Outside of the Walls. Protocol & SOP Changes & Audit Checklists. Outside The Walls - Section 5 1
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1 Outside of the Walls Protocol & SOP Changes & Audit Checklists Outside The Walls - Section 5 1
2 The Protocol It tells what is going to be done it DRIVES the study It should be signed & dated by the Study Director (and approved by the Sponsor) Become familiar with it Outside The Walls - Section 5 2
3 The Protocol Planned change Amendment Must be documented with reasons Recommend: Show original information (if any) & what it was changed to / reason Only the Study Director can alter the direction of the protocol Signed / dated by Study Director Filed with the protocol Should be communicated to all applicable staff Outside The Walls - Section 5 3
4 The Protocol Amendment With advanced notice, some things can be documented as an amendment before they occur Example: unforeseen schedule conflict for a timed harvest If approved by the Study Director Outside The Walls - Section 5 4
5 The Protocol Unplanned change Deviation Must be documented with reasons & communicated to the Study Director Recommend: Show original information, what occurred/reason, impact on study Signed / dated by Study Director File with the protocol Outside The Walls - Section 5 5
6 The Protocol Remember The importance of notes in protocol changes s, telephone logs These should be signed / dated & included in study file Outside The Walls - Section 5 6
7 SOPs Unplanned changes deviations Must be documented Recommend: Original information, what occurred & reason, impact on study Authorized by the study director Filed in the raw data Outside The Walls - Section 5 7
8 SOPs Planned changes Amendments Must be documented with reasons Recommend: Show original information (if any) & what it was changed to / reason Authorized by Study Director Filed with the raw data Should be communicated to all applicable staff Significant changes should be approved in writing by management revise the SOP Outside The Walls - Section 5 8
9 Outside The Walls - Section 5 9
10 Useful auditing tool Checklists can be used for : Protocol reviews Data / notebook reviews Final report reviews Phase audits Outside The Walls - Section 5 10
11 They can be general Use the GLPs to develop your checklist They can be specific Use the GLPs & your SOPs to develop your checklist Outside The Walls - Section 5 11
12 What can be on a checklist??? Identify what you are auditing Study title Study number / Project number Phase or activity inspected Date of Audit Auditor PI & Person performing the work Outside The Walls - Section 5 12
13 Protocol Number Do you have a complete copy of the protocol? Is the protocol signed / dated? Do you know what the QA responsibilities are per protocol? Outside The Walls - Section 5 13
14 SOPs Identify what SOPs will be used for the audit Are they adequate in topic and scope of the work Are they approved / reviewed at the appropriate frequency Are they available to the appropriate staff Were the SOPs followed Outside The Walls - Section 5 14
15 Checklist for Auditing Personnel Received GLP training CVs, job descriptions, & training records / read & understood SOPs are on file & up-to-dates Data recorded properly Outside The Walls - Section 5 15
16 Equipment Identify equipment used Has it been verified / calibrated / cleaned as per SOP Logbooks / records are up-to-date Outside The Walls - Section 5 16
17 Test Substance As per protocol / COA /COC Labeled (name, batch #, expiration date, storage conditions) & handled properly Stored properly per protocol & label Outside The Walls - Section 5 17
18 Checklists for auditing Test Substance (continued) Usage documented Preparation for application Carrier / vehicles / adjuvants documented Labeled (name, lot #, expiration date, storage conditions) Application Outside The Walls - Section 5 18
19 Test Systems As specified in the protocol Maintenance Outside The Walls - Section 5 19
20 Control & Treated Plots As per protocol (size, layout, location ) Identified Location identified / documented Pesticide history / maintenance chemicals documented Outside The Walls - Section 5 20
21 Phase audited (application, sampling, ) Study specific requirements List important aspects of these activities documentation Outside The Walls - Section 5 21
22 Have space for audit notes Audit findings / observations Responses to QA findings / observations Signatures / dates (coversheet) Remember to make it work for you! Outside The Walls - Section 5 22
23 Thank you Outside The Walls - Section 5 23
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