Product: Isosorbide. Product: Isosorbide Flow Diagram

Transcription

1 Product: Isosorbide dehydration p-toluene Sulphonic Acid + 2 H 2 O Sorbitol Isosorbide Name Empirical Formula Mol. Weight Sorbitol C 6 H 14 O Liquid Isosorbide C 6 H 10 O Solid Water 2H 2 O 36 Liquid Product: Isosorbide Flow Diagram 2.5 kg Sorbitol 70% solution 1.08 kg Isosorbide 0.02 kg p-toluene Sulphonic Acid Dehydration Distillation 1.1 kg water to ETP 0.01 kg Sodium acetate anhydrous 0.35 kg distillation residue to CHWTSDF 5000 L SS, C 1.08 kg Isosorbide Washing 1 kg Isosorbide (Product) 0.05 litres Methanol Centrifuging 0.12 kg ML to ETP 48 SS Centrifuge Equipment Washing: 2 litres per kg

2 Production capacity: 5 MT/month Waste Type Quantity/kg Quantity in KL Quantity in Treatment per month KL per day Effluent Liquid 3.22 kg To ETP Distillation Residue Solid 0.35 kg To CHWTSDF Gaseous emissions Water vapour 0.10 kg To atmosphere Equipment and Utilities: L SS Distillation Unit 2. Thermopack: kcal/hr SS Centrifuge

3 Product: Diluted Isosorbide Dinitrate dehydration p-toluene Sulphonic Acid + 2 H 2 O Sorbitol Isosorbide 2HNO 3 H 2 SO 4 Diluted Isosorbide Dinitrate Lactose Blending + 2 H 2 O Isosorbide Dinitrate Name Empirical Formula Mol. Weight Sorbitol C 6 H 14 O Liquid Isosorbide C 6 H 10 O Solid Nitric Acid HNO 3 63 Liquid Sulphuric Acid H 2 SO 4 98 Liquid Isosorbide Dinitrate C 6 H 8 N 2 O Solid

4 Product: Diluted Isosorbide Dinitrate Flow Diagram (Pure Product- 6 MT/M) 2.5 kg Sorbitol 70% solution 1.08 kg Isosorbide 0.02 kg p-toluene Sulphonic Acid Dehydration Distillation 1.1 kg water to ETP 0.01 kg Sodium acetate anhydrous 0.35 kg distillation residue to CHWTSDF 5000 L SS, C 1.08 kg Isosorbide Washing 1 kg Isosorbide 0.05 litres Methanol Centrifuging 0.12 kg ML to ETP 48 SS Centrifuge 1 kg Isosorbide 0.1 kg vapor loss to scrubber 2 kg HNO 3 70% kg HNO 3 98% Nitration 4 kg Sulphuric Acid Reaction Mass 800 L SS, 5-15 C Precipitation kg Sulphuric Acid + 30 litres water Washing & Unreacted isosorbide and Su Nitric Acid + drying Water to ETP 2500 L SS, C 1.1 kg ISDN Crude 1 kg ISDN pure 0.66 kg Acetone Purification & Drying kg Effluent to ETP 10 litres water 2500 L SS, Ambient, 50 C ISDN pure Lactose Pulverizing Blending Diluted Isosorbide Dinitrate SS Pulverizer and Mixer Equipment washings: 10 litres per kg of product

5 Production capacity: 15 MT/month of Diluted Isosorbide Dinitrate (6 MT/M Pure Product) Waste Type Quantity/kg Quantity in KL Quantity in Treatment per month KL per day Effluent Liquid kg To ETP (15% TDS) Distillation Residue Solid 0.35 kg To CHWTSDF Gaseous emissions Water vapour + reaction vapours 0.10 kg To scrubber Equipment and Utilities: L SS Distillation Unit 2. Thermopack: kcal/hr SS Centrifuge L SS Reactor TR Chiller (Glycol) L SS Reactor 7. SS Dryer 8. SS Pulverizer 9. SS Mixer 10. Steam boiler: 200 kg/hr 11. Nutch filter

6 Product: Diluted Isosorbide-5-Mononitrate dehydration p-toluene Sulphonic Acid + 2 H 2 O Sorbitol Isosorbide CH 3 COONa (CH 3 CO) 2 O HNO 3 (CH 3 CO) 2 O Isosorbide-2-Acetate-5-Nitrate + CH 3 COOH + CH 3 COOH Isosorbide-2-Acetate NaOH CH 3 ONa Lactose Blending Diluted Isosorbide-5-Mononitrate Isosorbide-5-Mononitrate + CH 3 COONa

7 Name Empirical Formula Mol. Weight Sorbitol C 6 H 14 O Liquid Isosorbide C 6 H 10 O Solid Acetic Anhydride (CH 3 CO) 2 O 102 Liquid Isosorbide-2-Acetate C 8 H 12 O Soid Acetic Acid CH 3 COOH 60 Liquid Nitric Acid HNO 3 63 Liquid Isosorbide-2-Acetate- C 8 H 11 O 7 N 233 Solid 5-Nitrate Sodium Hydroxide NaOH 40 Solid Sodium Methoxide CH 3 ONa 54 Solid Sodium Acetate CH 3 COONa 82 Solid Isosorbide-5- Mononitrate C 6 H 9 O 6 N 191 Solid Product: Diluted Isosorbide-5-Mononitrate Flow Diagram 3.25 kg Sorbitol 70% solution 1.4 kg Isosorbide kg p-toluene Sulphonic Acid Dehydration Distillation 1.42 kg water to ETP kg Sodium acetate anhydrous kg distillation residue to CHWTSDF 2500 L SS, C 1.4 kg Isosorbide Washing 1.29 kg Isosorbide 0.05 litres Methanol Centrifuging 0.15 kg ML to ETP 48 SS Centrifuge 1.29 kg Isosorbide 1.29 kg Isosorbide-2-Acetate 0.95 kg Acetic Anhydride Acetylation Distillation 0.26 kg Acetic Acid (by-product) to sale kg Sodium acetate anhydrous 0.77 kg distillation residue to CHWTSDF 2500 L SS, C

8 1.29 kg Isosorbide-2-Acet 1500 L SS, 5-15 C 0.2 kg vapor loss to scrubber 1.43 kg Acetic Anhydride Nitration 0.57 kg Nitric Acid 98% 3.09 kg Reaction Mass 8.18 kg Effluent to ETP Extraction 0.45 kg Methylene Chloride kg recycled MeCL kg Spent charcoal to CHWTSDF 3000 L SS, 10 C 7.1 litres water kg charcoal 7.36 kg Reaction mass MeCl 2 Extract Distillation 2000 L SS C, 8 hrs 4.9 kg MeCl 2 (reuse) 2.01 kg Reaction Mass & 0.45 MeCl2 loss to scrubber Distillation 2000 L SS 2.23 kg Methanol (reuse for 10 batches ) 2.4 kg Methanol kg Charcoal C,8Hrs 0.04 kg Spent Charcoal to CHWTSDF kg Sodium Methoxide 1.75 kg Reaction Mass kg to scrubber 12.1 kg Toluene (reuse) kg losses Extraction 0.15 kg Reaction 12.3 kg Toluene 2500 L SS 70 C, 3 hr Waste 1.6 kg ISMN Crude 2.4 kg Water Recrystallization Drying SS Crystallizer, SS Centrifuge, SS Dryer, SS Pulverizer, SS Mixer 2.2 kg Water to ETP 1 kg ISMN 0.8 kg evaporation loss to scrubber Diluted Isosorbide-5-Mononitrate Lactose Blending Equipment washings: 25 litres per kg of product

9 Production capacity: 13 MT/month of Pure Isosorbide Mononitrate Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid kg To ETP Distillation Residue Solid kg To CHWTSDF Solid Hazardous Solid 0.15 kg 1.95 MT To CHWTSDF Waste Gaseous emissions Water vapour kg To scrubber + Solvents + reaction vapours By products Acetic Acid Sale to authorized dealer Equipment and Utilities: L SS Distillation Unit 2. Thermopack: kcal/hr SS Centrifuge L SS Distillation Unit L SS Reactor TR Chilling Unit (Glycol) L SS Reactor L SS Distillation Unit L SS Distillation Unit L SS Reactor 11. SS Crystallizer SS Centrifuge 13. SS Dryer 14. SS Pulverizer 15. SS Mixer 16. Sparkler filter/nutch filter 17. Steam boiler: 400 kg/hr

10 Product: Dimethyl Isosorbide dehydration p-toluene Sulphonic Acid + 2 H 2 O Sorbitol Isosorbide 2NaOH (CH 3 ) 2 SO 4 Dimethyl Isosorbide + Na 2 SO H 2 O Name Empirical Formula Mol. Weight Sorbitol C 6 H 14 O Liquid Isosorbide C 6 H 10 O Solid Dimethyl Sulphate (CH 3 ) 2 SO Liquid Sodium Hydroxide NaOH 40 Solid Dimethyl Isosorbide C 8 H 14 O Liquid Sodium Sulphate Na 2 SO Solid

11 Product: Dimethyl Isosorbide Flow Diagram 2.5 kg Sorbitol 70% solution 1.08 kg Isosorbide 0.02 kg p-toluene Sulphonic Acid Dehydration Distillation 1.1 kg water to ETP 0.01 kg Sodium acetate anhydrous 0.35 kg distillation residue to CHWTSDF 5000 L SS, C 1.08 kg Isosorbide Washing 1 kg Isosorbide 0.05 litres Methanol Centrifuging 0.12 kg ML to ETP 48 SS Centrifuge 1 kg Isosorbide 0.1 kg losses to scrubber 1.26 kg Sodium Hydroxide Methylation 3 kg Dimethyl Sulphate 2500 L SS 2.05 kg water 70 C (ETR) Reaction Mixture 6 kg water 3.6 kg Methylene Chloride Extraction 2500 L SS, C kg ML to ETP 4.7 kg Extract in MeCl 2 Distillation 3.3 kg MeCl 2 for reuse losses to scrubber 2500 L SS C 10 hrs 1.1 kg Crude Dimethyl Isosorbide High Vacuum Distillation 1 kg Dimethyl Isosorbide 0.1 kg Distillation Residue 1500 L SS, C 6 hrs Equipment washings: 7 litres per 1 kg of Dimethyl Isosorbide

12 Production capacity: 5 MT/month of Dimethyl Isosorbide Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid kg To ETP Distillation Residue Solid 0.45 kg To CHWTSDF Gaseous emissions Water vapour and reaction vapours 0.4 kg To scrubber Equipment and Utilities: L SS Distillation Unit 2. Thermopack: kcal/hr SS Centrifuge L SS Distillation Unit L Distillation Unit

13 Product: Diluted Nitroglycerin (1.5 MT Pure) HNO 3 / H 2 SO 4 + 3H 2 O 5-10ºC Glycerin Nitroglycerin Name Empirical Formula Mol. Weight Glycerin C 3 H 8 O 3 92 Liquid Nitric Acid HNO 3 63 Liquid Sulphuric Acid H 2 SO 4 98 Liquid Nitroglycerin C 3 H 5 N 3 O Liquid Product: Diluted Nitroglycerin Flow Diagram 0.75 kg Glycerin 1 kg Nitroglycerin 1.31 kg HNO 3 70 % kg HNO 3 98% Nitration 0.05 kg Losses to scrubber 2.8 kg Sulphuric Acid kg ML to ETP 100 kg Water Washing 0.2 kg CaCl 2 Diluted Nitroglycerin Blending with Lactose Equipment: 5 L Glass Reactor, 5-10 C Equipment washings: 2 litres per kg of Nitroglycerin

14 Production capacity: 25 MT/month of Diluted Nitroglycerin Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid kg To ETP Gaseous emissions Reaction vapours 0.05 kg To scrubber Equipment and Utilities: 1. 5 L Glass Reactors 2. Chilling Unit: 5 TR (Glycol) 3. SS Mixer

15 Product: Carbimazole Vinyl acetate CH 3 OH, Soda ash + Br 2 + CH 3 COOCH 3 + CH 3 OH Bromoacetaldehyde Dimethyl acetal CH 3 OH CH 3 NH 2 KOH + CH 3 OH (Methylamino)acetaldehyde Dimethyl acetal Acetone NH 4 SCN Mercazole (Methimazole) Pyridine ClCOOC 2 H 5 Acetone Carbimazole

16 Name Empirical Formula Mol. Weight Vinyl acetate monomer C 4 H 4 O 2 86 Liquid Bromine Br Liquid Methanol CH 3 OH 32 Liquid Bromoacetaldehyde BrCH 2 CH(OCH 3 ) Liquid Dimethyl Acetal (BAMA) Methyl Acetate CH 3 COOCH 3 74 Liquid Monomethyl Amine CH 3 NH 2 31 Gas (Methylamino)acetaldehyde CH 3 NHCH 2 CH(OCH 3 ) Liquid Dimethyl Acetal (MAMA) Potassium Bromide KBr 89.9 Solid Ammonium Thiocyanate NH 4 SCN 76 Solid Mercazole (Methimazole) C 4 H 6 N 2 S 114 Solid Ethyl Chloroformate ClCOOC 2 H Liquid Carbimazole C 7 H 10 N 2 O 2 S 186 Solid Pyridine C 5 H 5 N 79.1 Liquid Acetone CH 3 COCH 3 58 Liquid

17 Product: Carbimazole Flow Diagram 6.64 kg Vinyl Acetate Monomer 5.64 kg BAMA 12.5 kg Bromine Bromination 3 kg Methyl acetate 12.1 kg Methanol 8 kg Methanol recycle 2.14 kg Soda Ash kg Aqueous Effluent to ETP 71.4 kg Water 7 kg Sodium Bromide to ETP 5.64 kg BAMA kg MAMA kg MMA 40% solution kg Methanol recycle 6.32 kg Methanol Amination kg Effluent to ETP 8.3 kg KOH 3 kg Potassium Bromide to ETP 10 kg water kg MAMA 0.98 kg Mercazole 0.93 kg Acetone 1.18 kg Ammonium Thiocyanate Cyclization Distillate Acetone ML for product recovery 0.98 kg Mercazole 1.25 kg Carbimazole crude 1.16 kg Ethyl chloroformate kg effluent to ETP 0.86 kg Pyridine Esterification 3.10 kg Acetone 7.86 kg Water 1.25 kg Carbimazole crude 1 kg Carbimazole 0.18 kg charcoal Spent Charcoal 0.18 kg 7.14 kg Acetone Purification Acetone ML for recovery Equipment washings: 15 litres per kg of carbimazole

18 Production capacity: 2.5 MT/month of Carbimazole Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid 145 kg To ETP Solid Waste Spent Charcoal To CHWTSDF Equipment and Utilities: L Glass Distillation Units 15 Nos. 2. Thermopack: kcal/hr 3. Chilling unit: 5 TR (Glycol) SS Centrifuge 5. SS Dryer 6. SS Pulverizer 7. SS Mixer

19 Product: Methimazole Vinyl acetate CH 3 OH, Soda ash + Br 2 + CH 3 COOCH 3 + CH 3 OH Bromoacetaldehyde Dimethyl acetal CH 3 OH CH 3 NH 2 KOH + CH 3 OH (Methylamino)acetaldehyde Dimethyl acetal Acetone NH 4 SCN Mercazole (Methimazole)

20 Product: Methimazole Flow Diagram 7.75 kg Vinyl Acetate Monomer 6.58 kg BAMA kg Bromine Bromination 3.5 kg Methyl acetate 14.2 kg Methanol 9.33 kgmethanol recycle 2.5 kg Soda Ash 94.7 kg Aqueous Effluent to ETP 83 kg Water 7.92 kg Sodium Bromide 6.58 kg BAMA 2.30 kg MAMA kg MMA 40% solution kg Methanol recycle Amination kg Methanol kg Water to ETP 9.67 kg KOH 3.51 kg Potassium Bromide 10 kg Water 2.30 kg MAMA 1.15 kg Methimazole crude 1.08 kg Acetone 1.38 kg Ammonium Thiocyanate Cyclization Distillate Acetone ML for product recovery 1.15 kg Methimazole crude 1 kg Methimazole 0.21 kg charcoal Spent Charcoal 4.6 kg Acetone Purification Acetone ML for recovery Equipment washings: 15 litres per kg of methimazole

21 Production capacity: 2.5 MT/month of Methimazole Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid kg To ETP Solid Waste Spent Charcoal To CHWTSDF Equipment and Utilities: L Glass Distillation Units 12 Nos. 9. Thermopack: kcal/hr 10. Chilling unit: 5 TR (Glycol) SS Centrifuge 12. SS Dryer 13. SS Pulverizer 14. SS Mixer

22 Other utilities: 1. Cooling towers: 100 TR x 1, 150 TR x 1, 50 TR x 1 2. Process Scrubbers As and where required 3. RO Water Systems: 2 x 2000 litres/hour 4. Air Handling Units (with temperature and humidity control): Section-wise for each production block 5. Generator(s) 6. Backup chilling system: 10 TR (Glycol) 7. Fire fighting system with main pump, booster pumps and diesel powered backup pump Storage Tanks: 1. Underground Storage tanks for Methanol and Toluene- 2. Water tank for fire fighting system- 3. Process Water tank 4. Domestic Water tank