Immunohistochemistry Detection Systems ImmunoDetector PolyDetector PolyDetector Plus

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1 Immunohistochemistry Detection Systems ImmunoDetector PolyDetector PolyDetector Plus A wide array of highly sensitive biotin & micro-polymer based detection systems. For use in clinical and research laboratories. Bio SB Inc, 69 Santa Felicia Drive, Santa Barbara, CA 97, USA Tel (USA): Tel (Int): Fax:

Bio SB IHC Detection Systems IHC Detection Systems Bio SB offers the molecular pathology community a robust and diverse array of

With a variety of biotin/streptavidin & micro-polymer detection chemistries, Bio SB is sure to have a detection system to meet

Paired with the large array of Bio SB antibodies, chromogens, and ancillaries, Bio SB offers laboratories a sensitive and

About Bio SB Since its inception in Santa Barbara, California 5 years ago, Bio SB has developed an in-depth knowledge of

Bio SB has produced high quality antibodies, ancillaries and detection chemistries since 998 in an ISO 85:00 and FDA cgmp 80

The mission of Bio SB is provide high quality & cost effective immunochemicals to researchers, clinicians, and Bio SB is

HRP labeled strepatividin or micropolymer, and chromogen of choice.

2 Bio SB IHC Detection Systems IHC Detection Systems Bio SB offers the molecular pathology community a robust and diverse array of biotin and micropolymer based detection systems for use in both research and clinical laboratories. With a variety of biotin/streptavidin & micro-polymer detection chemistries, Bio SB is sure to have a detection system to meet your needs. Paired with the large array of Bio SB antibodies, chromogens, and ancillaries, Bio SB offers laboratories a sensitive and versatile catalog of IHC products at a competitive price. About Bio SB Since its inception in Santa Barbara, California 5 years ago, Bio SB has developed an in-depth knowledge of immunohistochemical research, production, and manufacturing. Bio SB has produced high quality antibodies, ancillaries and detection chemistries since 998 in an ISO 85:00 and FDA cgmp 80 approved facility. The mission of Bio SB is provide high quality & cost effective immunochemicals to researchers, clinicians, and Bio SB is headquartered in Santa Barbara, California 5 minutes from UCSB. Bio SB is an FDA/ISO 85 certified facility. pathologists globally. Presentation All Bio SB Detection systems are manufactured according to FDA and ISO guidelines to ensure a high quality In-vitro diagnostic kit. All Bio SB detection systems come complete with an endogenous peroxidase blocker, biotin/polymer linker (if applicable), AP or HRP labeled strepatividin or micropolymer, and chromogen of choice. Peroxidase Block Biotin or Polymer Link (if applicable) Label Substrate Chromogen Bio SB Antibodies Compliment your Bio SB Detection chemistry with a selection of over 0 IVD and ASR antibodies from Bio SB. All antibodies are available in concentrate or prediluted format and validated for use with Bio SB detection systems. Tinto Prediluted Antibodies ml Tinto Predilute (0 tests) 7 ml Tinto Predilute (70 tests) Tinto Predilute (50 tests) No need for antibody titering or optimization. Compatible with biotin or micro-polymer based detection systems. Concentrated Antibodies 0. ml Concentrate 0.5 ml Concentrate ml Concentrate Cost effective solution. Compatible with biotin or micro-polymer based detection systems. Can be optimized to meet the needs of each laboratory. Tinto Prediluted antibodies & control slides ml, 7mL, and 5mL presentations

Bio SB ImmunoDetector Technology IHC ImmunoDetector Detection Systems The Bio SB ImmunoDetector is a highly sensitive

sections, cytosmears, and cell preparations.

Biotin-streptavidin immunohistochemistry detection technology.

mouse/rabbit configurations. All kits manufactured according to US FDA and ISO 85 Guidelines.

3 Bio SB ImmunoDetector Technology IHC ImmunoDetector Detection Systems The Bio SB ImmunoDetector is a highly sensitive biotin-streptavidin detection system that allows for the demonstration of antigens in paraffin-embedded tissue, cryostat sections, cytosmears, and cell preparations. The increased sensitivity of the ImmunoDetector Detection System allows for rapid staining procedures without compromising the quality of stains. The ImmunoDetector Detection System is a universal detection system which is suitable for use with mouse or rabbit primary antibodies. Compared with competing avidin-biotin based detection systems, the immunodetector generates higher sensitivity and specificity at a competitive price. Bio SB ImmunoDetector Overview 5 Substrate Chromogen Available in HRP or AP configurations. Biotin-streptavidin immunohistochemistry detection technology. Universal ready-to-use formulation detects mouse or rabbit antibodies. Optimized for use with Bio SB Tinto Prediluted antibodies. Kits available in mouse/rabbit configurations. All kits manufactured according to US FDA and ISO 85 Guidelines. Antigen Streptavidin HRP/AP Biotin Link Anti-M/R Primary Antibody Peroxidase Block Recommended DAB Protocol Above: Bio SB ImmunoDetector mechanism of action. ImmunoWasher ImmunoWasher ImmunoWasher ImmunoWasher ImmunoWasher ImmunoWasher Deparaffinize Block Antibody Link Label 5 DAB 6 Hematoxylin 5 min min. 0 min. 0 min. 5-0 min. 0 seconds Presentations & umes CK RMab DAB Protocol Time 60 minutes ImmunoDetector HRP/DAB ume BSB 000 BSB 000 BSB 0005 BSB 0007 BSB 0009 ImmunoDetector HRP/AEC BSB 000 BSB 000 BSB 0006 BSB 0008 BSB 000 ImmunoDetector AP BSB 008 BSB 008 BSB 008 BSB 0085 BSB 0086 Carbonic Anhydrase/DAB CD Epsilon/AEC CKBE/Alk Blue

PolyDetector Technology IHC PolyDetector Detection Systems The Bio SB PolyDetector is a non-biotin, micro-polymeric detection system that allows for the

The Bio SB PolyDetector was developed with proprietary tandem hyperlabelling micro-polymer technology used to directly label immunoglobulins with enzymes.

The increased sensitivity of the PolyDetector system allows for rapid staining procedures without compromising stain quality.

PolyDetector HRP/AP Overview Anti-mouse and rabbit Fab micro-polymer detection technology allows for better cell penetration to deliver a highly specific and

AP and HRP Systems can be used in multiplex IHC staining. Optimized for use with Bio SB Tinto Prediluted antibodies. Kits available in mouse/rabbit configurations.

Antigen Substrate Chromogen AP/HRP Micro-polymer Primary Antibody Peroxidase Block Recommended DAB Protocol Above: Bio SB PolyDetector mechanism of action.

4 PolyDetector Technology IHC PolyDetector Detection Systems The Bio SB PolyDetector is a non-biotin, micro-polymeric detection system that allows for the demonstration of antigens in formalin-fixed paraffin-embedded tissue, cryostat sections, blood smears, cytosmears, and cell preparations. The Bio SB PolyDetector was developed with proprietary tandem hyperlabelling micro-polymer technology used to directly label immunoglobulins with enzymes. This ensures consistent and reproducible immunostaining for all types of nuclear, cytoplasmic and membranous antigens, in different types of tissues. The increased sensitivity of the PolyDetector system allows for rapid staining procedures without compromising stain quality. Available in HRP and AP configurations, the PolyDetector is ideal for users with a need to implement multiplex IHC technologies into their laboratories. PolyDetector HRP/AP Overview Anti-mouse and rabbit Fab micro-polymer detection technology allows for better cell penetration to deliver a highly specific and sensitive signal. Available in HRP or AP configurations. Universal Ready-to-use formulation detects mouse or rabbit antibodies. AP and HRP Systems can be used in multiplex IHC staining. Optimized for use with Bio SB Tinto Prediluted antibodies. Kits available in mouse/rabbit configurations. All kits manufactured according to US FDA and ISO 85 Guidelines. Antigen Substrate Chromogen AP/HRP Micro-polymer Primary Antibody Peroxidase Block Recommended DAB Protocol Above: Bio SB PolyDetector mechanism of action. ImmunoWasher ImmunoWasher ImmunoWasher ImmunoWasher ImmunoWasher Deparaffinize Block Antibody Label DAB 5 Hematoxylin 5 min min. 0-5 min. 5-0 min. 0 seconds GLUT- RMab DAB Protocol Time 85 minutes Presentations & umes PolyDetector HRP/DAB BSB 00 BSB 00 BSB 005 BSB 007 BSB 007A PolyDetector HRP/AEC BSB 00 BSB 00 BSB 006 BSB 008 BSB 008A PolyDetector AP Kits BSB 08 BSB 08 BSB 08 BSB 085 BSB 086 Actin SM/HRP Green S-00/AEC SOX-/Alk Magenta

PolyDetector Plus HRP Technology IHC PolyDetector Detection Plus Systems HRP The Bio SB PolyDetector Plus system is a highly sensitive micro-polymeric

which ensures consistent and reproducible immunostaining in different types of tissues.

This multiple component polymer delivers a highly sensitive and specific signal in a shorter time-frame than the PolyDetector.

deliver a highly specific and sensitive signal. Universal Ready-to-use formulation detects mouse or rabbit antibodies.

All kits manufactured according to US FDA and ISO 85 Guidelines.

5 PolyDetector Plus HRP Technology IHC PolyDetector Detection Plus Systems HRP The Bio SB PolyDetector Plus system is a highly sensitive micro-polymeric detection system that allows for the demonstration of antigens in formalin-fixed paraffin-embedded tissue, cryostat sections, blood smears, cytosmears, and cell preparations. PolyDetector Plus is developed using a proprietary tandem hyperlabelling micro-polymer technology used to directly label immunoglobulins with enzymes which ensures consistent and reproducible immunostaining in different types of tissues. The PolyDetector Plus kit incorporates a linking polymer and a micro-polymer label. This multiple component polymer delivers a highly sensitive and specific signal in a shorter time-frame than the PolyDetector. PolyDetector Plus HRP Overview 5 Substrate Chromogen Anti-mouse and rabbit Fab micro-polymer detection technology allows for better cell penetration to deliver a highly specific and sensitive signal. Universal Ready-to-use formulation detects mouse or rabbit antibodies. Short incubation times for each polymer. Optimized for use with Bio SB Tinto Prediluted antibodies. Kits available in mouse/rabbit configurations. All kits manufactured according to US FDA and ISO 85 Guidelines. Antigen HRP Micro-polymer Link Primary Antibody Peroxidase Block Recommended DAB Protocol Above: Bio SB PolyDetector Plus mechanism of action. ImmunoWasher ImmunoWasher ImmunoWasher ImmunoWasher ImmunoWasher ImmunoWasher Deparaffinize Block Antibody Link Label 5 DAB 6 Hematoxylin 5 min min. 5 min. 5 min. 5-0 min. 0 seconds MSH RMab DAB Protocol Time 70 minutes Presentations & umes PolyDetector Plus HRP/DAB BSB 057 BSB 059 BSB 06 BSB 06 BSB 065 PolyDetector Plus HRP/AEC BSB 058 BSB 060 BSB 06 BSB 06 BSB 066 HER- RMab/DAB p0 RMab/DAB Ki-67/AEC S-00 Beta & AEC

IHC Detection Chromogens Systems Bio SB Chromogens Bio SB

are optimized for use in immunohistochemistry.

chromogens can be paired with either biotin or

Multiplex IHC users can pair Bio SB AP & HRP PolyDetector

substrate-chromogens to detect multiple antigens on a

HRP Chromogens AP Chromogens Alk Blue DAB component

007 BSB 006 BSB 008 BSB 0065 BSB 008B BSB 0066 HER- Alk Red

BSB 00 BSB 0070 BSB 006 BSB 007 ER HRP Green Alk Magenta

BSB 08 BSB 0077 BSB 09 BSB 0078 BSB 00 BSB 0079 BSB 0 BSB

6 IHC Detection Chromogens Systems Bio SB Chromogens Bio SB substrate-chromogens are highly sensitive chromogens that are optimized for use in immunohistochemistry. Ideal for both clinical and research settings, Bio SB chromogens can be paired with either biotin or micro-polymer based detection systems. Multiplex IHC users can pair Bio SB AP & HRP PolyDetector systems with any combination of AP & HRP substrate-chromogens to detect multiple antigens on a tissue. HRP Chromogens AP Chromogens Alk Blue DAB component chromogen EGFR Phospho BSB 005 BSB 006 BSB 006 BSB 006 BSB 007 BSB 006 BSB 008 BSB 0065 BSB 008B BSB 0066 HER- Alk Red AEC MUC5AC BSB 00 BSB 0067 BSB 00 BSB 0068 BSB 00 BSB 0069 BSB 00 BSB 0070 BSB 006 BSB 007 ER HRP Green Alk Magenta component chromogen component chromogen Actin S.M. BSB 08 BSB 0077 BSB 09 BSB 0078 BSB 00 BSB 0079 BSB 0 BSB 0080 BSB 0 BSB 008 Chromogranin A HRP Black component chromogen CK BE MM000, Rev. A, DCN: 906, 05//05 Alk Brown BSB 0087 BSB 007 BSB 0088 BSB 007 BSB 0089 BSB 007 BSB 0090A BSB 0075 BSB 0090C BSB 0076 INI-

immunohistochemistry detection systems

immunohistochemistry detection systems ImmunoDetector PolyDetector PolyDetector Plus A wide array of highly sensitive Biotin & Fab Micropolymer based detection systems. For use in clinical and research