Appendix A: 1 year survival:
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1 Appendix A: 1 year survival: One year survival for the top 20 most common cancers in males and females by deprivation (SIMD), Scotland Males Females Period of diagnosis (M) (F) Cancer Deprivation Survival (%) 95% CI Survival (%) 95% CI Lung 1 (most deprived) (least deprived) Breast (female) 1 (most deprived) (least deprived) Colorectal 1 (most deprived) (least deprived) Prostate 1 (most deprived) (least deprived) Head and Neck 1 (most deprived) (least deprived) Malignant Melonoma of the Skin 1 (most deprived) (least deprived) Non-Hodgkin's Lymphoma 1 (most deprived) (least deprived) Kidney 1 (most deprived) (least deprived) Oesophagus 1 (most deprived) (least deprived) Bladder 1 (most deprived) (least deprived)
2 One year survival for the top 20 most common cancers in males and females by deprivation (SIMD), Scotland Males Females Period of diagnosis (M) (F) Cancer Deprivation Survival (%) 95% CI Survival (%) 95% CI Pancreas 1 (most deprived) (least deprived) Corpus uteri 1 (most deprived) (least deprived) Stomach 1 (most deprived) (least deprived) Liver 1 (most deprived) (least deprived) Ovary 1 (most deprived) (least deprived) Leukaemia 1 (most deprived) (least deprived) Brain and CNS 1 (most deprived) (least deprived) Cervix 1 (most deprived) (least deprived) Thyroid* 1 (most deprived) (least deprived) Mesothelioma* 1 (most deprived) (least deprived) * Thyroid cancer in Men and Women and Mesothelioma in Women are not age standardised due to small numbers 2
3 Appendix B: Males Females year Survival 5-year Survival 1-year Survival 1-year Survival 5-year Survival 1-year Survival Cancer Deprivation Total Deaths Total Deaths Total Deaths Total Deaths Total Deaths Total Deaths Lung 1 (most deprived) (Least deprived) Breast (female) 1 (most deprived) (Least deprived) Colorectal 1 (most deprived) (Least deprived) Prostate 1 (most deprived) (Least deprived) Head and Neck 1 (most deprived) (Least deprived) Malignant Melon1 (most deprived) (Least deprived) Non-Hodgkin's L1 (most deprived) (Least deprived) Kidney 1 (most deprived) (Least deprived) Oesophagus 1 (most deprived) (Least deprived) Bladder 1 (most deprived) (Least deprived) Pancreas 1 (most deprived) (Least deprived) Corpus uteri 1 (most deprived) (Least deprived)
4 Males Females year Survival 5-year Survival 1-year Survival 1-year Survival 5-year Survival 1-year Survival Cancer Deprivation Total Deaths Total Deaths Total Deaths Total Deaths Total Deaths Total Deaths Stomach 1 (most deprived) (Least deprived) Liver 1 (most deprived) (Least deprived) Ovary 1 (most deprived) (Least deprived) Leukaemia 1 (most deprived) (Least deprived) Brain and CNS 1 (most deprived) (Least deprived) Cervix 1 (most deprived) (Least deprived) Thyroid 1 (most deprived) (Least deprived) Mesothelioma 1 (most deprived) (Least deprived)
5 Appendix C: Further information on factors incorporated into model Personal Characteristics Cancer Code Colorectal Female Breast C18-C20 C50 Tumour-related Characteristics Head and neck C00-C14, C30-C32 Liver Malignant melanom a of the skin Oesophagus Prostate Trachea, bronchus and lung C22 C43 C15 C61 C33 - C34 Cases included Gender Male* Male* Male* Male* Male* Male* Female Female Female Female Female Female Age (average) Charlson index of co-morbidity X X X X X X X X Inpatient bed days X X X X X X X X Colorectal Female Breast Head and neck Liver Malignant melanoma of the skin Oesophagus Prostate Trachea, bronchus and lung Cancer Grade of differentiation 1* I* 1* 1-4* 1* 1* 2 II III/ IV Stage Dukes' stage TNM Stage Clark level Gleason score Stage A* 1* 2* 1-4* 1* B C D Pre-2005 Breslow Thickness (average) Median (1mm) Clinical Extent 1* Metastases within 4 months ER Status Small Cell Positive* Negative Tumour morphology Polyp-related* Very good* Liver Cell Carcinoma* Yes Yes Yes Yes Yes No evidence* No evidence* No evidence* No evidence* No evidence* Superficial spreading melanoma* Nodular melanoma Adenocarcinoma* Poor prognosis Good Intrahepatic Bile duct Squamous cell carcinoma Intermediate Sarcomas Lentigo malignant melanoma Poor Others Acral lentiginous melanoma Very poor prognosis Site/Subsite Lip* Arm* Upper Oral cavity Head and neck Middle Salivary glands Trunk Lower* Pharynx Leg Nasal cavity & middle ear & sinuses Larynx Small cell* 5
6 Treatment-related Characteristics Cancer Colorectal Female Breast Screen-detected Yes* Yes* Clinical trial No No Yes* No Where * represents reference category Head and neck Liver Malignant melanom a of the skin Oesophagus Prostate Surgery Yes* Yes* Yes* Yes* Yes* Yes* Yes* No No No No No No No Radiotherapy Yes* Yes* Yes* Yes* Yes* Yes* No No No No No No Chemotherapy Yes* Yes* Yes* Yes* Yes* Yes* No No No No No No Hormonal Therapy Yes* Yes No No* Trachea, bronchus and lung Breast Cancer Divide tumour morphology into categories reflecting prognosis, based on US SEER data (Berg JW, Hutter RVP. Breast Cancer. Cancer 1995; 75(Suppl 1): ). 1. Very good prognosis (5-year RS 90%) Medullary carcinoma with lymphoid stroma, Mucinous (colloid) carcinoma, Papillary carcinoma, Tubular carcinoma, Adenoid cystic carcinoma, Cribriform carcinoma 2. Good prognosis (5-year RS 80-89%) Lobular carcinoma, Medullary carcinoma NOS, Duct and lobular carcinoma, Comedocarcinoma, Scirrhous carcinoma 3. Intermediate prognosis (5-year RS 70-79%) Ductal carcinoma NOS, Paget s disease 4. Poor prognosis (5-year RS 60-69%) Adenocarcinoma NOS, Carcinoma NOS 5. Very poor prognosis Inflammatory carcinoma 6. Other or not known See table below for ICD-O M-codes 6
7 Morphology categories Morphology codes** 1. Very good prognosis 8050, , 8211, 8260, , 8503, 8512, 2. Good prognosis 8141, 8501, , , Intermediate prognosis 8500, Poor prognosis , , Very poor prognosis Other or not known All other M-codes Colorectal Cancer Divide tumour morphology into categories: polyp-related, poor and other Polyp-related = 8210/3, 8221/3, 8261/3, 8263/3 Poor = 8020/3, 8480/3, 8481/3, 8490/3 Other/ = all other morphology codes ending in /3 Head and Neck Cancer Divide tumour site into categories: Lip (C00) Oral cavity (C01-C06) Salivary glands (C07-C08) Pharynx (C09-C14) Nasal cavity, middle ear, sinuses (C30-C31) Larynx (C32) Liver Cancer Divide tumour histology into categories: liver cell carcinoma, intrahepatic bile duct carcinoma, sarcomas and others combined Liver cell carcinoma = C22.0 Intrahepatic bile duct carcinoma = C22.1 Sarcomas = C22.3-C22.4 Others combined = C22.2, C22.7, C22.9 7
8 Lung Cancer Divide tumour morphology into categories: small cell vs other Small cell = M-8041/3 M-8045/3 Other = all other morphology codes ending in /3 Malignant Melanoma of Skin Divide morphology into categories: Superficial spreading melanoma = 8743/3 Nodular melanoma = 8721/3 Lentigo malignant melanoma = 8742/3 Acral lentiginous melanoma = 8744/3 All other melanomas combined ending in /3 Oesophageal Cancer Divide tumour morphology into categories: Squamous cell carcinoma = 8050/3-8078/3, 8083/3-8084/3 Adenocarcinoma = 8140/3-8141/3, 8143/3-8145/3, 8190/3-8231/3, 8260/3-8263/3, 8310/3, 8401/3, 8480/3-8490/3, 8550/3-8551/3, 8570/3-8574/3, 8576/3 All other melanomas combined ending in /3 Divide tumour subsite into categories: Upper (C15.0, C15.3) Middle (C15.1, C15.4) Lower (C15.2, C15.5) Other or unspecified (C15.8-C15.9) 8
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