Exceptional Choice for Versatile and Reliable Shaking Application

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OrbiCult TM Ambient Shaker Model AS-1-NC-19 OrbiCult TM Incubator Shaker Benchtop Model ISB1-R-19-1 TM OrbiCult Shakers Exceptional Choice for Versatile and Reliable Shaking Application

100 SHAKER V.01 SPEED (RPM) : 100 TIME (MIN) : 010 SYSTEM RUNNING : 0010 Membrane Keypad Displays all information simultaneously on the screen Easy-to-use design enable to set precise parameter Audible and visible alarm, alert any undesirable situation Automatically restart after power interruption for the non-volatile program saved in the memory SmartRun TM : Imbalance Compensation Algorithm Excellent out-of-balance sensor and propriety imbalance compensation algorithm adjust the optimum rpm to ensure smooth operation without any vibration 2 TriDrive TM : Triple-Eccentric Counterbalanced Drive System Robust triple eccentric counterbalanced drive supports long service life Two types of orbit (19 mm and 25 mm) that meets different applications Brushless DC motor provides consistent and no vibration rotation Wide Speed Range: 15-575 rpm Low noise and low heat emission Installed with acceleration / deceleration circuit, to prevent spillage Connecting Alarm Contacts Located at the back of the unit to monitor speed, shaker imbalance and power recovery alarms TM AS-1 and ISB1 Laboratory Shakers

Powder Coat Easy to clean external surface coated with Isocide TM to eliminate 99.9% of surface bacteria within 24 hours of exposure Large Capacity with Slim Structure Maximum capacity of 30 Kg CO 2 Resistant Model Designed with material resistant components that adapt in CO 2 and humid environment that assures AS-1-CO 2 resistance model to have longterm worry-free operation Suitable to cells incubation application. AS-1-C series fit in Esco 170 L and 240 L CelCulture and CelMate series CO 2 incubator 3 Leveling Feet Built-in leveling feet that can be adjusted to level the unit Multiple Interchangeable Platform Customize according to your application Application List Cell Culture Solubility Extraction Procedures Diagnostics Tests General Mixing Bacterial Suspension Growth of Bacteria and Yeast Washing Procedures Hybridization Staining and Destaining

SmartRun TM : Imbalance Compensation Algorithm Excellent out-of-balance sensor that adjusts the optimum rpm to ensure smooth operation without any vibration SmarTouch TM : Large 5.7' intuitive touchscreen displays every parameter and status of your shaker at glance Easy-to-use design enable to set parameter precisely Historical setting can easily track and review from the touchscreen Transparent Acrylic Hood Durable and only half as heavy as glass Clear cover allows easy viewing of samples Door sensor pauses the driver rotation when the chamber door is open 4 TriDrive TM : Triple-Eccentric Counterbalanced Drive System Robust triple eccentric counterbalanced drive supports long service life Two types of orbit (19 mm and 25 mm) that meets different applications Brushless DC motor provides consistent and no vibration rotation Wide Speed Range: 15-575 rpm Low noise and low heat emission Installed with acceleration / deceleration circuit, to prevent spillage TM Large Capacity with Slim Structure Maximum capacity of 30 Kg Leveling Feet Built-in leveling feet that can be adjusted to level the unit Precise and Wide Temperature Range Refrigerated: 15 C below ambient to 80 C Non-refrigerated: 5 C above ambient to 80 C Built with force convection ventilation to ensure accurate temperature avoiding possible deviations during the operation 37 C ± 0.5 C temperature variation 37 C ± 0.5 C temperature fluctuation Environment-friendly design World-class compressor with low energy consumption Temperature sensor stops the heater or compressor in any exceeded temperature AS-1 and ISB1 Laboratory Shakers

Access Port Ergonomic design that gives easy access for temperature validation and mapping Ethernet Port Port provided for connection to an external PC Allows communication with Esco Voyager software program for monitoring and control USB Port Easy access to transport data log and alarm log to an external hard disk Gas Manifold Port Add versatility for aerobic and anaerobic cultivation 5 Connecting Alarm Contacts Located at the back of the unit to monitor speed, shaker imbalance and power recovery alarms Powder Coat Easy to clean external surface coated with Isocide TM to eliminate 99.9% of surface bacteria within 24 hours of exposure Application List Cell Culture Solubility Extraction Procedures Diagnostics Tests General Mixing Bacterial Suspension Growth of Bacteria and Yeast Washing Procedures Hybridization Staining and Destaining

Airflow Circulation Two circulating fans located on top of the perforated panel, disperse and distribute the air inside the chamber Perforation located below the circulating fan absorbs the air to recirculate the air inside the chamber Platform performs counterclockwise rotation based on the motor drive motion Air temperature changes during suction process - For refrigerated unit, evaporator located behind the perforated panel will cool down the air Discharge Air Suction Air Circulating Air Motor Drive Rotation - For non-refrigerated unit, heater located below the circulating fan will heat up the air Displays the status of speed at which the shaker is currently rotating A graphical interface indicates shaker performance through an alphanumeric display. It presents the status of rpm, time and system running that are activated by programming access through the membrane buttons Deactivates the set alarm during the end of a timed run and deviations on speed and temperature setpoint 6 100 SHAKER V.01 SPEED (RPM) : 100 TIME (MIN) : 010 SYSTEM RUNNING : 0010 The Shaker LED light displays green to indicate that the shaker is operational accessible These keypad buttons control the settings and program system running as required for the application. Gives access to default settings and classified menus Allows navigation and set up the desired program with accuracy and precision An advanced and intuitive touchscreen that provides clear and accurate conditions of the operation to keep track the performance of each features and functions set on the program Status Indicator: Displays the basic yet important parameters and factors of a program. It shows careful conditions of the program for an accessible observation of the operation (i.e. lid closure, running program, temperature) Home Button: Provides major icons for easy navigation on important functions Help Button: Explains the icons displayed on the screen interface Menu Button: Access specific features for setting desired program Diagnostic Screen: Provides readout of current system parameters, date and stamp of all historical alarm, and graph datalog Alarm Button: An option to the alarm function to make it audible or mute Shaker Platform Button: Access to start / stop the platform Voyager Remote Monitoring, datalogging, programming software Esco Voyager is a PC-based software package developed for the remote monitoring and programming device configuration of Esco thermostatic products.

Guide to Models AS - 1 - C - 19 1st Placeholder Product Line 1st 2nd Placeholder External Dimension 2nd 3rd Placeholder CO2 Resistance 3rd 4th Placeholder Orbit Size 4th 19 mm 19 Resistant C 25 mm 25 Ambient Shaker AS 454 x 432 x 160 mm 1 19 mm 19 Non-resistant NC 25 mm 25 Guide to Models ISB1 - R - 19-1 1st Placeholder Product Line 1st 2nd Placeholder Temperature 2nd 3rd Placeholder Orbit Size 3rd 4th Placeholder Electrical 4th 220-240 VAC, 50 Hz 1 19 mm 19 110-130 VAC, 60 Hz 2 Refrigerated R 230 VAC, 60 Hz 3 220-240 VAC, 50 Hz 1 25 mm 25 110-130 VAC, 60 Hz 2 Incubator Shaker Benchtop ISB1 230 VAC, 60 Hz 3 220-240 VAC, 50/60 Hz 8 19 mm 19 Non-refrigerated NR 110-120 VAC, 50/60 Hz 9 7 220-240 VAC, 50/60 Hz 8 25 mm 25 110-120 VAC, 50/60 Hz 9 OrbiCult TM Ambient Shaker Model AS-1-C-19 1 3 2 160 mm (6.3") 454 mm (17.9") 432 mm (17.0") 4 5 6 1. Control Display 2. rpm Display 3. Platform (Interchangeable) 4. Analog Output 5. Alarm Contact 6. Power Plug 7. Leveling Feet 7

OrbiCult TM Incubator Shaker Benchtop Model ISBI-R-19-1 1 2 3 9 4 5 585 mm (23.0") 10 11 6 7 8 12 13 584 mm (23.0") 14 15 605 mm (23.8") 55 956 mm (37.6") 8 16 1. Circulation Fan 2. Door Switch 3. Gas Manifold 4. Temperature Sensor 5. Platform 6. Touchscreen Control 7. On / Off Switch 8. Power Plug 9. Alarm Contact 10. Analog Output 11. Ethernet Port 12. Gas Inlet Filling 13. Leveling Feet 14. Transparent Acrylic Hood 15. Access Port 16. USB Port 815 mm (32.0") Electrical Supply Model Item Voltage Frequency ISB1 - R - 19-1 2200005 1 230 VAC 50 Hz ISB1 - R - 25-1 2200007 ISB1 - R - 19-2 2200006 2 115 VAC 60 Hz ISB1 - R - 25-2 2200008 ISB1 - R - 19-3 2200015 3 230 VAC 60 Hzv ISB1 - R - 25-3 2200016 ISB1 - NR - 19-8 2200009 8 230 VAC 50 / 60 Hz ISB1 - NR - 25-8 2200011 ISB1 - NR - 19-9 2200010 9 115 VAC 50 / 60 Hz ISB1 - NR - 25-9 2200012 AS1-1-C-19 2200002 AS1-1-C-25 2200004 1 100-240 VAC 50 / 60 Hz AS1-1-NC-19 2200001 AS1-1-NC-25 2200003

Ordering Infromation Accessories Item Item Name Description Clamp Capacity Platform List (Dedicated) 5270019 P1 Platform Dedicated 25 ml 330 x 330 mm (13.0" x 13.0") for 25 ml 36 5270020 P1 Platform Dedicated 50 ml 330 x 330 mm (13.0" x 13.0") for 50 ml 36 5270021 P1 Platform Dedicated 125 ml 330 x 330 mm (13.0" x 13.0") for 125 ml 16 5270022 P1 Platform Dedicated 250 ml 330 x 330 mm (13.0" x 13.0") for 50 ml 10 5270023 P1 Platform Dedicated 300 ml 330 x 330 mm (13.0" x 13.0") for 300 ml 10 5270024 P1 Platform Dedicated 500 ml 330 x 330 mm (13.0" x 13.0") for 500 ml 9 5270025 P1 Platform Dedicated 1 L 330 x 330 mm (13.0" x 13.0") for 1 L 5 5270026 P1 Platform Dedicated 2 L 330 x 330 mm (13.0" x 13.0") for 2 L 4 5270027 P1 Platform Dedicated 2.8 L 330 x 330 mm (13.0" x 13.0") for 2.8 L 1 5270028 P1 Platform Dedicated 3 L 330 x 330 mm (13.0" x 13.0") for 3 L 1 5270029 P1 Platform Dedicated 4 L 330 x 330 mm (13.0" x 13.0") for 4 L 1 5270030 P1 Platform Dedicated 5 L 330 x 330 mm (13.0" x 13.0") for 5 L 1 5270031 P1 Platform Dedicated 6 L 330 x 330 mm (13.0" x 13.0") for 6 L 1 5270032 P3 Platform Dedicated 25 ml 457 x 457 mm (18.0" x 18.0") for 25 ml 64 5270033 P3 Platform Dedicated 50 ml 457 x 457 mm (18.0" x 18.0") for 50 ml 64 5270034 P3 Platform Dedicated 125 ml 457 x 457 mm (18.0" x 18.0") for 125 ml 36 5270035 P3 Platform Dedicated 250 ml 457 x 457 mm (18.0" x 18.0") for 250 ml 16 5270036 P3 Platform Dedicated 300 ml 457 x 457 mm (18.0" x 18.0") for 300 ml 16 5270037 P3 Platform Dedicated 500 ml 457 x 457 mm (18.0" x 18.0") for 500 ml 16 5270038 P3 Platform Dedicated 1 L 457 x 457 mm (18.0" x 18.0") for 1 L 9 5270039 P3 Platform Dedicated 2 L 457 x 457 mm (18.0" x 18.0") for 2 L 5 5270040 P3 Platform Dedicated 2.8 L 457 x 457 mm (18.0" x 18.0") for 2.8 L 4 5270041 P3 Platform Dedicated 3 L 457 x 457 mm (18.0" x 18.0") for 3 L 4 5270042 P3 Platform Dedicated 4 L 457 x 457 mm (18.0" x 18.0") for 4 L 4 5270043 P3 Platform Dedicated 5L 457 x 457 mm (18.0" x 18.0") for 5 L 4 5270044 P3 Platform Dedicated 6 L 457 x 457 mm (18.0" x 18.0") for 6 L 2 5270046 P4 Platform Dedicated 50 ml 457 x 610 mm (18.0" x 24.0") for 50 ml 80 5270047 P4 Platform Dedicated 125 ml 457 x 610 mm (18.0" x 24.0") for 125 ml 48 5270048 P4 Platform Dedicated 250 ml 457 x 610 mm (18.0" x 24.0") for 250 ml 35 5270049 P4 Platform Dedicated 300 ml 457 x 610 mm (18.0" x 24.0") for 300 ml 35 5270050 P4 Platform Dedicated 500 ml 457 x 610 mm (18.0" x 24.0") for 500 ml 20 5270051 P4 Platform Dedicated 1 L 457 x 610 mm (18.0" x 24.0") for 1 L 12 5270052 P4 Platform Dedicated 2 L 457 x 610 mm (18.0" x 24.0") for 2 L 6 5270053 P4 Platform Dedicated 2.8 L 457 x 610 mm (18.0" x 24.0") for 2.8 L 5 5270054 P4 Platform Dedicated 3 L 457 x 610 mm (18.0" x 24.0") for 3 L 5 5270055 P4 Platform Dedicated 4 L 457 x 610 mm (18.0" x 24.0") for 4 L 5 5270056 P4 Platform Dedicated 5 L 457 x 610 mm (18.0" x 24.0") for 5 L 4 5270057 P4 Platform Dedicated 6 L 457 x 610 mm (18.0" x 24.0") for 6 L 4 9

Ordering Infromation Accessories Item Item Name Description 25 ml 50 ml 125 ml 250 ml 300 ml 500 ml 1 L 2 L 2.8 L 3 L 4 L 5 L 6 L 5270016 P1 Universal 330 x 330 mm (13.0" x 13.0") 36 36 13 9 9 9 4 4 1 1 1 1 1 Platform List (Universal) 5270017 P3 Universal 457 x 457 mm (18.0" x 18.0") 64 64 32 16 16 16 8 5 4 4 4 4 2 5270018 P4 Universal 457 x 610 mm (18.0" x 24.0") 70 35 20 20 20 12 8 5 5 5 4 3 Accessories Item Description Tube per Rack 5270072 Small 8-11 mm Test Tube Racks 40 5270073 Small 12-15 mm Test Tube Racks 21 5270074 Small 16-19 mm Test Tube Racks 10 5270075 Small 20-22 mm Test Tube Racks 10 5270076 Small 23-26 mm Test Tube Racks 5 5270077 Small 27-33 mm Test Tube Racks 5 5270078 Medium 8-11 mm Test Tube Racks 64 5270079 Medium 12-15 mm Test Tube Racks 33 Test Tube Racks 5270080 Medium 16-19 mm Test Tube Racks 18 5270081 Medium 20-22 mm Test Tube Racks 16 5270082 Medium 23-26 mm Test Tube Racks 8 5270083 Medium 27-33 mm Test Tube Racks 8 5270002 Large 8-11 mm Test Tube Racks 88 10 5270003 Large 12-15 mm Test Tube Racks 48 5270004 Large 16-19 mm Test Tube Racks 24 5270005 Large 20-22 mm Test Tube Racks 22 5270006 Large 23-26 mm Test Tube Racks 11 5270007 Large 27-33 mm Test Tube Racks 11 5270059 25 ml Clamps 5270060 50 ml Clamps 5270061 125 ml Clamps 5270062 250 ml Clamps 5270063 300 ml Clamps Clamps 5270064 500 ml Clamps 5270065 1 L Clamps 5270066 2 L Clamps 5270067 2.8 L Clamps 5270068 3 L Clamps 5270069 4 L Clamps 5270070 5 L Clamps 5270071 6 L Clamps Microplate Holder 5270008 Microplate Holder-Small 5270009 Microplate Holder-Medium 5270010 Microplate Holder-Large Utility Carrier 5270011 Utility Carrier, P1-330 x 300 mm (13.0" x 12.0") 5270012 Utility Carrier, P3-460 x 430 mm (18.0" x 17.0") Other Accessories 5270013 Voyager Software Kit TM 5270014 Adhesive Mat Platform (200 x 200 x 3 mm) AS-1 and ISB1 Laboratory 5270015 Shakers 12 Port Gassing Manifold

Universal Platform Have standard holes pattern that can fit any flask clamps and test tube rack. All multiple flask clamps and labware holders are shipped separately and installed by the end user. Clamps Single-piece stainless steel clamps that provide enough strength and security to hold flasks. Dedicated Platform Platforms have a customized pattern to optimize the number of a particular size of flask clamp on a platform. Dedicated platforms are pre-installed with the flask clamps. Voyager Software Kit A PC-based software package developed for the remote monitoring, data logging and programming / device configuration of Esco controlled environment laboratory equipment. Sticky Mats Allows the user to place the flask directly on the mat without the use of a clamp. Sticky mats are very convenient if the user desires to rotate at less than 350 rpm. This can be ordered separately and attach on Universal Platform. Test Tube Rack Stainless steel rack that stabilizes and hold the test tubes. TECHNICAL SPECIFICATION Model AS-1-NC-19 AS-1-NC-25 AS-1-C-19 AS-1-C-25 ISB1-NR-19 ISB1-NR-25 ISB1-R-19 ISB1-R-25 Orbit 19 mm (0.7") 25 mm (1.0") 19 mm (0.7") 25 mm (1.0") 19 mm (0.7") 25 mm (1.0") 19 mm (0.7") 25 mm (1.0") Speed 15-575 rpm rpm Accuracy ± 1 11 Display Digital LED and 4 line LCD message center Colored Touchscreen Timer 9999 minutes 999 hrs and 59 minutes Interchangeable Platform and Platform Size P1, 330 x 330 mm (13.0" x 13.0") P3, 457 x 457 mm (18.0" x 18.0") P4, 457 x 610 mm (18.0" x 24.0") P3, 457 x 457 mm (18.0" x 18.0") Maximum Load 30 Kg (66.1 lbs) 25 Kg (55.1 lbs) 30 Kg (66.1 lbs) 25 Kg (55.1 lbs) 30 Kg (66.1 lbs) 25 Kg (55.1 lbs) 30 Kg (66.1 lbs) 25 Kg (55.1 lbs) External Dimension (W x D x H) 458 x 422 x 184 mm (18.0" x 16.6" x 7.2") 560 x 820 x 625 mm (22.0" x 32.3" x 24.6") Net Weight 23 Kg (50.7 lbs) 23 Kg (50.7 lbs) 27 Kg (59.5 lbs) 27 Kg (59.5 lbs) 70 Kg (154.3 lbs) 70 Kg (154.3 lbs) 80 Kg (176.4 lbs) 80 Kg (176.4 lbs) CO 2 Resistance No Yes External Cover Material UL 94 Flammability Standard, V-0 requirement made of ABS plastic Cabinet Construction Base Main Workzone 3.0 mm (0.1") 18 gauge EG Steel with Isocide TM antimicrobial powder coating 2.0 mm (0.07") 18 gauge EG Steel with Isocide TM antimicrobial powder coating 2.0 mm (0.07") 16 gauge Stainless Steel type 304 Temperature Range 5 C (above ambient) - 80 C 15 C (below ambient) - 80 C Shipping Weight 27 Kg (59.5 lbs) 90 Kg (198.4 lbs) 100 Kg (220.5 lbs) Shipping Dimension (W x D x H) 650 x 660 x 450 mm (26.0" x 25.6" x 17.7") 720 x 1120 x 860 mm (44.1" x 28.4" x 33.9") Shipping Volume, Maximum 0.2 m 3 (7.1 cu.ft.) 0.7 m 3 (24.7 cu.ft.)

ESCO Global Network ART Equipment Biological Safety Cabinets CO 2 Incubators Cold Storage Compounding Pharmacy Equipment Containment / Pharma Products Ductless Fume Hoods Lab Animal Research Products Laboratory Fume Hoods Laboratory Incubators Laboratory Ovens Laminar Flow Cabinets Laboratory Freeze Dryers PCR Cabinets PCR Thermal Cyclers Powder Weighing Balance Enclosures The Esco Group of Companies is a global life sciences tools provider with sales in over 100 countries. The group is active in lab equipment, pharma equipment and medical devices. Manufacturing facilities are located in Asia and Europe. R&D is conducted worldwide spanning the US, Europe and Asia. Sales, service and marketing subsidiaries are located in 12 major markets including the US, UK, Singapore, Japan, China and India. Regional distribution centers are located in the US, UK, and Singapore. Life Science Chemical Research Assisted Reproductive Technology (ART) Pharmaceutical Equipment General Equipment Esco Technologies, Inc. 903 Sheehy Drive, Suite F, Horsham, PA 19044, USA Toll-Free USA and Canada 1-877-479-3726 Tel 215-441-9661 Fax 484-698-7757 eti.sales@escoglobal.com www.escolifesciences.us Esco Micro Pte. Ltd. 21 Changi South Street 1 Singapore 486 777 Tel +65 6542 0833 Fax +65 6542 6920 mail@escoglobal.com www.escoglobal.com 9010277_Orbicult_Brochure_A4_vA_05/27/15 Esco can accept no responsibility for possible errors in catalogues, brochures and other printed materials. Esco reserves the right to alter its products and specifications without notice. All trademarks and logotypes in this material are the property of Esco and the respective companies. Esco Global Offices: Sydney, Australia Manama, Bahrain Beijing, China Chengdu, China Guangzhou, China Shanghai, China Kowloon, Hong Kong Bangalore, India Delhi, India Mumbai, India Jakarta, Indonesia Rome, Italy Osaka, Japan Kuala Lumpur, Malaysia Melaka, Malaysia Manila, Philippines Moscow, Russia Singapore Midrand, South Africa Seoul, South Korea Bangkok, Thailand Barnsley, United Kingdom South Yorkshire, United Kingdom Philadelphia, PA, USA Hanoi, Vietnam Esco Micro Pte Ltd Cert. No: 651076 PT Esco Bintan Indonesia Cert. No: 651333/E PT Esco Bintan Indonesia Cert. No: Q2N130383797001