SCINTOMICS Liquid Chromatography Always the right system for your needs.
SCINTOMICS: Always the right system for your needs Advanced Research Daily QC Routine and beyond High Performance analytical/semi-preparative Radio-HPLC that covers all needs of modern radiopharmaceutical research and quality control. Data Acquisition and management with Clarity software package. Exceptional cost/performance ratio. Many options and features serve all your needs. High Performance analytical Radio-HPLC that makes your daily QC routine as simple as a click. With Azura Mobile Control SW the intuitive user interface that runs on mobile devices. Your daily routine always just a click away, always ready, always right. Expandable with options (e.g. auto sampler). 2
High-end performance and powerful features in combination with an exceptional cost/performance ratio. Encapsulated optics design to protect the optical components from fine dust or harmful gases, providing high detection sensitivity and a very stable baseline. Seya-Namioka Monochromator and a new blazed Holographic Concave Grating enhance light intensity, ensuring high sensitivity over the entire wavelength range. Automatic seal rinsing for improved longevity. Automatic compressibility compensation ensures highly precise flow rates. Optional vacuum degasser for complete removal of dissolved gases and air bubbles. Column compartment with Peltier elements for accurate temperature control (4 C up to 90 C) and high retention time reproducibility. Integrated tray to safely house solvent bottles. 3
SCINTOMICS HPLC: Pumps SCI8112 Isocratic Pump Operating principle: parallel dual-plunger pump No mixing valve Easily upgraded to SCI8110 Quaternary pump SCI8110 Quaternary Pump Operating principle: parallel dual-plunger pump Low-pressure gradient Number of solvents: up to 4 solvents Gradient formation: 4-channel mixing valve Composition precision: < 0.1 % Composition accuracy: < 0.5 % General Pump Specifications Automatic compressibility compensation Flow range: Analytical: 0.001-10 ml/min Semi-prep: 0.01-50 ml/min Flow rate accuracy: ± 1 % at 1 ml/min Flow rate precision: 0.1 % RSD at 1 ml/min Maximum pressure Analytical Cell 6000 psi / 410 bar: 0-5 ml/min 3000 psi / 205 bar: 5-10ml/min Semi-prep. Cell 3500 psi / 240 bar: 0-35ml/min 2500 psi / 170 bar: 35-50ml/min SCI8111 Binary Pump Operating principle: parallel dual-plunger pump High-pressure gradient Number of solvents: 2 Semi-automatic prime/purge Leak detection Diagnostics Error detection 4
SCINTOMICS HPLC: Detectors SCI8160 PDA Detector Slit bandwidth: 1.7 nm No. of PDA channels: 1024 Pixel resolution: 0.9 nm Wavelength: 190-950 nm Analytical Cell Path-length: 3 mm Pressure : < 1,500 psi Volume : 5 µl Semi-prep. Cell Path-length: 10 mm Pressure : < 1,500 psi Volume : 13 µl Noise level: < ± 2 10-5 AU (empty cell, 1 sec rise time, 254 nm) Drift: < 2 10-4 AU/hr (baseline correction), 0.001AU/hr (room temp) Wavelength accuracy: < 1 nm ( HY-1 Holmium Oxide filter) GLP compliance: photometric accuracy, linearity, noise nevel, drift System check SCI8120 UV/Vis Detector Wavelength range: 190-900 nm Data collection rate: up to 50Hz Light source: Deuterium & Tungsten lamp Noise level: < ±0.35 10-5 AU, 254 nm, dry cell Drift: < 1 10-4 AU/hr Bandwidth: 5 nm Wavelength accuracy: ±1 nm Wavelength precision: ±0.1 nm Linearity: >99.5 % for 2.5 AU (acetone, 254 nm) Path length: 10 mm (analytical cell) 3 mm (semi-prep cell) Cell volume: 10 µl (analytical cell) 5 µl (semi-prep cell) RI range: 1.00 1.75 RIU Noise: 5 10-9 RIU (analytical) 10 10-8 RIU (semi-prep) Flow cell vol: 7 µl (analytical), 9 µl (semi-prep) Cell pressure: 6 kg/cm 2 (5.8 bar, 84 psi) RS232 control 5
SCINTOMICS HPLC: Options SCI8101 Vacuum Degasser Number of channel: 4 channels Maximum flow rate: 10 ml/min per channel > 0 2.0 ml/ min per channel for removal of 70 % gas from Methanol Internal volume per channel : 925 µl per channel Materials in contact with solvent: Teflon and PEEK Electrochemical Detector (ECD) ECD is a detector for HPLC applied to variable analyses such as biogenic amines, phenols, vitamins, DNA adducts, inorganic ions and amino acids. Fluorescence Detector (FLD) SCI8131 Column Compartment Temperature range: 4 C (cooling) - 90 C Temperature stability: ±0.05 C Temperature accuracy: ±0.5 C Temperature programs: 40 Steps Column capacity: Analytical: max. 3 of 30 cm column (max. OD 18 mm) Semi-prep: max. 2 of 30 cm column Heat-up time: 16 minutes from 4 C to 80 C Cool-down time: 13 minutes from 80 C to 4 C Column switching: max. two automatic 6-port valve (optional) FLD is a highly sensitive, scanning fluorescence detector for liquid chromatography. It provides exceptional optical performance and operational flexibility for routine and trace analysis. 6
SCINTOMICS HPLC: System Manual Injector Rheodyne 7725i / 9725i Industry standard manual injector Analytical: 7725i (SUS) and 9725i (PEEK) Semi-prep: 3725i Column Switching Valves MX Series II (Stand-alone) automated high-pressure fluidic valves provides productivity enhancing solutions for today s demanding analytical methods. Combine MX Series II modular valves with your current instrument to support complex fluid switching and sample injection needs. TitanHP consists of an integrated driver/actuator and a removable liquid-end (Rapid Replacement Pod ) to provide a single, flexible space saving design. DuraLife wear surfaces extends valve lifetime, which means reduced field service and more customer analysis time between replacements of the wetted surfaces SCI8150 Autosampler a high-throughput autosampler with state of the art injection technology, fast injection and wash cycles, and an optional Peltier chiller/heater for samples. Full or partial loop injection along with Pressure-Assisted-Sample-Aspiration (PASA) is possible. The highly efficient needle and internal capillary wash virtually eliminates sample carry-over. Cycle time, including wash, is less than one minute. 96 standard 2 ml vials (32 mm x 12 mm) or well plates (96 or 384 capacity, deep or shallow) can be used. Sample capacity: analytical: 2 micro well plates according to SBS standards; semi-prep: 24 vials of 10 ml (LSV) Loop volume: 1-9999 µl programmable Reproducibility: RSD 0.3 % for full loop injections RSD 0.5 % for partial loopfill injections, RSD 1.0 % for µl pickup injections Carry-over: < 0.05 % RS232 Control Cooling/Heating option: 4 C 40 C 7
a robust Radio-HPLC System for a wide range of standard applications. Controlled via Mobile Control tablet app or Clarity Chrom Software. 8
AZURA: For a wide range of standard applications. AZURA Compact HPLC system is based on the multifunctional element ASM 2.1L. This element integrates up to 3 modules in one functional and space-saving unit, e.g. A degasser for a smooth baseline, a precise isocratic pump with low pulsation, and a variable UV wavelength detector. The system is supported by the Clarity Chrom software package and can also be controlled directly via the intuitive Mobile Control. Ultimate flexibility: Choose from a variety of integratable modules: P 4.1S: Pump with pressure transducer P 2.1S: Pump without pressure transducer DG 2.1S: Degasser 2-channel or 4-channel UVD 2.1S: UV/VIS detector V 2.1S: Valve drives VICI Valco valve drives Manual injection valve 9
AZURA Mobile Control Mobile Control is an intuitive software solution, easy-to-understand and to use, even for less experienced users. Controls and monitors AZURA devices and systems and performs measurements and methods. Detector traces, auxiliary traces and method parameters can be recorded, graphically depicted, analyzed, reported and exported at the click of a button. System overview provides instant insight into device and system status and allows to adjust key parameters with a fingertip. Smart user management makes the Mobile Control TM safe; ensuring that device parameters only be changed by authorized operators. Graphical display helps to avoid problems and unexpected downtime and to plan maintenance controls. Hand-held Mobile Control TM option to check the system remotely, allowing to oversee multiple systems from the comfort of your office Regular updates enable you to take advantage of new devices, features and functions as soon as they are released. 10
COMPACT Radio-HPLC: The ideal partners for GRP-Modules Compact-HPLC devices with modern technology and impressive performance, directly controllable by Scintomics Control Center (SCC) Software and GRP User Interface. The ideal partners for GRP-Modules. UV-DETECTOR 2.1S Wavelength range: 190-500 nm Deuterium (D2) lamp with integrated GLP chip Noise: ± 2.0 10-5 AU at 254 nm Drift: 3.0 10-4 AU/h at 254 nm Linearity: > 2.0 AU at 270 nm input 100-240 V, output 24 V DC, 60 W 121 x 129 x 187 mm 3 (W x H x D), 1.5 kg Double-piston PUMP P4.1S Integrated pressure sensor 0.1-10 ml/min or 0.1-50 ml/min, ceramic/stainless steel Max. pressure: 400 bar (#1), 150 bar (#2) Flow rate accuracy: deviation ±1.0%, measured at 5-50% of flow range using ethanol/water 10:90 Precision: 0.5% RSD (1 ml/min,12 MPa), measured at 1 ml/min using ethanol/water 10:90 113 x 135 x 225 mm 3 (W x H x D), 2.4 kg Injection Valve V2.1S 6-Port/2-positions Stainless steel, Valcon E3, 1/16 capillary connection 105 x 100 x 185 mm 3 (W x H x D), 1.9 kg, both without valve External DC 24V, 60 W Degasser DG 2.1S 2 channels Gas permeation through fluoropolymer membrane, max 10 ml/min Dead volume approx. 285 µl per channel Maximum pressure stability 7 bar Wetted materials PEEK, glass-filled PTFE, Teflon AF 121 x 138 x 190 mm 3 (W x H x D), 2,3 kg, 85-265 V, 50-60 Hz, 20 W Ambient conditions temperature range: 4-40 C, 39.2-104 F Air humidity: below 90%, non-condensing 11
SCINTOMICS GmbH Global Radiopharmacy Technology Lindach 4 82256 Fürstenfeldbruck / Germany T +49 (0) 8141 150 55-0 F +49 (0) 8141 150 55-15 info@scintomics.com www.scintomics.com