BIAZZI Group. Presentation of the

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1 Presentation of the BIAZZI Group 25, Ch de la Tavallaz, CH-1816 Chailly s/montreux, Switzerland Tel.: Telefax:

2 THE BIAZZI GROUP TODAY BIAZZI Family (Switzerland) BIAZZI SA Engineering Chailly, Montreux (Switzerland) DIPHARMA Pharma Chemicals Udine (Italy) DIPHARMA Manufacturing Udine (Italy) DIPHARMA Manufacturing Milan (Italy) DIPHARMA FRANCIS Pharma Chemicals Milan (Italy) AMINO CHEMICALS Manufacturing (Malta) 2

3 BIAZZI ENGINEERING SWITZERLAND MAIN PRODUCT LINES PROJECTS AND PLANTS FOR THE CHEMICAL INDUSTRY Hydrogenation technology Nitration technology Explosives technology SINCE 1991 OVER 57 PROJECTS SINCE 1946 OVER 40 PROJECTS SINCE 1936 OVER 250 PROJECTS 3

4 BRIEF PRESENTATION OF BIAZZI GROUP BIAZZI GROUP is private and fully controlled by the BIAZZI family TOTAL PERSONNEL : approx. 470 TOTAL ANNUAL TURNOVER : approx. 110 MM EUR 4

5 Hydrogenation Technology 25, Ch de la Tavallaz, CH-1816 Chailly s/montreux, Switzerland Tel.: Telefax:

6 LIMITATIONS OF TRADITIONAL INDUSTRIAL HYDROGENATION PLANTS Limited heating / cooling Limited mixing Not homogeneous distribution Difficult scale-up High catalyst consumptions Long batch times = by-products Reproducibility not assured Potential tightness and leaking problems 6

7 BIAZZI HIGH-PERFORMANCE HYDROGENATION REACTOR 7

8 BIAZZI MAGNETIC DRIVE BMD-40 through 100 8

9 HIGH-PERFORMANCE GAS-LIQUID REACTOR: BATCH TIME COMPARISON Reaction Heating Cooling Standard system Feeding Emptying Long batch time t BIAZZI system t Short batch time = smaller equipment 9

10 OUR EXPERIENCE : COMPLETE PLANTS /SAFETY 10

11 OUR EXPERIENCE BASE AND CUSTOM SOLUTIONS: ERRECTION OF SKID ON SITE 11

12 OUR EXPERIENCE BASE AND CUSTOM SOLUTIONS: ERRECTION OF SKID ON SITE 12

13 DIRECT SCALE-UP / SCALE-DOWN Laboratory Reactor: Up to 50 m 2 /m L bar (250 bar) Industrial Reactor: Up to 20 m 2 /m 3 (7 m 2 /m 3 for cgmp) 100L 50 m bar (250 bar) Very high efficiency Direct Scale-up from laboratory to industrial size: No pilot plants needed Faster time to market Heating cooling jacket Direct Scale-down from industrial size: New product introduction (multipurpose plants), Toll manufacturing Extremely high gas recirculation 13

14 BENEFITS OF BIAZZI HYDROGENATION TECHNOLOGY High-performance reactor technology Reduced batch cycle time Higher throughput and/or Reducedcatalyst load Catalyst savings Higher yield Better plant economics Better downstream economics Less solvent Higher throughput Longer catalyst life-time Catalyst savings Direct Scale-up Scale-down Shorter time to market No pilot trials needed Safe and reliable introduction of new processes Verification of raw material, catalyst, etc Cheap and off-line process improvement Scale-up guarantees for in-house tested processes Experience base State of the art hydrogenation plant Highest safety standard Most economic plant design Most ergonomic plant design Reduced project risks Shortest time to market Custom tailored solution 14

15 3D VIEW OF BIAZZI HYDROGENATION REACTOR 15

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