymcpt.com 19
20 Industrial-scale chromatography systems by LEWA Batch chromatographic systems YMC EcoPrime LPLC using LEWA digital drive technology Multi-column continuous chromatographic systems YMC EcoPrime SMB licensed from YMC EcoPrime Twin based on ChromaCon s CaptureSMB license 20
21 The future provides broader solutions for our customers The innovation and growth of this and other EcoPrime product lines has attracted the attention of leading technology suppliers and users. YMC Co., Ltd. assumed all rights and production for the EcoPrime suite of systems in late 2018 from LEWA-Nikkiso America, Inc. This acquisition brings a broad spectrum of chromatographic resins, and columns ideal for large and small molecule purification. More about this new chapter for EcoPrime at Ordering information To order the EcoPrime SMB system, please contact your regional sales representative. YMC Process Technologies Bio/Pharma Systems Group 8 Charlestown Street Devens, MA Tel: sales@ymcpt.com Headquarters: YMC Co., Ltd. YMC Karasuma-Gojo Building 284 Daigo-cho, Karasuma Nishiiru, Gojo-dori, Shimogyo-ku, Kyoto, Japan Tel: FAX: sales@ymc.co.jp Regional Offices: YMC logo is a trademark of YMC Co. Ltd. ChromaCon, Contichrom, ChromIQ and CaptureSMB are registered marks of ChromaCon AG. Rockwell FactoryTalk is a registered mark of Rockwell Automation. LEWA Creating Fluid Solutions and LEWA logoare marks of LEWA GmbH DeltaV is a registered mark of the Emerson Process Management family of companies. All goods and services are sold subject to the terms and conditions of sale of the company within YMC which supplies them. A copy of these terms and conditions is available on request. Contact your local YMC representative for the most current information. Subject to change without notice. Data herein does not constitute a guarantee of performance YMC Process Technologies. All rights reserved. 21
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