MLF 3000 Fill and Seal Machines for Vials and Threaded Bottles

MLF 3000 Fill and Seal Machines for Vials and Threaded Bottles

MLF Series successful concept, modern engineering Secure investment: Due to the modular structure and large processing range form 2 to 500 ml the machines are extremely flexible in application. Refined design details and the robust constructions ensure reliable performance and lasting value over many years. Secure production: Minimal downtime as well as fast and reproducible changeover result in a high efficiency. Secure processes: The latest GMP design, optional 100% in-process control with feedback to individual filling stations and absolute reproducibility of the process-critical parameters adds up to the highest possible process security. Due to the slim construction the MLF is also ideally suited for the use of Isolator technology. The mode of operation is intermittent. Containers: up to a dia. of Ø 55 mm, double index, up to a dia. of Ø 86 mm, single index. Feed of the containers is performed typically via a rotary table directly into the transport system. The containers are guided securely, precisely and gently in the horizontally revolving cell conveyor system. The transport cells can be easily changed, without tools. A semi-automatic cell changing device operating by means of stack magazines is additionally available. Filling station: MLF machines can be equipped with all popular filling systems (see page 7), the number of filling heads is variable between 2 to 8. 2

The well-known MLF series has been fundamentally redesigned to meet the latest pharmaceutical requirements. The broad practical experience we have gained over many years has been applied to produce innovative solutions that will result in an increased benefit for our customer. Precise and smooth feed of containers Gasflushing of the containers is possible during filling, after filling and during sealing. The control of all fill weights with feedback to individual filling heads is possible with the fully automatic in-process control (see page 6). All movements, including the filling nozzle motion is completely programmable and can be stored as a recipe or as a filling program - absolute reproducibility! Discharge conveyance of the containers: The transport system provides a high degree of flexibility for the outfeed positions. Container outfeed can be performed to the front, end or back of the machine. Depending of the positioning of the good container discharge, the reject station and the discharge for the semi-automatic in-process control can also be flexibly positioned. The good containers can be discharged into trays or in a conveyor for downstream processing. Transport system with outfeed variants 3

MLF 3000 IN for the processing of injection and infusion containers Rubber stopper press-in station: Stopper orienting is performed by a vibratory bowl that is easily changed for different stopper sizes. The stopper press-in station operates on the Pickand-Place principle. A rotary movement is also possible while the stopper is being seated. The lifting movements are performed via a servo drive. Due to this, movements are programmable and can be optimized for any combination of container and stopper. Oversealing station: Alignment and feed of the caps is also performed with a vibratory bowl. For oversealing, the containers are tipped out of the conveying system against a roller and rotated. This frees them from the conveying cell during rotation - resulting in no friction between the conveying cell and the container. Through the use of servo-technology size-specific optimized movement sequences can be easily programmed. Rubber stopper closure station Orienting, feed, placement and seating of rubber stoppers ( Pick-and-Place ) Oversealing station Aluminium cap placement 4

MLF 3000 TR version for the processing of threaded bottles with a screw closure Press-in station for drop inserts: Orienting and feeding of the drop inserts is performed by a vibratory bowl, which is easily changeable for different drop dispenser sizes. The press-in station operates on the Pick-and-Place principle. Lifting movements are performed via a servo drive. Due to this, movements are progammable and can be optimized for any combination of container and stopper. Placement of dropper or spout inserts ( Pick-and-Place ) Placement station for screw caps: The alignment and feed of screw caps is performed with a vibratory bowl. The screw caps are placed on the Pick-and-Place principle. Caps are placed and rotated on at the same station. Lifting movements are performed via a servo drive. Due to this, movements are programmable and can be optimized for any combination of container and screw cap. Screw-cap station: Both screw heads are driven separately by their own servo motors. The rotation and application torque is monitored. Torque peaks that occur during rotation, e.g. during the processing of tamperevident closures, can be masked out and stored in the program like the maximum torque. Final screwing tight of screw caps 5

MLF optional equipment, examples Container feed via rotary table Semi-automatic changing of the transport cells by magazine A large selection of optional equipment is available to meet special, customer-specific requirements. Container feed: The container feed is performed via a rotary table (single point or 2-point) directly into the transport system. Size cell changing device: The transport cells can be easily changed without tools using the semiautomatic changing device. The size cells are automatically stacked on stacking magazines. In-process-control (IPC): Increase in the pharmaceutical security with fully automatic 100% in-process control of the filling weights. For correct weighing on the tare and gross weighing cells the containers are freed from the transport cells by a special patented system. If trends in fill weight are detected, automatic compensation of individual filling station is possible. Containers outside of the specified filling tolerance are reject. All weights measured can be logged. Fully automatic in-process control (IPC) of the filling weights 6

Filling systems for specific applications Valid for all filling systems: Filling programs can be stored as a recipe and activated via the control panel. Fully automatic tracking of the fill volumes per filling station by the in-process control (IPC) or manually via the control panel. Drip-free filling by product-specific customization of the filling program. Designed for CIP/SIP Maximum output through size and product-specific optimization of the filling nozzle movement and pump stroke, independent of the machine cycle. Same dosing process in setup and production mode - as a result better reproducibility. 1 2 3 4 5 1) Time-pressure filling system: Minimum quantity of product contact parts. Nor wear, no abrasion. Short CIP/SIP cycle. Easy cleaning of product contact parts. Easy changeover. Closed system, well suited for wall installation or Isolator. Complete run to empty of the filling system is possible, no product residue in the system. Suitable for cold filling, the complete system can be cooled and insulated. Suitable for the filling of crystallizing or shear-sensitive products and/or suspensions. 2) Filling system with mass-flow measurement High degree of filling precision and reproducibility with direct measurement of the mass - no computation. No wear, no abrasion. Short CIP/SIP cycle time. Closed system. Insensitive to temperature fluctuations. Product temperature and density are recorded. Running to empty is possible. Suitable for filling crystallizing or shear-sensitive products. 3) Rotary slide valve piston pumps: Two versions available: stainless steel and ceramic. On the stainless steel version the pump cylinder, pistons and rotary slide valve are each made from one piece of material. Each filling head has a separate servo drive. Large processing range per pump size. Volumetric filing system, insensitive to viscosity and temperature fluctuations. Well suited for the filling of suspensions. 4) Filling system with peristaltic pumps: Minimum quantity of product contact parts. No wear, no abrasion. Closed system. Insensitive to temperature fluctuations. Good suitability for filling crystallizing or shear-sensitive products. 5) Rolling diaphragm pump filling station: Closed system. No wear, no abrasion. Insensitive to temperature fluctuations. Each filling head has a separate servo drive. Large processing range per pump size. Volumetric filling system, insensitive to viscosity and temperature fluctuations. Good suitability for filling crystallizing or shear-sensitive products. 7

Technical Data Output up to 7.200 containers/hour Containers: Vials, infusion and threaded bottles made of glass or plastic with a max. Ø 86 mm, max. height 180 mm Liquid products Closures: Liquid and lyo rubber stoppers up to Ø 32 mm in dia. Oversealing caps up to Ø 36,5 mm in dia. Drop inserts, pipettes and spray pumps Screw caps up to Ø 36 mm in dia. Installation and clean room variants: LF cover Wall installation RABS (Restricted Access Barrier System) Isolator technology The illustrations in this leaflet are application examples only! Binding data and specifications are included our individual quotation exclusively. All dimensional specifications are in mm. Subject to technical modifications. PA/MKT 05/06 1,0 E WA Iorio, 71560 Sulzbach Paper: natural white, without chlorine All rights reserved Locations world-wide Bosch Packaging Technology Headquarters Robert Bosch GmbH Packaging Technology Division Waiblingen Phone: +49 711 811-0 Fax: +49 711 811-57 818 E-mail: pa@boschpackaging.com Brazil Sigpack Tecnologia de Embalagem Ltda. São Paulo Phone: +55 11 41 91-68 00 Fax: +55 11 41 91-61 97 E-mail: sigpackbrazil@sigpack.com www.sigpack.com.br China Bosch Packaging Technology (Hangzhou) Co.Ltd. Hangzhou Phone: +86 571 93-55 26 Fax: +86 571 88 91-30 11 E-mail: jens.mack@boschpackaging.com Denmark Moeller & Devicon A/S Sandved Phone: +45 55 46 24 00 Fax: +45 55 45 20 21 E-mail: info@m-d.dk www.m-d.dk France Bosch Techniques d Emballage S.A.S. Reichstett Phone: +33 3 88 20-98 10 Fax: +33 3 88 20-26 10 E-mail: pafr@boschpackaging.com Germany Robert Bosch GmbH Packaging Technology Division Product Division Pharma Liquid Crailsheim Phone: +49 79 51 4 02-1 Fax: +49 79 51 4 02-2 58 E-mail: pa@boschpackaging.com Great Britain Bosch Packaging Services Ltd. Derby Phone: +44 13 32 62 62 62 Fax: +44 13 32 62 62 59 E-mail: uk-hub@sigpack.com www.sigpack.com India Motor Industries Co.Ltd. Bangalore Phone: +91 80 29 9-20 33 Fax: +91 80 22 1-37 06 E-mail: vtin@in.bosch.com Japan Bosch Packaging Technology K.K. Tokyo Phone: +81 3 32 06-28 21 Fax: +81 3 32 06-28 22 E-mail: vtjp@boschpackaging.com www.bosch.co/jp/packaging Bosch Packaging Technology K.K. Chiba Phone: +81 4 74 35-25 74 Fax: +81 4 74 32-81 83 E-mail: vtjp@boschpackaging.com www.bosch.co/jp/packaging Singapore Bosch Packaging Technology (Singapore) Pte. Ltd. Singapore Phone: +65 67 46-06 00 Fax: +65 67 46-31 00 E-mail: sigpackasia@sigpack.com www.sigpack.com USA Bosch Packaging Technology Inc. Pharma Divison Minneapolis, MN Phone: +1 763 424-47 00 Fax: +1 763 424-67 11 E-mail: sales@boschpackaging.com www.boschpackaging.com