Product: Isosorbide dehydration p-toluene Sulphonic Acid + 2 H 2 O Sorbitol Isosorbide Name Empirical Formula Mol. Weight Sorbitol C 6 H 14 O 6 182 Liquid Isosorbide C 6 H 10 O 4 146 Solid Water 2H 2 O 36 Liquid Product: Isosorbide Flow Diagram 2.5 kg Sorbitol 70% solution 1.08 kg Isosorbide 0.02 kg p-toluene Sulphonic Acid Dehydration Distillation 1.1 kg water to ETP 0.01 kg Sodium acetate anhydrous 0.35 kg distillation residue to CHWTSDF 5000 L SS, 170-220 C 1.08 kg Isosorbide Washing 1 kg Isosorbide (Product) 0.05 litres Methanol Centrifuging 0.12 kg ML to ETP 48 SS Centrifuge Equipment Washing: 2 litres per kg
Production capacity: 5 MT/month Waste Type Quantity/kg Quantity in KL Quantity in Treatment per month KL per day Effluent Liquid 3.22 kg 16.1 0.536 To ETP Distillation Residue Solid 0.35 kg 1.75 0.058 To CHWTSDF Gaseous emissions Water vapour 0.10 kg 0.5 0.017 To atmosphere Equipment and Utilities: 1. 5000 L SS Distillation Unit 2. Thermopack: 250000 kcal/hr 3. 48 SS Centrifuge
Product: Diluted Isosorbide Dinitrate dehydration p-toluene Sulphonic Acid + 2 H 2 O Sorbitol Isosorbide 2HNO 3 H 2 SO 4 Diluted Isosorbide Dinitrate Lactose Blending + 2 H 2 O Isosorbide Dinitrate Name Empirical Formula Mol. Weight Sorbitol C 6 H 14 O 6 182 Liquid Isosorbide C 6 H 10 O 4 146 Solid Nitric Acid HNO 3 63 Liquid Sulphuric Acid H 2 SO 4 98 Liquid Isosorbide Dinitrate C 6 H 8 N 2 O 8 236 Solid
Product: Diluted Isosorbide Dinitrate Flow Diagram (Pure Product- 6 MT/M) 2.5 kg Sorbitol 70% solution 1.08 kg Isosorbide 0.02 kg p-toluene Sulphonic Acid Dehydration Distillation 1.1 kg water to ETP 0.01 kg Sodium acetate anhydrous 0.35 kg distillation residue to CHWTSDF 5000 L SS, 170-220 C 1.08 kg Isosorbide Washing 1 kg Isosorbide 0.05 litres Methanol Centrifuging 0.12 kg ML to ETP 48 SS Centrifuge 1 kg Isosorbide 0.1 kg vapor loss to scrubber 2 kg HNO 3 70% + 0.25 kg HNO 3 98% Nitration 4 kg Sulphuric Acid Reaction Mass 800 L SS, 5-15 C Precipitation 36.05 kg Sulphuric Acid + 30 litres water Washing & Unreacted isosorbide and Su Nitric Acid + drying Water to ETP 2500 L SS, 10-15 C 1.1 kg ISDN Crude 1 kg ISDN pure 0.66 kg Acetone Purification & Drying 10.76 kg Effluent to ETP 10 litres water 2500 L SS, Ambient, 50 C ISDN pure Lactose Pulverizing Blending Diluted Isosorbide Dinitrate SS Pulverizer and Mixer Equipment washings: 10 litres per kg of product
Production capacity: 15 MT/month of Diluted Isosorbide Dinitrate (6 MT/M Pure Product) Waste Type Quantity/kg Quantity in KL Quantity in Treatment per month KL per day Effluent Liquid 58.03 kg 348.18 11.60 To ETP (15% TDS) Distillation Residue Solid 0.35 kg 2.1 0.07 To CHWTSDF Gaseous emissions Water vapour + reaction vapours 0.10 kg 0.6 0.02 To scrubber Equipment and Utilities: 1. 5000 L SS Distillation Unit 2. Thermopack: 250000 kcal/hr 3. 48 SS Centrifuge 4. 800 L SS Reactor 5. 10 TR Chiller (Glycol) 6. 2500 L SS Reactor 7. SS Dryer 8. SS Pulverizer 9. SS Mixer 10. Steam boiler: 200 kg/hr 11. Nutch filter
Product: Diluted Isosorbide-5-Mononitrate dehydration p-toluene Sulphonic Acid + 2 H 2 O Sorbitol Isosorbide CH 3 COONa (CH 3 CO) 2 O HNO 3 (CH 3 CO) 2 O Isosorbide-2-Acetate-5-Nitrate + CH 3 COOH + CH 3 COOH Isosorbide-2-Acetate NaOH CH 3 ONa Lactose Blending Diluted Isosorbide-5-Mononitrate Isosorbide-5-Mononitrate + CH 3 COONa
Name Empirical Formula Mol. Weight Sorbitol C 6 H 14 O 6 182 Liquid Isosorbide C 6 H 10 O 4 146 Solid Acetic Anhydride (CH 3 CO) 2 O 102 Liquid Isosorbide-2-Acetate C 8 H 12 O 5 188 Soid Acetic Acid CH 3 COOH 60 Liquid Nitric Acid HNO 3 63 Liquid Isosorbide-2-Acetate- C 8 H 11 O 7 N 233 Solid 5-Nitrate Sodium Hydroxide NaOH 40 Solid Sodium Methoxide CH 3 ONa 54 Solid Sodium Acetate CH 3 COONa 82 Solid Isosorbide-5- Mononitrate C 6 H 9 O 6 N 191 Solid Product: Diluted Isosorbide-5-Mononitrate Flow Diagram 3.25 kg Sorbitol 70% solution 1.4 kg Isosorbide 0.026 kg p-toluene Sulphonic Acid Dehydration Distillation 1.42 kg water to ETP 0.013 kg Sodium acetate anhydrous 0.469 kg distillation residue to CHWTSDF 2500 L SS, 170-220 C 1.4 kg Isosorbide Washing 1.29 kg Isosorbide 0.05 litres Methanol Centrifuging 0.15 kg ML to ETP 48 SS Centrifuge 1.29 kg Isosorbide 1.29 kg Isosorbide-2-Acetate 0.95 kg Acetic Anhydride Acetylation Distillation 0.26 kg Acetic Acid (by-product) to sale 0.086 kg Sodium acetate anhydrous 0.77 kg distillation residue to CHWTSDF 2500 L SS, 100-170 C
1.29 kg Isosorbide-2-Acet 1500 L SS, 5-15 C 0.2 kg vapor loss to scrubber 1.43 kg Acetic Anhydride Nitration 0.57 kg Nitric Acid 98% 3.09 kg Reaction Mass 8.18 kg Effluent to ETP Extraction 0.45 kg Methylene Chloride + 4.9 kg recycled MeCL 2 0.04 kg Spent charcoal to CHWTSDF 3000 L SS, 10 C 7.1 litres water + 0.04 kg charcoal 7.36 kg Reaction mass MeCl 2 Extract Distillation 2000 L SS 40-50 C, 8 hrs 4.9 kg MeCl 2 (reuse) 2.01 kg Reaction Mass & 0.45 MeCl2 loss to scrubber Distillation 2000 L SS 2.23 kg Methanol (reuse for 10 batches ) 2.4 kg Methanol + 0.04 kg Charcoal 50-60 C,8Hrs 0.04 kg Spent Charcoal to CHWTSDF 0.035 kg Sodium Methoxide 1.75 kg Reaction Mass + 0.465 kg to scrubber 12.1 kg Toluene (reuse) + 0.2 kg losses Extraction 0.15 kg Reaction 12.3 kg Toluene 2500 L SS 70 C, 3 hr Waste 1.6 kg ISMN Crude 2.4 kg Water Recrystallization Drying SS Crystallizer, SS Centrifuge, SS Dryer, SS Pulverizer, SS Mixer 2.2 kg Water to ETP 1 kg ISMN 0.8 kg evaporation loss to scrubber Diluted Isosorbide-5-Mononitrate Lactose Blending Equipment washings: 25 litres per kg of product
Production capacity: 13 MT/month of Pure Isosorbide Mononitrate Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid 36.95 kg 480.35 16.01 To ETP Distillation Residue Solid 1.239 kg 16.1 0.536 To CHWTSDF Solid Hazardous Solid 0.15 kg 1.95 MT 0.065 To CHWTSDF Waste Gaseous emissions Water vapour 1.315 kg 17 0.569 To scrubber + Solvents + reaction vapours By products Acetic Acid 0.26 3.38 0.1126 Sale to authorized dealer Equipment and Utilities: 1. 5000 L SS Distillation Unit 2. Thermopack: 250000 kcal/hr 3. 48 SS Centrifuge 4. 2500 L SS Distillation Unit 5. 1500 L SS Reactor 6. 10 TR Chilling Unit (Glycol) 7. 3000 L SS Reactor 8. 2000 L SS Distillation Unit 9. 2500 L SS Distillation Unit 10. 1000 L SS Reactor 11. SS Crystallizer 12. 36 SS Centrifuge 13. SS Dryer 14. SS Pulverizer 15. SS Mixer 16. Sparkler filter/nutch filter 17. Steam boiler: 400 kg/hr
Product: Dimethyl Isosorbide dehydration p-toluene Sulphonic Acid + 2 H 2 O Sorbitol Isosorbide 2NaOH (CH 3 ) 2 SO 4 Dimethyl Isosorbide + Na 2 SO 4 + 2 H 2 O Name Empirical Formula Mol. Weight Sorbitol C 6 H 14 O 6 182 Liquid Isosorbide C 6 H 10 O 4 146 Solid Dimethyl Sulphate (CH 3 ) 2 SO 4 126 Liquid Sodium Hydroxide NaOH 40 Solid Dimethyl Isosorbide C 8 H 14 O 4 174 Liquid Sodium Sulphate Na 2 SO 4 142 Solid
Product: Dimethyl Isosorbide Flow Diagram 2.5 kg Sorbitol 70% solution 1.08 kg Isosorbide 0.02 kg p-toluene Sulphonic Acid Dehydration Distillation 1.1 kg water to ETP 0.01 kg Sodium acetate anhydrous 0.35 kg distillation residue to CHWTSDF 5000 L SS, 170-220 C 1.08 kg Isosorbide Washing 1 kg Isosorbide 0.05 litres Methanol Centrifuging 0.12 kg ML to ETP 48 SS Centrifuge 1 kg Isosorbide 0.1 kg losses to scrubber 1.26 kg Sodium Hydroxide Methylation 3 kg Dimethyl Sulphate 2500 L SS 2.05 kg water 70 C (ETR) Reaction Mixture 6 kg water 3.6 kg Methylene Chloride Extraction 2500 L SS, 25-30 C 12.11 kg ML to ETP 4.7 kg Extract in MeCl 2 Distillation 3.3 kg MeCl 2 for reuse + 0.3 losses to scrubber 2500 L SS 40-50 C 10 hrs 1.1 kg Crude Dimethyl Isosorbide High Vacuum Distillation 1 kg Dimethyl Isosorbide 0.1 kg Distillation Residue 1500 L SS, 120-130 C 6 hrs Equipment washings: 7 litres per 1 kg of Dimethyl Isosorbide
Production capacity: 5 MT/month of Dimethyl Isosorbide Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid 20.33 kg 101.65 3.38 To ETP Distillation Residue Solid 0.45 kg 2.25 0.075 To CHWTSDF Gaseous emissions Water vapour and reaction vapours 0.4 kg 2 0.06 To scrubber Equipment and Utilities: 1. 5000 L SS Distillation Unit 2. Thermopack: 250000 kcal/hr 3. 48 SS Centrifuge 4. 2500 L SS Distillation Unit 5. 1500 L Distillation Unit
Product: Diluted Nitroglycerin (1.5 MT Pure) HNO 3 / H 2 SO 4 + 3H 2 O 5-10ºC Glycerin Nitroglycerin Name Empirical Formula Mol. Weight Glycerin C 3 H 8 O 3 92 Liquid Nitric Acid HNO 3 63 Liquid Sulphuric Acid H 2 SO 4 98 Liquid Nitroglycerin C 3 H 5 N 3 O 9 227 Liquid Product: Diluted Nitroglycerin Flow Diagram 0.75 kg Glycerin 1 kg Nitroglycerin 1.31 kg HNO 3 70 % + 0.56 kg HNO 3 98% Nitration 0.05 kg Losses to scrubber 2.8 kg Sulphuric Acid 104.57 kg ML to ETP 100 kg Water Washing 0.2 kg CaCl 2 Diluted Nitroglycerin Blending with Lactose Equipment: 5 L Glass Reactor, 5-10 C Equipment washings: 2 litres per kg of Nitroglycerin
Production capacity: 25 MT/month of Diluted Nitroglycerin Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid 106.57 kg 159.85 5.32 To ETP Gaseous emissions Reaction vapours 0.05 kg 0.075 0.0025 To scrubber Equipment and Utilities: 1. 5 L Glass Reactors 2. Chilling Unit: 5 TR (Glycol) 3. SS Mixer
Product: Carbimazole Vinyl acetate CH 3 OH, Soda ash + Br 2 + CH 3 COOCH 3 + CH 3 OH Bromoacetaldehyde Dimethyl acetal CH 3 OH CH 3 NH 2 KOH + CH 3 OH (Methylamino)acetaldehyde Dimethyl acetal Acetone NH 4 SCN Mercazole (Methimazole) Pyridine ClCOOC 2 H 5 Acetone Carbimazole
Name Empirical Formula Mol. Weight Vinyl acetate monomer C 4 H 4 O 2 86 Liquid Bromine Br 2 159.8 Liquid Methanol CH 3 OH 32 Liquid Bromoacetaldehyde BrCH 2 CH(OCH 3 ) 2 169 Liquid Dimethyl Acetal (BAMA) Methyl Acetate CH 3 COOCH 3 74 Liquid Monomethyl Amine CH 3 NH 2 31 Gas (Methylamino)acetaldehyde CH 3 NHCH 2 CH(OCH 3 ) 2 119 Liquid Dimethyl Acetal (MAMA) Potassium Bromide KBr 89.9 Solid Ammonium Thiocyanate NH 4 SCN 76 Solid Mercazole (Methimazole) C 4 H 6 N 2 S 114 Solid Ethyl Chloroformate ClCOOC 2 H 5 108.5 Liquid Carbimazole C 7 H 10 N 2 O 2 S 186 Solid Pyridine C 5 H 5 N 79.1 Liquid Acetone CH 3 COCH 3 58 Liquid
Product: Carbimazole Flow Diagram 6.64 kg Vinyl Acetate Monomer 5.64 kg BAMA 12.5 kg Bromine Bromination 3 kg Methyl acetate 12.1 kg Methanol 8 kg Methanol recycle 2.14 kg Soda Ash 81.14 kg Aqueous Effluent to ETP 71.4 kg Water 7 kg Sodium Bromide to ETP 5.64 kg BAMA 1.975 kg MAMA 10.78 kg MMA 40% solution 10.23 kg Methanol recycle 6.32 kg Methanol Amination 25.83 kg Effluent to ETP 8.3 kg KOH 3 kg Potassium Bromide to ETP 10 kg water 1.975 kg MAMA 0.98 kg Mercazole 0.93 kg Acetone 1.18 kg Ammonium Thiocyanate Cyclization Distillate Acetone ML for product recovery 0.98 kg Mercazole 1.25 kg Carbimazole crude 1.16 kg Ethyl chloroformate 12.71 kg effluent to ETP 0.86 kg Pyridine Esterification 3.10 kg Acetone 7.86 kg Water 1.25 kg Carbimazole crude 1 kg Carbimazole 0.18 kg charcoal Spent Charcoal 0.18 kg 7.14 kg Acetone Purification Acetone ML for recovery Equipment washings: 15 litres per kg of carbimazole
Production capacity: 2.5 MT/month of Carbimazole Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid 145 kg 362.5 12 To ETP Solid Waste Spent Charcoal 0.18 0.45 0.015 To CHWTSDF Equipment and Utilities: 1. 50 L Glass Distillation Units 15 Nos. 2. Thermopack: 50000 kcal/hr 3. Chilling unit: 5 TR (Glycol) 4. 24 SS Centrifuge 5. SS Dryer 6. SS Pulverizer 7. SS Mixer
Product: Methimazole Vinyl acetate CH 3 OH, Soda ash + Br 2 + CH 3 COOCH 3 + CH 3 OH Bromoacetaldehyde Dimethyl acetal CH 3 OH CH 3 NH 2 KOH + CH 3 OH (Methylamino)acetaldehyde Dimethyl acetal Acetone NH 4 SCN Mercazole (Methimazole)
Product: Methimazole Flow Diagram 7.75 kg Vinyl Acetate Monomer 6.58 kg BAMA 14.58 kg Bromine Bromination 3.5 kg Methyl acetate 14.2 kg Methanol 9.33 kgmethanol recycle 2.5 kg Soda Ash 94.7 kg Aqueous Effluent to ETP 83 kg Water 7.92 kg Sodium Bromide 6.58 kg BAMA 2.30 kg MAMA 12.58 kg MMA 40% solution 11.93 kg Methanol recycle Amination 7.375 kg Methanol 28.46 kg Water to ETP 9.67 kg KOH 3.51 kg Potassium Bromide 10 kg Water 2.30 kg MAMA 1.15 kg Methimazole crude 1.08 kg Acetone 1.38 kg Ammonium Thiocyanate Cyclization Distillate Acetone ML for product recovery 1.15 kg Methimazole crude 1 kg Methimazole 0.21 kg charcoal Spent Charcoal 4.6 kg Acetone Purification Acetone ML for recovery Equipment washings: 15 litres per kg of methimazole
Production capacity: 2.5 MT/month of Methimazole Waste Type Quantity/kg Quantity in MT Quantity in Treatment per month MT per day Effluent Liquid 124.59 kg 311.4 10.38 To ETP Solid Waste Spent Charcoal 0.2 0.5 0.016 To CHWTSDF Equipment and Utilities: 8. 50 L Glass Distillation Units 12 Nos. 9. Thermopack: 50000 kcal/hr 10. Chilling unit: 5 TR (Glycol) 11. 24 SS Centrifuge 12. SS Dryer 13. SS Pulverizer 14. SS Mixer
Other utilities: 1. Cooling towers: 100 TR x 1, 150 TR x 1, 50 TR x 1 2. Process Scrubbers As and where required 3. RO Water Systems: 2 x 2000 litres/hour 4. Air Handling Units (with temperature and humidity control): Section-wise for each production block 5. Generator(s) 6. Backup chilling system: 10 TR (Glycol) 7. Fire fighting system with main pump, booster pumps and diesel powered backup pump Storage Tanks: 1. Underground Storage tanks for Methanol and Toluene- 2. Water tank for fire fighting system- 3. Process Water tank 4. Domestic Water tank