GMP - designed Maintenance-free Diaphragm valve made of forged stainless steel according to ASME BPE and investment casting

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Jeffry Craig
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1 type series booklet /22-10 GMP - designed Maintenance-free Diaphragm valve made of forged stainless steel according to ASME BPE and investment casting with Buttweld ends or clamps PN 10 size range 1/4-4 Fields of application Biotechnology, sterile process technology, food and pharmaceutical industry. Operating data - Operating temperature range from -10 C (-22 F) up to +160 C (320 F) - Operating pressure range from vacuum up to 10 bar (145 psig) - Pneumatic actuator Sistomat P designed for 10 bar (145psiG)operating pressure (EPDM-diaphragm) - Air supply pressure LAP 5-7 bar (72,5-101,5 psig) LAD 4-6 bar (58-87 psig) Design Soft sealing valve, weir type, either manual or pneumatic actuator operated. Sealing in the seat and towards the outside by a diaphragm, no entrapment areas. Suitable for SIP and CIP. Self draining angle indicated by hash-marking on buttweld end. Actuator: SISTOMAT-P LAP-SF Air to open - Spring to close (DN 06-50) LAD-SF Air to open - Spring to close (DN 65-) Specification Valve - buttweld ends DIN Serie A (DIN 11850) DIN Serie B(DIN EN ISO 1127/ ISO 4200) DIN Serie C (OD ASME BPE) SMS 3008 JIS-G clamps DIN ASME BPE SMS 3017 JIS-G marking DIN/EN 19 (ISO 5209) ASME BPE Inspection Material certificate EN EN Final inspection EN According to American standards (ASME BPE) The SISTO valves meet the safety requirements of the Pressure Equipment Directive 97/23/EG (PED) of annex I for fluids of the groups 1 and 2, Modul H. Materials DN DN 65- DN *) size.24-2" size 2.5-4" size 4" Body (CF3M) 316L (1.4435) forged material Investment casting FE<2% according to ASME BPE: sulfure equivalent 316L content<0,017 %BN2: Fe<0,5% Bonnet 316L JL-1040/JS-1025/RN 316L Compressor 316L JL L Diaphragm EPDM(FDA) EPDM(FDA) EPDM(FDA) Screws A2-70 A2-70 A2-70 Handwheel PA6GF30 JL1030/RN JL1030/RN Actuator PA6GF30 St37/RN St37/RN *) Stainless steel version Material options Body DN06-50 Body forged material 316L (1.4435) according to ASME BPE sulphur content<0,017%, BN2 FE<0,5% Diaphragm, bonded TFM/EPDM (FDA) CFR21 Section C Diaphragm, 2pieces TFM/EPDM (FDA) CFR21 Section C Design options Body design: T-form and tank-bottom-valves on others request Body end connection:clamps, flanges and others Accessories: Limit switches, adjustable travel stop and positioner, protection against contact Internal body finish Electropolished: Ra 0,8µm, Ra 0,6µm, Ra 0,5µm, Ra 0,4µm, Ra 0,25µm Ra 30µin, Ra 25µin, Ra 20µin, Ra 15µin, Ra 10µin Option: polished Further surface finish on request. On all inquiries / orders please specify 1 -Type 6 - Fluid 2 - DN 7 - Surface quality 3 - Working pressure 8 - Diaphragm quality 4 - Air supply pressure 9 - Actuator 5 - Operating temperature 10 - Certificate

2 SISTO DN ML 32 SISTO DN ML SISTO DN ML SISTO size 1/4-3/8" SISTO size 1/2-1" SISTO size 1 1/4-2" / SISTO DN ML SISTO DN - ML 226 Stainless steel version SISTO size 2 1/2-4" SISTO size 4" Item no. Designation Material Note body 316L / investment casting (1.4435[CF3M equivalent 316L]) / forged 160 Cap PA6GF30 30% glass fiber reinforced black bonnet 316L investment casting (1.4409) bonnet JL-1040/PA grey, plastic coated steel stem stem stem.4404 kolsteriert screwed bush brass screwed bush GZ-RG7 314 Axial bearing St ring EPDM 0-ring NBR diaphragm EPDM FDA, CFR 21 Section threaded disc threaded disc bearing disc 9S disc PTFE/graphite sliding disc.4104 on DN disc PTFE/A2 on DN disc POM compressor 316L investment casting (1.4409) compressor JL-1040 disc StA2E locking pin A4 580 cap nut upper opening indicator ABS/Luran upper opening indicator ABS/Luran adaptor PA6GF adaptor hexagon screw A2-70 DIN stud A threaded pin Cylinder head srew.4401 DIN floating nut brass square nut 9S20K hexagon nut A2 (1.4301) hexagon nut A2 (1.4301) on DN 923 bearing nut retaining ring A2 DIN Parallel key St spiral spring support St2K BK on DN spiral spring support.4301 on DN handwheel PA6GF30 30% glass fiber reinforced black handwheel JL1030/PA coated black, plastic coated steel

3 * * * * 412.1* 443.1* * * * / * 951 SISTO LAP-SF DN SISTO LAP-SF DN SISTO LAD SF DN 65- SISTO size 1/4-3/8" SISTO size 1/2-2" SISTO size 2 1/2-4" Air supply pressure: 5-7 bar (72,5-101,5psiG) Air supply pressure: 5-7 bar (72,5-101,5psiG) Air supply pressure: 4-6 bar (58-87psiG) Item no. Designation Material Note body 316L / investment casting / forged lower cover St37/PA coated grey, plastic coated steel upper cover St37/PA coated grey, plastic coated steel 160 screw cap PA6GF30 30% glass fiber reinforced black bonnet 316L investment casting (1.4409) bonnet JS-1025/PA coated grey, plastic coated steel 176 bottom plate PA6GF30 30% glass fiber reinforced black 200 stem thrust stem piston rod * O-ring FPM/FKM O-ring Perbunan O-ring EPDM 412.4* sealing ring NBR 443.1* diaphragm EPDM FDA, CFR 21 Section * actuator diaphragm NBR guide bush guide bush SoMs bearing disc St37 galvanised compressor 316L investment casting compressor JL-1040 disc A2 locking pin A4 DIN EN spring guide St37 galvanised 595* piston St/NBR 621 opening indicator adaptor hexagon screw A2-70 (1.4303) DIN screw 8.8A2E 902 stud A2-70 on DN 911 air connection brass for PA-tube 8 x air rent screw 9S20K 915 floating nut brass hexagon nut A2 (1.4301) hexagon nut A2 (1.4301) on DN hexagon nut 17H A2E galvanised hexagon nut 04 A2E galvanised 932 retaining ring spring steel DIN spring spring spring steel spiral spring support St2K BK on DN spiral spring support.4301 on DN 685 protection against contact plastic transparent optional *recommended spare parts

4 4 G L 2 * Actuator requires valve stroke dimension vertical clearence. Investment casted body with buttweld end Face-to-face DIN Serie A ISO 4200 OD ASME BPE SMS 3008 JIS-G 3447 Height Height DN NPS ML L1 ODxs ODxs ODxs ODxs ODxs H1 H2 d D1 6 1/4 72 8x1 ** 10,2x1,6 ** 6,35x0,89 ** 8 5/ x1 ** 13,5x1,6 ML / x1,5 9,53x0,89 ** 15 1/2 12,7x1, /8 17,2x1,6 15 1/2 ML x1,5 21,3x1,6 20 3/4 19,05x1,65 Actuator Valve stroke /4 ML ,9x1, / x1,5 ML x1,5 33,7x2 25,4x1,65 25x1,2 25,4x1, /4 ML ,4x / x1,5 33,7x1,2 ** 31,8x1,2 ** /2 ML x1,5 38,1x1,65 38x1,2 38,1x1, / ,3x ML x1,5 60,3x2 50,8x1,65 51x1,2 50,8x1, Investment casted body with clamp DIN32676 DIN Serie A OD ASME BPE SMS 3008 JIS-G 3447 Handwheel Faceto- face DN NPS ML Di Da L2 Di Da L2 Di Da L2 Di Da H1 H2 d D1 6 1/4 63,5 6 ** 25,2 * 63,5 4,57 ** 25,2 * 8 5/16 63,5 8 ** 25,2 * ML /8 63, ,2 * 63,5 7,75 ** 25,2 * 15 1/2 63,5 9,4 25,2 * 15 1/ ,2 * ML / ,75 25,2 * 20 3/ ML , ,1 50, ,6 50, , / , ,3 ** 50, ,4 ** 50,5 ML / , ,8 50, ,6 50, ,7 50,5 Height Height Handwheel Actuator Valve stroke ML , , , all dimensions in mm, unless otherwise noted * Clamp not according to DIN32676 ** self-draining on request Buttweld end length min. 20mm ISO clamp and additional executions on request

5 5 Forged body with buttweld end Face-to-face DIN Serie A ISO 4200 OD ASME BPE SMS 3008 JIS-G 3447 Heigth Heigth DN NPS ML L1 ODxs ODxs ODxs ODxs ODxs H1 H2 d D1 6 1/4 ML x1 10,2x1,6 6,35x0,89 Actuator Valve stroke 8 5/16 ML x1 13,5x1,6 10 3/8 ML x1,5 9,53x0, /2 ML ,7x1, /8 ML ,2x1,6 9,53x0, /2 ML x1,5 21,3x1,6 12,7x1, /4 ML x1,5 19,05x1, /8 ML x1,5 17,2x1,6 9,53x0, /2 ML x1,5 21,3x1,6 12,7x1, /4 ML ,05x1, /4 ML x1,5 26,9x1,6 19,05x1, /2 ML x1,5 21,3x1,6 12,7x1, /4 ML x1,5 26,9x1,6 19,05x1, ML x1,5 33,7x2 25,4x1,65 25x1,2 25,4x1, /4 ML x1,5 42,4x2 33,7x1,2 31,8x1, /4 ML x1,5 42,4x2 33,7x1,2 31,8x1, /2 ML x1,5 48,3x2 38,1x1,65 38x1,2 38,1x1, ML x1,5 60,3x2 50,8x1,65 51x1,2 50,8x1, /2 ML x2 76,1x2 63,5x1,65 63,5x1,6 63,5x /2 ML x2 76,1x2 63,5x1,65 63,5x1,6 63,5x ML x2 88,9x2,3 76,2x1,65 76,1x1,6 76,3x2 4 ML x2 114,3x2,3 101,6x2,11 101,6x2 101,6x Forged body with clamp DIN32676 DIN Serie A ISO 4200 OD ASME BPE SMS 3008 JIS-G 3447 Handwheel Face-toface Face-toface Face-toface Higth Higth Handwheeator Actu- Valve stroke DN NPS ML L2 Di Da L2 Di Da L2 Di Da L2 Di Da L2 Di Da H1 H2 d D1 6 1/4 ML32 63,5 6 25,2 * 63,5 7 25,2 * 63,5 4,57 25,2 * 8 5/16 ML32 63,5 8 25,2 * 63,5 10,3 25,2 * 10 3/8 ML32 63, ,2 * 63,5 7,75 25,2 * 15 1/2 ML32 63,5 9,4 25,2 * 10 3/8 ML ,2 * 89 7,75 25,2 * 15 1/2 ML ,2 * ,1 50,5 */** 89 9,4 25,2 * 20 3/4 ML ** ,75 25,2 * 10 3/8 ML ,2 * ,2 * 89 7,75 25,2 * 15 1/2 ML ,2 * ,1 50,5 * 89 9,4 25,2 * 20 3/4 ML ,75 25,2 * /4 ML ** ,7 50,5 */** ,75 25,2 * /2 ML ,2 * ,1 50,5 * 102 9,4 25,2 * 20 3/4 ML ,7 50,5 * ,75 25,2 * 25 1 ML , ,7 50, ,1 50, ,6 50, , /4 ML , ,4 50, ,3 50, ,4 50, /4 ML , ,4 50, ,3 50, ,4 50, /2 ML , ,3 64 */** ,8 50, ,6 50, ,7 50, ML , ,3 77,5 */** , , , /2 ML ** ,1 91 ** ,2 77,5 */** ,3 77,5 */** ,5 77,5 */** /2 ML ** ,1 91 ** ,2 77,5 */** ,3 77,5 */** ,5 77,5 */** 80 3 ML ** ,3 106 ** ,9 91 ** ,9 91 */** ,3 91 */** ML ** ,7 130 */** , ** ,6 119 ** ,6 119 ** all dimensions in mm, unless otherwise noted * Clamp not according to DIN32676 ** Clamp welded Buttweld end length min. 20mm additional executions on request

6 SISTO Bestellschlüssel / SISTO How to Order SISTO Bestellschlüssel/ 2.4 SISTO How to Order A B C D E F G H I Ventilgehäuse / Valve body Gehäusewerkstoff / Body material Nennweite DN1 / Valve size DN1 Membranlänge / Diaphragm length Anschluss / Valve end connection Membranwerkstoff / Diaphragm material Oberteil / Bonnet Oberflächenqualität / Surface finish Nennweite DN2 / Size DN2 Ventilgehäuse (SH) / Valve body (SH) A B C D E H I B 00 SH ML032 W1 E Membrane (SD) / Diaphragm (SD) C D F B SD 010 ML A B C D G B00 SB ML032 A1 Bestellbeispiel / How to order A B C D E F G H I B M L W A 1 E A B00 B01 B07 B08 B03 B06 B Ventilgehäuse / Valve body SISTO 2/2-Wege Ventilgehäuse SISTO 2-way valve body SISTOT T-Ventilgehäuse SISTOT Zero static T-valve body SISTOAS GMP/SAP-Ventilkombination 1 SISTOAS GMP/SAP-valve body 1 SISTOAV GMP/SAP-Ventilkombination 1 SISTOAV GMP/SAP-valve body 1 SISTOBAV Behälterventil 1 SISTOBAV Tank bottom valve body 1 SISTOM Mehrsitzventil 1 SISTOM Multi-port valve body 1 Gehäusewerkstoff / Body material Gehäuse geschmiedet (316L) Body forged AISI 316L, ASME BPE Gehäuse Feinguss (316L) Body casting (316L) Gehäuse Sonderwerkstoff Body special material C Nennweite DN1 / Valve size DN1 006 DN 6 1/4 008 DN DN 10 3/8 015 DN 15 1/2 020 DN 20 3/4 025 DN DN DN /2 050 DN DN /2 080 DN 80 3 DN 4 1 Für Ventilgehäuse SISTOAS, SISTOAV, SISTOBAV und SISTOM sind zusätzliche Informationen erforderlich. 1 For valve bodies SISTOAS, SISTOAV, SISTOBAV and SISTOM additional information required.

7 SISTO Bestellschlüssel / SISTO How to Order 7 D Membranlänge / Diaphragm length ML032 DN 6, 8, 10, 15 1/4, 3/8, 1/2 ML046 DN 10, 15, 20 3/8, 1/2, 3/4 ML052 DN 10, 15, 20 3/8, 1/2, 3/4 ML058 DN 20 3/4 ML067 DN 15, 20, 25 1/2, 3/4, 1 ML082 DN 32 ML090 DN 32, /2 ML108 DN 50 2 ML132 DN /2 ML158 DN 65, /2, 3 ML226 DN 4 G M0 M3 M4 M5 M6 M9 A1 A2 Oberteil / Bonnet Handbetätigt, Kunststoffhandrad Manually operated, plastic handwheel Handbetätigt, Edelstahlhandrad Manually operated, stainless steel handwheel autoclavable (up to ML 226) Handbetätigt, Kunststoffhandrad, Hubbegrenzung (Richtung offen + geschlossen) Manually operated, plastic handwheel, travel stop (open+close direction) Handbetätigt, Kunststoffhandrad, Hubbegrenzung (Richtung offen) Manually operated, plastic handwheel, travel stop (open direction) Handbetätigt, Kunststoffhandrad, Hubbegrenzung (Richtung geschlossen) Manually operated, plastic handwheel, travel stop (close direction) Handbetätigt, Kunststoffhandrad, Verriegelung Manually operated, plastic handwheel, locking device Pneumatisch, Kunststoffantrieb, Feder schließend (SF) Pneumatically operated, plastic actuator, spring to close air to open (SF) Pneumatisch, Kunststoffantrieb, Feder öffnend (OF) Pneumatically operated, plastic actuator, spring to open, air to close (OF) E W0 C0 W1 C1 W2 C2 W3 C3 W5 C5 99 F Anschluss / Valve end connection DIN A (DIN 11850) Schweißenden DIN A (DIN 11850) Butt weld ends DIN A (DIN 11850) Clamps DIN (ISO 4200/ISO 1127) Schweißenden DIN (ISO 4200/ISO 1127) Butt weld ends DIN (ISO 4200) Clamps SMS 3008 Schweißenden SMS 3008 Butt weld ends SMS 3008 Clamps DIN C (OD ASME BPE) Schweißenden DIN C (OD ASME BPE) Butt weld ends DIN C (OD ASME BPE) Clamps JIS-G 3447 Schweißenden JIS-G 3447 Butt weld ends JIS-G 3447 Clamps Sonderanschluss Special pipe connection Membranwerkstoff / Diaphragm material EPDM (FDA), bis 140 C EPDM (FDA), up to 284 F TFM/EPDM kaschiert (FDA), bis 140 C (nicht ML 132, 158, 226) TFM/EPDM bonded (FDA), up to 284 F (excl. ML 132, 158, 226) TFM/EPDM 2-teilig (FDA), bis 160 C (nicht ML 32, 52) TFM/EPDM 2-piece (FDA), up to 320 F (excl. ML 32, 52) A3 A7 H I Siehe C Code C Pneumatisch, Kunststoffantrieb, Doppelt wirkend (AZ) Pneumatically operated, plastic actuator, air to open air to close (AZ) Pneumatisch, Edelstahlantrieb, Feder schließend (SF) (bis ML108) Pneumatically operated, stainless steel actuator, spring to close (up to ML 108) Oberflächenqualität / Surface finish Nennweite DN2 / Size DN2 Nennweite DN2 für T-, Mehrsitz und GMP/SAP Ventilkörper Size DN2 for T-, multi port and GMP/SAP valve bodies ASME BPE Schlüssel / ASME BPE Code P63 Ra 6,3µm / Machined 250µ-in SF0 P32 Geschliffen Ra 3,2µm / Mechanical polished 125µ-in P16 Geschliffen Ra 1,6µm / Mechanical polished 60µ-in P25 Geschliffen Ra 0,8µm / Mechanical polished 30µ-in SF3 P20 Geschliffen Ra 0,6µm / Mechanical polished 25µ-in SF2 P15 Geschliffen Ra 0,4µm / Mechanical polished 20µ-in SF1 E25 Elektropoliert Ra 0,8µm / Electropolished 30µ-in E20 Elektropoliert Ra 0,6µm / Electropolished 25µ-in SF6 E17 Elektropoliert Ra 0,5µm / Electropolished 20µ-in SF5 E15 Elektropoliert Ra 0,4µm / Electropolished 15µ-in SF4 E10 Elektropoliert Ra 0,25µmT/ Electropolished 10µ-in Die Auftragsannahme erfolgt vorbehaltlich einer Prüfung auf Realisierbarkeit durch SISTO Armaturen S.A. Order acceptance subject to technical feasibility check at SISTO Armaturen S.A.

8 SISTO DN 006- SISTO - B size 1/4-4 Compact and integrated design of actuator ensures installation under extreme room conditions Optional assembly of limit

friction reduced movements Investment casted found body, Fe<2%, with high dimensional accuracy, excellent surface finish and optimal cost Forged stainless steel

connections Air connection shown in 90 Rotation Diaphragm ensures - dimensions according to industriel standard - absolute tightness - conformity to FDA No

Examples see catalogue 8652 SISTO sterile processes SISTO Ar

8 8 SISTO DN 006- SISTO - B size 1/4-4 Compact and integrated design of actuator ensures installation under extreme room conditions Optional assembly of limit switches, adjustable travel stop and positioner Pneumatic actuator made of reinforced polyamid Actuator piston with vulcanized metal ring ensures smooth and friction reduced movements Investment casted found body, Fe<2%, with high dimensional accuracy, excellent surface finish and optimal cost Forged stainless steel body according to ASME BPE, sulphur content<0,017% and BN2 Fe<0,5%, ensures highest surface finish for sterile process and offers many variants of pipe connections Air connection shown in 90 Rotation Diaphragm ensures - dimensions according to industriel standard - absolute tightness - conformity to FDA No entrapment areas, only diaphragm and body are in contact with the medium This document is not contractual and may be amended without notice. Examples see catalogue 8652 SISTO sterile processes SISTO Armaturen S.A. Zone Industrielle 6468 Echternach (Luxembourg) Phone: (+352) Fax (+352) sisto@ksb.com Rep office in USA: AMRI, Inc Silber Road Houston, Texas P.O.Box Houston, Texas ( USA) Phone: (+1) Fax: /22-10 /

Diaphragm Valve SISTO-C. Sterile Process Engineering PN 16 DN Type Series Booklet

Diaphragm Valve SISTO-C. Sterile Process Engineering PN 16 DN Type Series Booklet Diaphragm Valve SISTO-C Sterile Process Engineering PN 16 DN 6- Type Series Booklet Legal information/copyright Type Series Booklet SISTO-C All rights reserved. The contents provided herein must neither