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Centrifuge Guide www.sysmex.nl www.sysmex.be

Content Love Life and Donate Sorvall Legend Micro 17 and Legend Micro 21 Microcentrifuge Sorvall ST 8 and ST 8R Benchtop Centrifuge Sorvall ST 16 and ST 16R Benchtop Centrifuge Sorvall ST 40 and ST 40R Benchtop Centrifuge Sorvall Legend X1 and X1R Benchtop Centrifuge Sorvall Legend XT and Legend XTR Benchtop Centrifuge Sorvall Legend XF and Legend XFR Benchtop Centrifuge Sorvall LYNX 4000 Superspeed Centrifuge Sorvall LYNX 6000 Superspeed Centrifuge Sorvall MTX 150 Benchtop Micro-Ultracentrifuge Sorvall MX 120 Plus Floorstanding Micro-Ultracentrifuge Sorvall MX 150 Plus Floorstanding Micro-Ultracentrifuge Sorvall WX 100+, WX 90+, WX 80+ Floorstanding Ultracentrifuges Sorvall RC3BP Plus Low-speed Centrifuge Sorvall RC 12BP Plus Large Capacity Centrifuge Sorvall RC BIOS Centrifuge Rotor Care & Safety Program 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 35 www.sysmex-against-cancer.eu 3

Sorvall Legend Micro 17 and Legend Micro 21 Microcentrifuge Specifications Legend Micro 17/17R Legend Micro 21/21R 24 x 2 ml (with 24 x 1.5/2.0 ml rotor) 13.300 rpm 14.800 rpm 17.000 x g 14.800 x g Temperature Set Range * -9 C to +40 C per 1 C increment * Pulse (Short) Run Yes Acceleration/Deceleration Rates 8/9 seconds; 12/12 seconds Time Set Range 1 min 99 min; 1 min increments + HOLD mode Sound Level (dba) 56 dba (ventilated), 50 dba (refrigerated) CSA certified, CE marked, IVD compliant, Certified Biosafety Legend ventilated, 230 V, 50/60 Hz Including 24 x 1.5/2.0 ml rotor Legend ventilated, 230 V, 50/60 Hz Including hematocrit rotor Legend refrigerated, 230 V, 50/60 Hz Including 24 x 1.5/2.0 ml rotor Legend refrigerated, 230 V, 50/60 Hz Including hematocrit rotor * Refrigerated models only Thermo Scientific Legend Micro 17 and Legend Micro 21 Microcentrifuges combining power, versatility and convenience in a safe and compact instrument. With intuitive controls and ClickSeal Biocontainment lid, the Legend Micro 17 and 21 microcentrifuges are perfect to support micro-volume protocols such as nucleic acid or protein lysate preparation and PCR reaction set-up. 22.5 x 24.3 x 35.2 cm 22.5 x 24.3 x 35.2 cm (33.0 x 29.5 x 44.5 cm) * (33.0 x 29.5 x 44.5 cm) * 10.5 kg 28.0 kg 10.5 kg 28.0 kg 75002430 75002435 75002493 75002487 75002440 75002445 N/A 75002489 PCR Strips Rotors Hematocrit Rotor 24 x 1.5/2.0 ml max 21.100 x g A standard rotor with exceptional versatility. 24 Tubes per run from basic microtube processing to mini-preps and spin columns. Additional flexibility with available adapters. 36 x 0.5 ml max 19.300 x g Two rows with a total of 36 places for a higher throughput of smaller microtubes. Dual Row rotor 18 x 2.0/0.5 ml max 20.800 x g This rotor eliminates the need of adapters with its dual row to support two tube volumes. PCR 8 x 8 max 17.100 x g Accommodate up to 8 PCR strips at one time or 64 individual tubes. PCR 4 x 8 max 16.200 x g Process up to 4 PCR strips or 32 individual PCR tubes with certified sample protection. PCR 4 x 8 max 16.200 x g Process up to 4 PCR strips or 32 individual PCR tubes with certified sample protection. Hematocrit Rotor max 16.800 x g Achieve capillary seperations in less than 5 minutes with included linear scale to read results. With a capacity of 24 capillaries. 4 Sorvall Legend Micro 17 and 21 are registered products of Thermo Scientific www.thermoscientific.com. 5

Sorvall ST 8 and ST 8R Benchtop Centrifuge Thermo Scientific Sorvall ST 8R Benchtop centrifuge combining a compact design with the flexibility to adapt with evolving clinical and research needs. A large range of rotor and adapters with different capacities and a top speed of 16.000 rpm or 24.328 x g. TX-150 max 3.260 x g Designed for a broad range of swing-out processing needs at high speed and high capacity with the flexibility of available adapters. M-10 max 2.576x g Centrifuges up to 4 microplates or 2 deepwell plates complemented by Auto-Lock rotor exchange. MT-12 max 16.438 x g Unique design capable of spinning up to 12 x 1.5/2 ml microtubes and filtration columns, ideal for small-volume research applications. Specifications Sorvall ST 8 Sorvall ST 8R (refrigerated) 4 x 145 ml (with TX-150) 4.500 rpm (with TX-150) 3.260x g (with TX-150) 6 x 50 ml (with HIGHConic III) 16.000 rpm (with HIGHConic III) 24.328 x g (with HIGHConic III) Direct, brushless induction low profile motor Auto-Lock Imbalance Detection System SMARTSpin 4, direct access Temperature Set Range 10 C to +40 C Pre-Cooling Function Yes, with direct button Refrigeration System CFC free Pulse (Short) Run Yes Acceleration Rates 2 Deceleration Rates 2 Max Timer Range 9 h, 99 min + continuous Sound Level (dba) < 58 dba (with TX-150 rotor) Certified ClickSeal biocontainment system, language selection 31 x 37 x 48 cm 91.5 kg Sorvall ST 8, 230 V, 50/60 Hz 75007201 75007204 HIGHConic III max 10.155 x g Process 6 x 50 ml tubes in fixed angle configuration and at RCF above 10.000 x g in certified sealed conditions. CLINIConic max 3.030 x g Spin 30 x 15 ml round or conical tubes up to 5.000 x g and ensure acceleration and throughput for cell culture applications. Hematocrit rotor max 16.800 x g Dedicated blood processing to achieve capillary seperations. Micro-Volumes Rotors MicroClick 30 x 2 max 21.693 x g MicroClick 24 x 2 max 24.328 x g 8 x 8 PCR strip max 17.860 x g 6 Sorvall ST 8 is a registered product of Thermo Scientific www.thermoscientific.com. 7

Sorvall ST 16 and ST 16R Benchtop Centrifuge Thermo Scientific Sorvall ST 16 and ST 16R Benchtop centrifuges combining unmatched capacity, ergonomics and value for routine processing needs. Unmatched capacity with 4 x 400 ml and a wide range of adapters for all applications, combined with a top speed of 25.830 x g. TX-200 AND TX-40 max 5.580 and 4.496 x g resp. Designed for a broad range of laboratory throughput needs, with a capacity range of 32 to 76 blood tubes and up to 16 conical tubes in a single run, for the highest configuration flexibility on the market. M-20 max 2.272 x g Centrifuges up to 6 microplates in certified sealed conditions with transportable carriers and the versatility of Auto-Lock rotor installation. BIOShield 720 max 5.088 x g Runs frequently used tubes above 5.000 x g with the confidence and simplicity of a single, certified biosafety lid. Specifications Sorvall ST 16 Sorvall ST 16R (refrigerated) 4 x 400 ml (with TX-400) 5.500 rpm (with TX-200) 5.580 x g (with TX-200) 6 x 100 ml (with F15-6x100) 15.200 rpm (with 30 x 2 ml rotor) 25.830 x g (with 30 x 2 ml rotor) Direct, brushless induction low profile motor Auto-Lock III Imbalance Detection System SMARTSpin 6, direct access Temperature Set Range 10 C to +40 C Pre-Cooling Function Yes, with direct button Refrigeration System CFC free Pulse (Short) Run Yes Acceleration Rates 9 Deceleration Rates 10 Max Timer Range 9 h, 99 min + continuous Sound Level (dba) < 61 dba (TX-400) < 55 dba (TX-400) Certified ClickSeal biocontainment system, language selection 36 x 44 x 60.5 cm 36 x 62.3 x 60.5 cm 57.5 kg 91.5 kg Sorvall ST, 230 V, 50/60 Hz 75004240 75004380 Fiberlite F15-6x100 max 18.516 x g Durable design for general purpose pelleting of organelles, density gradients and various protocols requiring angle centrifugation of disposable conical tubes up to 18.516 x g. HIGHConic II max 10.178 x g Process 6 x 94 ml tubes at up to 10.178 x g in certified sealed conditions. CLINIConic max 4.997 x g Spin 30 x 15 ml round or conical tubes up to 5.000 x g and ensure acceleration and throughput for cell culture and blood separation applications. 8x50 Sealed max 7.177 x g Ideal for TB sputum applications, and other high risk samples, centrifuge 8 conical tubes up to 6.700 rpm in individually sealed vessels, which can be prepared remotely. Micro-Volumes Rotors Microliter 30 x 2 max 25.830 x g 8 Sorvall ST 16 and 16R are registered products of Thermo Scientific www.thermoscientific.com. 9

Sorvall ST 40 and ST 40R Benchtop Centrifuge Thermo Scientific Sorvall ST 40 and ST 40R Benchtop centrifuges combining unmatched capacity, ergonomics and value for routine processing needs. Unmatched capacity with 4 x 750 ml and a wide range of adapters for all applications, combined with a top speed of 25.314 x g. TX-750 max 4.816 x g Delivers maximum flexibility at 4.700 rpm and features a choice of round or rectangular buckets with multiple adapters as well as microplate carriers. TX-1000 max 4.212 x g Significant productivity improvement compared to competitive models (40 % more 50 ml conical tubes, 100 % more blood tubes) with biocontainment sealing or with ertified sealed microplate carriers. BIOShield 1000A max 5.590 x g Runs frequently used tubes above 5.000 x g with the confidence and simplicity of a single, certified biosafety lid. Specifications Sorvall ST 40 Sorvall ST 40R (refrigerated) 4 x 750 ml (with TX-750 ) 5.300 rpm (with BIOShield 1000A rotor) 5.580 x g (with BIOShield 1000A rotor) 6 x 100 ml (with F15-6x100) 15.200 rpm (with 48 x 2 ml rotor) 25.314 x g (with 48 x 2 ml rotor) Direct, brushless induction low profile motor Auto-Lock III Imbalance Detection System SMARTSpin 6, direct access Temperature Set Range 10 C to +40 C Pre-Cooling Function Yes, with direct button Refrigeration System CFC free Pulse (Short) Run Yes Acceleration Rates 9 Deceleration Rates 10 Max Timer Range 9 h, 99 min + continuous Sound Level (dba) < 61 dba (TX-750) < 57 dba (TX-750) Certified ClickSeal biocontainment system, language selection 36 x 56.5 x 67 cm 36 x 74.5 x 67 m 86 kg 116 kg Sorvall ST, 230 V, 50/60 Hz 75004509 75004524 Fiberlite F15-6x100 max 18.516 x g Durable design for general purpose pelleting of organelles, density gradients and various protocols requiring angle centrifugation of disposable conical tubes up to 18.516 x g. HIGHConic II max 10.178 x g Process 6 x 94 ml tubes at up to 10.178 x g in certified sealed conditions. Micro-Volumes Rotors Microliter 48 x 2 max 25.314 x g F21-48x2 max 25.055 x g 10 Sorvall ST 40 and 40R are registered products of Thermo Scientific www.thermoscientific.com. 11

Sorvall Legend X1 and X1R Benchtop Centrifuge Thermo Scientific Sorvall Legend X1 and Legend X1R Benchtop centrifuges featuring market-leading performance, capacity and throughput for high-performance processing. Unmatched capacity with 4 x 400 ml and a wide range of adapters for all research applications, combined with a top speed of 25.830 x g. TX-200 and TX-400 max 5.580 and 4.496 x g resp. Designed for a broad range of laboratory throughput needs, with a capacity range of 32 to 76 blood tubes and up to 16 conical tubes in a single run, for the highest configuration flexibility on the market. M-20 max 2.272 x g Centrifuges up to 6 microplates in certified sealed conditions with transportable carriers and the versatility of Auto-Lock rotor installation. BIOShield 720 max 5.088 x g Runs frequently used tubes above 5.000 x g with the confidence and simplicity of a single, certified biosafety lid. Specifications Sorvall Legend X1 4 x 400 ml (with TX-400 rotor) 6.300 rpm (with BIOShield 720 rotor) 7.144 x g (with BIOShield 720 rotor) 6 x 100 ml (with F15-6x100 rotor) 15.200 rpm (with 30 x 2 ml rotor) 25.830 x g (with 30 x 2 ml rotor) Sorvall Legend X1R (refrigerated) Direct, brushless induction low profile motor Auto-Lock III Imbalance Detection System SMARTSpin 99 (5 with direct access key) Temperature Set Range 10 C to +40 C Pre-Cooling Function Yes, with direct button Refrigeration System CFC free Pulse (Short) Run Yes Acceleration Rates 9 Deceleration Rates 10 Max Timer Range 9 h, 99 min + continuous Sound Level (dba) < 61 dba (TX-400) < 55 dba (TX-400) Certified ClickSeal biocontainment system, language selection 36 x 44 x 60.5 cm 36 x 62.3 x 60.5 m 57.5 kg 91.5 kg Sorvall Legend, 230 V, 50/60 Hz 75004220 75004260 Fiberlite F15-6x100 max 24.652 x g Durable design for general purpose pelleting of organelles, density gradients and various protocols requiring angle centrifugation of disposable conical tubes up to 18.516 x g. HIGHConic II max 15.090 x g Process 6 x 94 ml tubes at up to 10.178 x g in certified sealed conditions. CLINIConic max 4.997 x g Spin 30 x 15 ml round or conical tubes up to 5.000 x g and ensure acceleration and throughput for cell culture and blood separation applications. 8x50 Sealed max 7.177 x g Ideal for TB sputum applications, and other high risk samples, centrifuge 8 conical tubes up to 6.700 rpm in individually sealed vessels, which can be prepared remotely. Micro-Volumes Rotors Microliter 30 x 2 max 25.830 x g 12 Sorvall Legend X1 and X1R are registered products of Thermo Scientific www.thermoscientific.com. 13

Sorvall Legend XT and Legend XTR Benchtop Centrifuge Thermo Scientific Sorvall Legend XT and Legend XTR Benchtop centrifuges featuring market-leading performance, capacity and throughput for high-performance processing. Unmatched capacity with 4 x 750 ml and a wide range of adapters for all research applications, combined with a top speed of 25.314 x g. TX-750 max 4.816 x g Delivers maximum flexibility at 4.700 rpm and features a choice of round or rectangular buckets with multiple adapters as well as microplate carriers. TX-1000 max 4.122 x g Significant productivity improvement compared to competitive models (40 % more 50 ml conical tubes, 100 % more blood tubes) with biocontainment sealing or with ertified sealed microplate carriers. BIOShield 1000A max 7.164 x g Runs frequently used tubes above 5.000 x g with the confidence and simplicity of a single, certified biosafety lid. Specifications Sorvall Legend XT Sorvall Legend XTR 4 x 1.000 ml (with TX-rotor) 6.000 rpm (with BIOShield 1000A rotor) 7.164 x g (with BIOShield 1000A rotor) 6 x 250 ml (with F14-6x250LE rotor) 15.200 rpm (with microvolume rotors) 25.314 x g (with 48 x 2 ml rotor) Direct, brushless induction low profile motor Auto-Lock III Imbalance Detection System SMARTSpin 99 (5 with direct access key) Temperature Set Range 10 C to +40 C Pre-Cooling Function Yes, with direct button Refrigeration System CFC free Pulse (Short) Run Yes Acceleration Rates 9 Deceleration Rates 10 Max Timer Range 9 h, 99 min + continuous Sound Level (dba) < 61 dba (TX-750) < 57 dba (TX-750) Certified ClickSeal biocontainment system, language selection 36 x 56.5 x 67 cm 36 x 74.5 x 67 cm 86 kg 116 kg Sorvall Legend, 230 V, 50/60 Hz 75004505 75004520 Fiberlite H3-LV max 2.738 x g Ideal for high-volume microplate processing with a capacity of up to 28 standard plates or 8 deepwell plates per run. Fiberlite F15-6x100 max 24.652 x g Durable design for general purpose pelleting of organelles, density gradients and various protocols requiring angle centrifugation of disposable conical tubes up to 18.516 x g. HIGHConic II max 15.090 x g Process 6 x 94 ml tubes at up to 10.178 x g in certified sealed conditions. Micro-Volumes Rotors Microliter 48 x 2 max 25.314 x g F21-48x2 max 25.055 x g 14 Sorvall Legend XT and XTR are registered products of Thermo Scientific www.thermoscientific.com. 15

Sorvall Legend XF and Legend XFR Benchtop Centrifuge Thermo Scientific Sorvall Legend XF and Legend XFR Benchtop centrifuges featuring market-leading performance, capacity and throughput for high-performance processing. Unmatched capacity with 4 x 750 ml and a wide range of adapters for all research applications, combined with a top speed of 25.314 x g. TX-750 max 4.816 x g Delivers maximum flexibility at 4.700 rpm and features a choice of round or rectangular buckets with multiple adapters as well as microplate carriers. TX-1000 max 4.122 x g Significant productivity improvement compared to competitive models (40 % more 50 ml conical tubes, 100 % more blood tubes) with biocontainment sealing or with ertified sealed microplate carriers. BIOShield 1000A max 7.164 x g Runs frequently used tubes above 5.000 x g with the confidence and simplicity of a single, certified biosafety lid. Specifications Sorvall Legend XF 4 x 1.000 ml (with TX-1000 rotor) 6.000 rpm (with BIOShield 1000A rotor) 7.164 x g (with BIOShield 1000A rotor) 6 x 250 ml (with F14-6x250LE rotor) 15.200 rpm (with microvolume rotors) 25.314 x g (with 48 x 2 ml rotor) Sorvall Legend XFR (refrigerated) Direct, brushless induction low profile motor Auto-Lock III Imbalance Detection System SMARTSpin 99 (5 with direct access key) Temperature Set Range 10 C to +40 C Pre-Cooling Function Yes, with direct button Refrigeration System CFC free Pulse (Short) Run Yes Acceleration Rates 9 Deceleration Rates 10 Max Timer Range 9 h, 99 min + continuous Sound Level (dba) < 64 dba (TX-750) < 58 dba (TX-750) Certified ClickSeal biocontainment system, language selection 79 x 55 x 67 cm 142.5 kg 152.5 kg Sorvall Legend, 230 V, 50/60 Hz 75004532 75004538 Fiberlite H3-LV max 2.738 x g Ideal for high-volume microplate processing with a capacity of up to 28 standard plates or 8 deepwell plates per run. Fiberlite F15-6x100 max 24.652 x g Durable design for general purpose pelleting of organelles, density gradients and various protocols requiring angle centrifugation of disposable conical tubes up to 18.516 x g. HIGHConic II max 15.090 x g Process 6 x 94 ml tubes at up to 10.178 x g in certified sealed conditions. Micro-Volumes Rotors Microliter 48 x 2 max 25.314 x g F21-48x2 max 25.055 x g 16 Sorvall Legend XF and XFR are registered products of Thermo Scientific www.thermoscientific.com. 17

Sorvall LYNX 4000 Superspeed Centrifuge Thermo Scientific Sorvall LYNX BIOFlex HC max 5.500 rpm, 7.068 x g Process over 35 tubestyles from microtubes to 1 L bottles, including conical tubes, microplates, tissue culture flasks and blood bags. Specifications Sorvall LYNX 4000 4 Liters (4 x 1.000 ml), 24 microplates, 96 x 15 ml tubes 5.500 rpm 7.068 x g 4 Liters (4 x 1.000 ml) 10.500 rpm 20.584 x g Touch screen High Torq Brushless Auto-Lock Imbalance Tolerance 5 % of opposite loads (max 25 g) Speed Range Minimum 500 rpm, maximum 24.000 rpm Speed Control Accuracy ± 25 rpm Temperature Set Range -10 C to +4O C Pre-Cooling Function Yes Instrument Boltdown No bolt down required for CE certification Acceleration Rates 9 Deceleration Rates 10 Run Time 99 hrs, hold Sound Level (dba) < 59 dba Multi lingual menu, rotor calculation, user logging Sorvall LYNX 4000, 200 240 V, Single phase (with Polyphase compatibility) Superspeed centrifuge series, featuring powerful technologies with breakthrough simplicity. Exceptional performance meeting evolving application needs, from academic research to production facilities, with up to 68.905 x g, and up to 4 Liters capacity. 930 x 805 x 700 mm 283 kg 75006580 Fiberlite Rotors BIOFlex HS max 7.000 rpm, 10.025 x g Versatility of adapter options supporting more than 30 tube types from microtubes to conical tubes to 400 ml bottles. F10-4x1000 LEX max 10.500 rpm. 20.584 x g Process 4 Liters per run in lighter weight Fiberlite LEX design for large volume or bioprocessing or the flexibility of adapters for labware from 1.5 to 500 ml. F12-6x500 LEX max 12.000 rpm, 24.471 x g Run popular 500 ml bottles to over 24.000 x g, with adapters available for smaller bottles. F14-6x250 LEX max 14.000 rpm, 30.240 x g Ideal for tissue homogenates, or smaller volume yeast or bacterial culture separations in up to 250 ml bottles. F21-8x50 max 18.000 rpm, 38.759 x g 50 ml 34 angle rotor for subcellular separations with the same specifications as the most popular Sorvall SS34 rotor. F14-14x50cy max 13.000 rpm, 29.097 x g Dedicated solution for 50 ml conical tubes, with adapters for 15 ml or other tubes, for pelleting cells, tissue homogenates, or subcellular separations. 18 Sorvall LYNX 4000 is a registered product of Thermo Scientific www.thermoscientific.com. 19

Sorvall LYNX 6000 Superspeed Centrifuge Thermo Scientific Sorvall LYNX BIOFlex HC max 5.500 rpm, 7.068 x g Process over 35 tubestyles from microtubes to 1 L bottles, including conical tubes, microplates, tissue culture flasks and blood bags. Specifications Sorvall LYNX 6000 Superspeed centrifuge series, featuring powerful technologies with breakthrough simplicity. Exceptional performance meeting evolving application needs, from academic research to production facilities, with up to 100.605 x g, and up to 6 Liters capacity. 4 Liters (4 x 1.000 ml), 24 microplates, 96 x 15 ml tubes 5.500 rpm 7.068 x g 6 Liters (6 x 1.000 ml) 9.000 rpm 14.586 x g Touch screen High Torq Brushless Auto-Lock Imbalance Tolerance 5 % of opposite loads (max 25 g) Speed Range Minimum 500 rpm, maximum 29.000 rpm Speed Control Accuracy ± 25 rpm Temperature Set Range -20 C to +4O C Pre-Cooling Function Yes Instrument Boltdown No bolt down required for CE certification Acceleration Rates 9 Deceleration Rates 10 Run Time 99 hrs, hold Sound Level (dba) < 59 dba Multi lingual menu, rotor calculation, user logging Sorvall LYNX 6000 Single phase Sorvall LYNX 6000 3 phase 930 x 805 x 700 mm 293 kg 200 240 V, 50/60 Hz, 30 A 380 400 V, 50/60 Hz, 16 A Fiberlite Rotors Titanium Rotor BIOFlex HS max 7.000 rpm, 10.025 x g Versatility of adapter options supporting more than 30 tube types from microtubes to conical tubes to 400 ml bottles. F9-6x1000 LEX max. 9.000 rpm, 17.568 x g Process 6 Liters per run in lighter weight Fiberlite LEX design for large volume or bioprocessing or the flexibility of adapters for labware from 1.5 to 500 ml. F12-6x500 LEX max. 12.000 rpm, 24.471 x g Run popular 500 ml bottles to over 24.400 x g, with adapters available for smaller bottles F14-6x250 LEX max 14.000 rpm, 30.240 x g Ideal for tissue homogenates, or smaller volume yeast or bacterial culture separations in up to 250 ml bottles. F21-8x50 max 20.000 rpm, 47.850 x g 50 ml 34 angle rotor for subcellular separations with the same specifications as the most popular Sorvall SS34 rotor. F14-14x50cy max 14.000 rpm, 33.746 x g Dedicated solution for 50 ml conical tubes, with adapters for 15 ml or other tubes, for pelleting cells, tissue homogenates, or subcellular separations. T29-8x50 max 29.000 rpm, 100.605 x g Realise new level of high g-force (up to 100.605 x g) in a superspeed using the standard 50 ml round bottom tubes. 20 Sorvall LYNX 6000 is a registered product of Thermo Scientific www.thermoscientific.com. 21

Sorvall MTX 150 Benchtop Micro-Ultracentrifuge Thermo Scientific Sorvall MTX 150 A micro-ultracentrifuge which delivers excellent performance and versatility for rapid small-volume processing. S5-ST max 275.458 x g Recommended for DNA/RNA isolation, density gradients and small particle pelleting. Capacity: 4 x 5 ml. S50-ST max 252.721 x g Designed to spin up to 28 ml in a single run. Top loading buckets reduce mishandling resulting in greater safety. Capacity: 4 x 7 ml. With RCF up to 1.048.684 x g the MTX 150 features advanced functionality in a compact footprint. S140-AT max 1.048.684 x g Fixed angle rotor ideal for rapid separation or serum lipoproteins, DNA, RNA and subcellar fractionation. Capacity: 10 x 2 ml. Specifications Sorvall MTX 150 S150-AT max 899.744 x g Ideal for high speed applications at 150.000 rpm combined with a total capacity of 16 ml. Capacity: 8 x 2 ml. 22 4 x 7 ml (with S50-ST) 55.500 rpm (with S55-S) 275.458 x g (with S52-ST) 6 x 30 ml (with S50-A) 150.000 rpm (with S150-AT) 1.048.684 x g (with S140-AT) Self Locking Rotor System Imbalance Detection System Imbalance tolerant drive and eye-balancing 20, each with up to 9 steps Temperature Set Range 0 C to +40 C Refrigeration System Solid-state thermoelectric cooling Acceleration Profiles 9 Deceleration Profiles 9 Speed Control Accuracy (rpm) ± 50 Sound Level (dba) < 45 dba Certified ClickSeal biocontainment system, language selection Sorvall MTX 150, 220 V, 50/60 Hz 46962 40.8 x 59 x 58.2 cm 97 kg Sorvall MTX 150 is a registered product of Thermo Scientific www.thermoscientific.com. S110-AT max 690.652 x g 17 % faster separation time compared to the previous generation of micro-ultracentrifuges. Capacity: 8 x 5 ml. S120-AT2 max 649.826 x g Effectively centrifugalize samples during pelleting and gradient seperations with this rotor. Capacity: 10 x 2 ml. S50-A max 209.438 x g New T-shape handle for easy opening and closing of the rotor combined with a large 40 ml capacity. Capacity: 8 x 5 ml. 23

Sorvall MX 120 Plus Floorstanding Micro-Ultracentrifuge Thermo Scientific Sorvall MX 120 Plus A micro-ultracentrifuge which delivers excellent performance and versatility for rapid small-volume processing. S52-ST max 275.458 x g Recommended for DNA/RNA isolation, density gradients and small particle pelleting. Capacity: 4 x 5 ml. S50-ST max 252.721 x g Designed to spin up to 28 ml in a single run. Top loading buckets reduce mishandling resulting in greater safety. Capacity: 4 x 7 ml. With RCF up to 770.460 x g the MX 120 plus features advanced functionality in a compact footprint. S140-AT max 1.048.684 x g Fixed angle rotor ideal for rapid separation or serum lipoproteins, DNA, RNA and subcellar fractionation. Capacity: 10 x 2 ml. Specifications Sorvall MX 120 Plus S150-AT max 899.744 x g Ideal for high speed applications at 150.000 rpm combined with a total capacity of 16 ml. Capacity: 8 x 2 ml. 24 4 x 7 ml (with S50-ST) 55.500 rpm (with S55-S) 275.458 x g (with S52-ST) 6 x 30 ml (with S50-A) 120.000 rpm (with S150-AT) 770.460 x g (with S140-AT) Self Locking Rotor System Imbalance Detection System Imbalance tolerant drive and eye-balancing 10, each with up to 9 steps Temperature Set Range 0 C to +40 C Refrigeration System Solid-state thermoelectric cooling Acceleration Profiles 9 Deceleration Profiles 9 Speed Control Accuracy (rpm) ± 50 Sound Level (dba) < 45 dba Certified ClickSeal biocontainment system, language selection Sorvall MX 120 Plus, 220 V, 50/60 Hz 46957 80.5 x 44 x 49 cm 110 kg Sorvall MX 120 Plus is a registered product of Thermo Scientific www.thermoscientific.com. S110-AT max 690.652 x g 17 % faster separation time compared to the previous generation of micro-ultracentrifuges. Capacity: 8 x 5.0 ml. S120-AT2 max 649.826 x g Effectively centrifugalize samples during pelleting and gradient seperations with this rotor. Capacity: 10 x 2.0 ml. S50-A max 209.438 x g New T-shape handle for easy opening and closing of the rotor combined with a large 40 ml capacity. Capacity: 8 x 5 ml. 25

Sorvall MX 150 Plus Floorstanding Micro-Ultracentrifuge Thermo Scientific Sorvall MX 150 Plus A micro-ultracentrifuge which delivers excellent performance and versatility for rapid small-volume processing. S52-ST max 275.458 x g Recommended for DNA/RNA isolation, density gradients and small particle pelleting. Capacity: 4 x 5 ml. S50-ST max 252.721 x g Designed to spin up to 28 ml in a single run. Top loading buckets reduce mishandling resulting in greater safety. Capacity: 4 x 7 ml. With RCF up to 1.048.684 x g the MX 150 Plus features advanced functionality in a compact footprint. S140-AT max 1.048.684 x g Fixed angle rotor ideal for rapid separation or serum lipoproteins, DNA, RNA and subcellar fractionation. Capacity: 10 x 2 ml. Specifications Sorvall MX 150 Plus S150-AT max 899.744 x g Ideal for high speed applications at 150.000 rpm combined with a total capacity of 16 ml. Capacity: 8 x 2 ml. 26 4 x 7 ml (with S50-ST) 55.500 rpm (with S55-S) 275.458 x g (with S52-ST) 6 x 30 ml (with S50-A) 150.000 rpm (with S150-AT) 1.048.684 x g (with S140-AT) Self Locking Rotor System Imbalance Detection System Imbalance tolerant drive and eye-balancing 10, each with up to 9 steps Temperature Set Range 0 C to +40 C Refrigeration System Solid-state thermoelectric cooling Acceleration Profiles 9 Deceleration Profiles 9 Speed Control Accuracy (rpm) ± 50 Sound Level (dba) < 48 dba Certified ClickSeal biocontainment system, language selection 80.5 x 44 x 49 cm 110 kg Sorvall MX 150 Plus, 220 V, 50/60 Hz 50135643 Sorvall MX 150 Plus is a registered product of Thermo Scientific www.thermoscientific.com. S110-AT max 690.652 x g 17 % faster separation time compared to the previous generation of micro-ultracentrifuges. Capacity: 8 x 5 ml. S120-AT2 max 649.826 x g Effectively centrifugalize samples during pelleting and gradient seperations with this rotor. Capacity: 10 x 2 ml. S50-A max 209.438 x g New T-shape handle for easy opening and closing of the rotor combined with a large 40 ml capacity. Capacity: 8 x 5 ml. 27

Sorvall WX 100+, WX 90+, WX 80+ Floorstanding Ultracentrifuges AH-629 max 151.240 x g Facilitate large volume particle isolations using the 36 ml or 17 ml AH-629 rotor. Capacity: 6 x 36 ml or 6 x 17 ml. Thermo Scientific Sorvall WX+ Series Ultracentrifuges designed to change your expectation of ultacentrifuges. Combining outstanding speed with exceptional safety and ergonomics. The Sorvall WX+ Ultracentrifuge-Series provides a new level of convenience and ease-of-use. SureSpin 630/36 max 166.880 x g Effective sample processing with this swing-out rotor. Capacity: 6 x 36 ml. F50L-8X39 max 266.000 x g Reduces the required number of runs for high-volume seperations in a carbon fiber rotor that features two additional tube cavities. Capacity: 8 x 39 ml. Specifications Sorvall WX+ 100 Sorvall WX+ 90 Sorvall WX+ 80 A-621 max 66.990 x g Ideal for high speed large volume applications at 21.000 rpm combined with a total capacity of 1.5 L. Capacity: 6 x 250 ml. 28 6 x 36 ml (with AH-629) 60.000 rpm (with TH-660) 488.580 x g (with TH-660) 6 x 250 ml (with S50-A) 100.000 rpm 90.000 rpm 80.000 rpm 802.000 x g 692.142 x g 546.883 x g Imbalance Detection System Imbalance tolerant drive and eye-balancing 1.000 programs; Step-Run Temperature Set Range +2 C to +40 C Refrigeration System Solid-state thermoelectric refrigeration (CFC free) Acceleration Profiles 10 Deceleration Profiles 11 Vacuum System Oil-rotary vacuum pump (vacuum of 0.13 Pa) Sound Level (dba) < 51 dba Automatic RCF, Rotor Life Management, CE and ccsaus certified 88 x 79 x 69 cm 390 kg Sorvall WX+, 208 240 V, 50/60 Hz 75000100 75000090 75000080 Sorvall WX is a registered product of Thermo Scientific www.thermoscientific.com. Vertical Rotors Continous Flow Rotor T-8100 max 802.010 x g Created for a variety of applications with an eight-place capacity. Capacity: 8 x 6.5 ml. StepSaver 65V13 max 400.670 x g Easy and quick load and unload of the rotor to minimise sample loss. Capacity: 8 x 13.5 ml. TCF-32 max 102.000 x g Created to perform multi-liter processing applications that require high RCF s such as viral seperations, particle isolations and vaccine production. Capacity: 430 ml. 29

Sorvall RC3BP Plus Low-Speed Centrifuge Thermo Scientific Sorvall RC3BP Plus Low speed centrifuge for easy and user-friendly low-speed processing with advanced functionality that maximises reproducibility and throughput. Exceptional Performance in Batch Processing with a wide range of rotors and a diverse array of adapters to create the highest versatility combined with more than 7.000 x g and 6 Liters capacity. H-6000A max 5.000 rpm; 7.277 x g Multi-tasking performance for blood banking and general purpose seperations. n 6 x 1 L capacity for large batch bioprocessing n Up to 6 single, double, triple or quad blood bags n Wide range of adapters available n Possibility to centrifuge 6 x 3 standard or 6 x 1 deepwel microplates HBB-6 Flexibility for blood banking. n 6 x 550 ml capacity for up to 6 whole blood bags max 5.000 rpm, 7.129 x g n Designed specifically for blood banking market n Wide range of adapters available Specifications Sorvall RC3BP Plus 6 x 1.000 ml 5.000 rpm 7.277 x g High-performance Induction Speed Range Minimum 300 rpm, maximum 5.000 rpm Speed Control Accuracy ± 20 rpm Temperature Set Range -10 C to +40 C Imbalace Detector 50 gram tolerance Acceleration Rates 11 Deceleration Rates 11 Programmability 15 programs Run Rime 1 min. 99 hours, continuous operation Sorvall RC3BP Plus, 208 220 V, Single phase 75007530 Automatic Lid Lock, Steel armoured ring, security key, Step-Mode Runs, ACE 1.178 x 800 x 905 mm 445 kg n Adapters for 12 platelet-rich plasma and buffy coat bags HLR-6 High capacity for in-line leukofiltration. n Separate filter holder to preserve blood bag integrity max 5.000 rpm, 7.205 x g n 6 x 550 ml capacity for up to 6 triple, quad or quint blood bags with in-line filters n Optimized for soft-spin conditions for production of leukp-reduced packed red cells and platelet concentrates 30 Sorvall RC3BP Plus is a registered product of Thermo Scientific www.thermoscientific.com. 31

Sorvall RC 12BP Plus Large Capacity Centrifuge Powering the most demanding processing applications Thermo Scientific Sorvall RC 12BP Plus Large capacity centrifuge for high-throughput, large volume blood-banking and bioprocessing applications. With the highest throughput in a single step and advanced capabilities it is the ideal solution for large-batch bioprocessing applications in biotechnology and pharmaceutical laboratories. Process Bacterial and Yeast Cultures and Clarify Broths A 6 x 2.000 ml bottle capacity will allow you to process a 12-Liter bioreactor harvest in a single run. The Accumulated Centrifugal Effect (ACE) function and slow start/stop modes maximise yields and reproducibility when pelleting. Specifications Sorvall RC 12BP Plus 6 x 2.000 ml (with H-12000 Bioprocessing rotor) 12 x 500 ml (with H-12000 Blood processing rotor) 4.700 rpm 7.340 x g High performance induction Speed Range Minimum 150 rpm, maximum 4.700 rpm Speed Control Accuracy ± 20 rpm Temperature Set Range -10 C to +40 C Imbalace Detector 50 gram tolerance Acceleration Rates 11 Deceleration Rates 11 Programmability 15 programs Run Time 1 min. 99 min. 59 sec., continuous operation Sorvall RC 12BP Plus, 220 230 V, Single phase 75007032 Automatic lid lock, imbalance detection, armored guard ring, security key switch, Centri-Log traceability software, Step-mode runs, slow start/stop 1.178 x 800 x 905 mm 470 kg Protect Valuable Samples With the Sorvall RC 12BP Plus centrifuge, you can control acceleration and deceler ation rates for delicate low-speed pelleting. Harvest Mammalian Cell and Tissue Cultures Adapters for the H-12000 rotor simplify cell and tissue culture harvests, letting you spin sample vessels ranging from 2 L bottles down to 50/15 ml conical tubes. 32 Sorvall RC 12BP is a registered product of Thermo Scientific www.thermoscientific.com. 33

Sorvall RC BIOS Centrifuge Rotor Care and Safety program Thermo Scientific Sorvall RC BIOS High Performance batch bioprocessing system for industryleading results. Large capacity centrifuge for high-throughput, large volume blood-banking and bioprocessing applications. With the highest throughput in a single step and advanced capabilities it is the ideal solution for large-batch bioprocessing applications in biotechnology and pharmaceutical laboratories. This service is available for all type of customers that work with centrifuges independent of the brand you are using Are you aware of the dangerous situations and possible problems that can occur during use, from experience all in all many long years, of a centrifuge on your laboratory? Be pro-active and plan on regular base a rotor maintenance and safety clinic to be sure that your investments are secured. Please contact the Sysmex Academy for an offer based on your needs taking into account the use and maintenance need of your rotor(s). Specifications Sorvall RC BIOS 6 Sorvall RC BIOS 10 F8 6 x 1.000 rotor F5 10 x 1.000 rotor 6 x 1.000 ml Nalgene Bottles 10 x 1.000 ml Nalgene Bottles 8.500 rpm 5.500 rpm 15.860 x g 9.333 x g High performance induction Temperature Set Range -10 C to +40 C Imbalace Detector 50 gram tolerance Acceleration Rates 11 Deceleration Rates 11 Programmability 15 programs Run Time 1 min. 99 min. 59 sec., continuous operation Automatic lid lock, imbalance detection, steel armored guard ring, security key switch, Traceability software, Step-mode runs, slow start/stop 1.178 x 800 x 905 mm 470 kg Sorvall RC BIOS package 400 V 3 phase 75007047 75007054 Sorvall RC BIOS package 220 230 V, Single phase 75007046 Including: n Fiberlite F8-6x1000 rotor n 6 x 1 L Superspeed centrifuge bottle 75007053 Including: n Fiberlite F5-10x1000 rotor n 10 x 1 L Superspeed centrifuge bottle We offer you our Rotor Care and Safety program This Rotor Care and Safety program will be held on your location by our product specialist. It will be a two hour program within which you as user and technical superintendent of your centrifuge(s) will get the information of correct daily use, maintenance and safety aspects. Also you are able to ask your questions regarding which rotor to be used on what application. It is advised to have this program executed on a regular base. Costs of this training will be implemented in your maintenance contract when implemented on a regular base. Otherwise we recommend to have this training at least every three year or when your staffing of users this requires. The costs of this training and safety program are 225,- * (on location), independent the number of participants, brand and types of centrifuge(s) or rotor(s). During the life cycle of your instrument with this program you will guarantee a proper knowledge for optimal use in your working environment. 34 Sorvall RC BIOS is a registered product of Thermo Scientific www.thermoscientific.com. * Including Rotor Care and Safety Certificate 35

Sysmex Academy 2015 Materials & Life Sciences Are your interested in our education program? Please ask for our trainingsguide Design and specifications may be subject to change due to further product development. Changes are confirmed by their appearance on a newer document and verification according to its date of issue. Copyright 2015 Sysmex Europe GmbH Centrifuge Distributor The Netherlands: Sysmex Nederland B.V. Ecustraat 11, 4879 NP Etten-Leur, The Netherlands Phone +31 76 5086000 Fax +31 76 5086086 info@sysmex.nl www.sysmex.nl Distributor Belgium: Sysmex Belgium N.V. Park Rozendal, Building A, Terhulpsesteenweg 6a, 1560 Hoeilaart, Belgium Phone +32 2 7697474 Fax +32 2 7697499 info@sysmex.be www.sysmex.be Manufacturer: Thermo Scientific Takkebijsters 1, 4817 BL Breda, The Netherlands You will find your local Sysmex representative s address under www.sysmex-europe.com/contacts CENTRIFUGEGUIDE.EN.N.03/15