Genentech Sustainability Data and Notes

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Gnntch Sustainability Data and Nots 2009 - Prformanc Data Units 2009 2010 2011 nsit Enrgy Us 1000 GJ Stationary Combustion 1,367 1,304 1,215 1,197 Purchasd Elctricity 1,153 1,125 1,081 1,044 Total Enrgy Us 2,520 2,429 2,296 2,241 Scop 1 and 2 GHG Emissions Mtric tons Stationary Combustion 71,419 65,958 61,458 60,485 Purchasd Elctricity 108,324 99,529 92,569 89,499 Vhicl Flt 27,820 22,635 18,176 13,008 Emissions from HFC Rfrigrants 2,631 1,143 1,061 2,200 Procss Gass 1,178 1,178 1,178 1,178 Total Scop 1 and 2 GHG Emissions 211,372 190,444 174,442 166,370 Scop 3 GHG Emissions Mtric tons Businss Travl (Air) 40,841 49,900 46,658 54,458 Employ Commuting (SSF only) 32,829 25,829 23,906 25,034 Non-GHG Emissions to Air Mtric tons R-11 zon Dplting Substancs (DS) 0.06 0.04 0.12 0.03 Total Watr Us Cubic mtrs 2,577,595 2,450,582 2,393,128 2,424,859 Gnral Wast Mtric tons Landfill 3,691 3,380 2,930 2,698 Rcycling 3,490 2,783 3,197 2,706 Composting 788 753 1,030 1,772 -wast 81 272 426 316 Total Gnral Wast 8,049 7,188 7,583 7,492 Divrsion Rat (gnral wast) % 54 53 61 64 1

NTES T SUPPRT THE DATA TABLE Gnral Nots Th data prsntd in this rport ar for th following production and fill/finish facilitis: South San Francisco, Vacavill and cansid, California, and Hillsboro, rgon. Th data also includ th rsarch, dvlopmnt, commrcial and administrativ offics at our South San Francisco hadquartrs and our Louisvill, Kntucky distribution facility. This rport includs data from 2009 to for all facilitis. Th annual Roch intrnal rporting timlin is in Novmbr and rquirs rporting of Jan-ct data, xtrapolatd to provid a full yar stimat. Unlss othrwis statd, th rportd data ar xtrapolatd in lin with th Roch rporting policy. This rport dos not includ prformanc data for joint vnturs or outsourcd oprations, nor dos it includ data for sals offics. No data ar shown for buildings that Gnntch lass out to othr partis. Data ar rportd for nw ownd facilitis and buildings from th point at which Gnntch bcoms rsponsibl for paymnt of utilitis and othr srvics, such as wast disposal. Data ar rportd for nw lasd buildings from th point at which th building bcoms occupid by Gnntch. All figurs in th data tabl, with th xcption of figurs lss than 20, ar roundd to th narst whol numbr. Du to this rounding, th individual lmnts of th data tabl may not always add up to th totals. All lctricity, natural gas and watr data ar basd on mtr radings providd by our utility vndors. nsit Enrgy Us Th 2009 and 2010 onsit nrgy us data wr xtrnally auditd in Dcmbr 2010 by PricwatrhousCooprs as part of th annual Roch Group sustainability data vrification procss. Grnhous Gas Emissions (Gnral) Th grnhous gass includd in th rportd data ar carbon dioxid, mthan, nitrous oxid and hydrofluorocarbons. Th GHG missions data ar rportd as quivalnts ( ). Small mission sourcs (i.. thos accounting for <1% of th total missions) ar hld flat from 2009. Grnhous Gas Emissions from Enrgy Us 2009 rportd data ar basd on full yar prformanc. 2010 - data combin th xtrapolatd ful us data rportd to Roch Group with th mission factors shown in th tabls blow. Elctricity-Rlatd Emission Factors South San Francisco, Vacavill and cansid, California 2009 0.72412 lb 0.0302 lb CH 4 0.0081 lb 2010 0.681 lb 0.0208 lb CH 4 0.006 lb 2011-0.658 lb /kwh U.S. EPA GRID v1.1 Rgional mission factors for 0.0289 lb CH 4 0.006 lb Louisvill, Kntucky 2009 1.509 lb 0.0201 lb CH 4 0.0256 lb 2010 1.541 lb 0.02 lb CH 4 0.026 lb 2011-1.357 lb /kwh U.S. EPA GRID v1.1 Rgional mission factors for 0.0173 lb CH 4 0.022 lb Hillsboro, rgon 2009 0.902 lb 0.0191 lb CH 4 0.0149 lb 2010 0.859 lb 0.016 lb CH 4 0.014 lb 2011-0.819 lb /kwh U.S. EPA GRID v1.1 Rgional mission factors for 0.015 lb CH 4 0.0125 lb 2

Natural Gas-Rlatd Emission Factors All Sits 2011 5.306 kg 0.5 g CH 4 0.01 g 5.302 kg 0.10 g CH 4 0.01 g U.S. EPA Climat Ladrs Stationary Combustion Protocol (May 2008) Fdral Rgistr (2009) EPA; 40 CFR Part 98 t al; Mandatory Rporting of Grnhous Gass; Final Rul, 30ct09, Tabls C-1 and C-2, pp. 54609-54610. Disl-Rlatd Emission Factors All Sits 2010 10.15 kg 0.0014 kg CH 4 0.0001 kg 2011-10.21 kg 0.00041 kg CH 4 0.00008 kg U.S. EPA Climat Ladrs Stationary Combustion Protocol (May 2008) Fdral Rgistr (2009) EPA; 40 CFR Part 98 t al; Mandatory Rporting of Grnhous Gass; Final Rul, 30ct09, Tabls C-1 and C-2, pp. 54609-54610. Global Warming Potntials (GWP) Usd to Calculat Gas Nam GWP Sourc C 1 2 Intrgovrnmntal Panl on Climat Chang (IPCC) CH 21 4 (1995); Scond Assssmnt 310 Rport. Grnhous Gas Emissions from Vhicl Flt This catgory compriss missions from th Gnntch commrcial flt and on-sit vhicls. Th commrcial flt rprsnts 95% of th total vhicl flt missions. Emissions from non-sals road businss travl by mploys (a scop 3 mission sourc) hav not bn includd in th rportd data. Th commrcial flt includs both mploy-ownd vhicls and vhicls lasd by Gnntch. In th cas of mploy-ownd vhicls, flt milag is calculatd from mploy xpns claims, and gallons ar calculatd using an avrag ful conomy. Th avrag ful conomy valu usd for 2009 was takn from th Enrgy Information Administration s annual Transportation Enrgy Yar Book. For 2010-, avrag mpg valus wr obtaind from annual mploy survys. In th cas of lasd vhicls and onsit vhicls, actual ful us data is trackd in and xtractd from a propritary databas. As part of th intgration of Gnntch with Roch, th ntir US commrcial organization and associatd vhicl flt transitiond to Gnntch SSF s rsponsibility arly in 2010. Th vhicl missions arising from th ntir US commrcial organization hav bn includd in th 2009-2011 data prsntd in th Data Tabl in ordr to align with th baslin for th Roch Group nrgy goal. Vhicl Flt Emission Factors (Gasolin) GHG Yar Emission Factor Sourc 2010 2011- CH 4 8.81 kg US EPA (2008); GHG Invntory Protocol Cor Modul Guidanc - Dirct Emissions from Mobil Combustion Sourcs, EPA Climat Ladrs, Tabl 5. 8.78 kg Fdral Rgistr (2009) EPA; 40 CFR Part 98 t al; Mandatory Rporting of Grnhous Gass; Final Rul, 30ct09, Tabls C-1 and C-2, pp. 54609-54610. 0.0051 g/mil US EPA (2011) Invntory of U.S. GHG Emissions and Sinks: 1990-2009, EPA 430-R-11-005. All Valus ar calculatd from Tabls A-97 through A-100. Basd on 0.0168 g/mil an assumd SUV: passngr car mix. Vhicl Flt Emission Factors (Disl) GHG Yar Emission Factor Sourc 2010 2011- CH 4 10.15 kg US EPA (2008); GHG Invntory Protocol Cor Modul Guidanc - Dirct Emissions from Mobil Combustion Sourcs, EPA Climat Ladrs, Tabl 5 10.21 kg Fdral Rgistr (2009) EPA; 40 CFR Part 98 t al; Mandatory Rporting of Grnhous Gass; Final Rul, 30ct09, Tabls C-1 and C-2, pp. 54609-54610. 0.0015 g/mil U.S. EPA Emission Factors for GHG Invntoris (Novmbr 2011) Emission factor for 1996-prsnt for advancd 0.001 g/mil light trucks. Global Warming Potntials (GWP) for mthan and nitrous oxid ar as shown in th Grnhous Gas Emissions from Enrgy Us sction abov. 3

Grnhous Gas Emissions from HFC Gass This catgory includs missions from stationary air conditioning, cooling and fir supprssion quipmnt. For 2009 1 -, th rportd data ar basd on lak rports gnratd during srvicing and maintnanc. Full yar data ar rportd for 2009. Th tabl blow shows th HFC gass includd in th missions calculations, and thir GWPs. Gas Nam GWP Sourc R-134a 1,300 R-404A 3,260 R-410A 1,725 R-507 3,300 ISCEN M89 3,038 R508B 10.530 R23 11,700 R407C 1,526 Grnhous Gas Emissions from Procss Gass U.S. EPA Climat Ladrs Dirct HFC and PFC Emissions from Us of Rfrigration and Air Conditioning Equipmnt missions from dry ic and liquid and gas, wr stimatd in 2008 using purchas data from vndors. In th absnc of standard calculation mthods, Gnntch assums that 100% of th usd for ths purposs is vntd to th atmosphr. As ths gass ar a small sourc, th 2008 missions hav bn hld flat for 2009. GHG missions from Gnntch s us of CH 4 and in manufacturing and rsarch and dvlopmnt wr also calculatd in 2008 using vndor purchas data and US EPA Climat Ladrs mission factors. Emissions ar rportd as quivalnts and hav bn hld flat for as thy ar also a small sourc. Grnhous Gas Emissions from Businss Travl (Air) Air travl includs th us of commrcial aircraft for th purpos of businss travl. Gnntch dos not own, oprat or chartr privat aircraft. Th air travl data prsnt missions arising from flights mad by Gnntch mploys, which wr bookd through Gnntch s official travl agncis. Travl bookd through altrnativ mans is not includd. Full yar data ar rportd for. As part of th intgration of Gnntch with Roch, th ntir U.S. commrcial organization transitiond to Gnntch SSF s rsponsibility arly in 2010. Th air travl missions arising from th ntir U.S. commrcial organization hav bn includd in th data prsntd in th Data Tabl in ordr to align with th baslin for th Roch Group nrgy goal. Th raw data w rcivd on air travl mils for 2008-2010 hav bn brokn down into short, mdium, and long haul flights. GWPs for mthan and nitrous oxid ar as shown in th Enrgy Us sction abov. 2009 and 2010 grnhous gas missions wr calculatd using mission factors from th DEFRA GHG Convrsion Factor Guidlins. In lin with this guidanc, all mission factors blow ar combind with a 109% uplift factor in ordr to stimat total GHG missions. All mission factors ar for coach class travl. Air Travl Emission Factors, 2009 Flight Typ/Gas Emission Factor Sourc Short Haul (<300 mils) from CH 4 0.171 kg/km 0.00013 kg/km 0.00168 kg/km Mdium Haul (300-2,300 mils) from CH 4 Long Haul (>2,300 mils) from CH 4 0.0098 kg/km 0.00001 kg/km 0.00097 kg/km 0.112 kg/km 0.00001 kg/km 0.0011 kg/km Th 2010 mission factors ar th sam as for 2007-2009 with th following xcptions. Air Travl Emission Factors, 2010 Flight Typ/Gas Emission Factor Sourc Short Haul (<300 mils) 0.175 kg/km 2010 Guidlins to DEFRA 0.00169 kg/km Mdium Haul (300-2,300 mils) 0.0097 kg/km 2010 Guidlins to DEFRA 0.00095 kg/km Long Haul (>2,300 mils) 0.113 kg/km 2010 Guidlins to DEFRA 2011 and grnhous gas missions wr calculatd using an mission factor of 0.071 tons / GJ, which is th mission factor usd across th Roch organization. 1 With th xcption of th South San Francisco sit which usd th sam mthod as for 2008 4

Grnhous Gas Emissions from Employ Commut Employ commuting missions stimats ar basd on th rsults of cordon counts to stablish modal split at th points of ntry to Gnntch s South San Francisco facility. Ths data ar supportd by additional information rlatd to th Gnntch shuttl flt and data availabl from third partis, such as mission factors for local public transit providrs including Bay Ara Rapid Transit (BART) and Caltrain. Th study maks svral assumptions such as th avrag distanc travld by Gnntch mploys travling alon and th composition of th Gnntch mploys vhicl flt, and som portions of multimodal commuts. Th WRI/WBSCD Employ Commut tool was usd as th sourc starting point for th missions modl convrsion factors. Th modl usd to stimat mploy commut missions is updatd and rfind as bttr data and mor dtaild information bcoms availabl. Th stimats, and whr appropriat, rcalculations of th 2011 stimats incorporat th following modl rfinmnts mad during : Updatd driv alon missions factors from th US Dpartmnt of Enrgy Transportation and Enrgy Data Book (31st Edition) Addd missions from th nw Alamda-ystr Point frry (proratd for th portion of th yar that it was oprational) Th commut distanc for all mods was rcalculatd from grid rgistration data for ctobr. Th nw GIS data indicats that th avrag commut distanc for most mods did not chang significantly from 2011. Updatd GnnBus missions basd on B20 ful consumd in th prvious 12 months Non-GHG Emissions to Air zon Dplting Substancs (DS) This catgory includs missions of chlorofluorocarbons (CFCs) and hydrochlorofluorocarbon (HCFCs) gass from stationary air conditioning, cooling and fir supprssion quipmnt. Th rportd data ar takn from lak rports gnratd during srvicing and maintnanc. In accordanc with th Global Rporting Initiativ rporting guidlins, w hav rportd CFC and HCFC rlass as R11 quivalnts, using th ozon dpltion potntials blow. to rciv actual wight data from its wast vndor for th landfilld wast stram and svral of th rcycling strams. SSF stimats for 2009 and 2010 hav bn updatd basd on th avrag pr containr wight calculatd in 2011. W show rusd/rcycld lctronic wast as an individual lin itm in th Gnral Wast catgory. Includd ar lctronic itms such as computrs, monitors, kyboards, lab quipmnt, cold storag units and cll phons. Divrsion rat (%) is th total wight of rcycld and compostd wast dividd by th total wight of all wast x 100. Gas Nam DP Sourc R-11 1.0 R-12 1.0 R-22 R-123 0.055.02 R-502 0.25 http://www.pa.gov/ozon/scinc/ ods/classon.html http://www.pa.gov/ozon/scinc/ ods/classtwo.html http://www.unpti.org/ozonaction/ topics/hcfcblnds.htm Gnral Wast Gnral wast includs trash, rcyclabls, food wast and othr compostabl matrials and usd lctronic and lctrical quipmnt. Gnral wast xcluds wasts that ar managd by th Gnntch Environmntal, Halth and Safty group, du to thir rgulatd and/or hazardous natur. Bfor 2011, most catgoris of wast from th SSF facility had bn stimatd using a standard wight pr containr multiplid by th numbr of containr pick-ups during th rporting yar. In 2011 SSF bgan 5