Annex. Global registry and database on craniofacial anomalies. Cleft lip with or without cleft palate (maps) Cleft palate without cleft lip (maps)
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1 Annex Table 1 Table 2 Table 3 Figure 1 Figure 2 Figure 3 Cleft lip with or without cleft palate Cleft palate without cleft lip ICBDMS synopsis of 28 monitoring systems, and prevalence rates and secular trends for oral clefts Cleft lip with or without cleft palate (bar chart) Cleft palate without cleft lip (bar chart) Cleft lip with or without cleft palate (maps) a) The Americas b) Asia, Australia and Oceania, Africa, Middle East c) Europe Figure 4 Cleft palate without cleft lip (maps) a) The Americas b) Asia, Australia and Oceania, Africa, Middle East c) Europe Figure 5 Rates for cleft palate and cleft lip with or without cleft palate, Figure 6 Monthly report form for examined births 85
2 Report of a WHO Registry Meeting on Craniofacial Anomalies Table 1: Cleft lip with or without cleft palate Programme Years Cases Births Rate per 95% CI* Trend from to lower upper Bolivia Japan JAOG Paraguay Germany Saxony-Anhalt China CBDMN Northern Netherlands Norway Denmark Odense Mexico RYVEMCE Argentina China Beijing Brazil Canada Alberta Belgium Antwerp France Strasbourg Scotland Glasgow Ecuador Finland Chile Czech Republic Colombia United States Atlanta Ireland Dublin Australia Belgium Hainaut Austria Styria Malta England Mersey Venezuela Southern Portugal Switzerland Zurich Spain Asturias France Central East continued/... 86
3 Table 1: Cleft lip with or without cleft palate (continued) Programme Years Cases Births Rate per 95% CI* Trend from to lower upper Hungary Uruguay France Paris UK North Thames West Italy ISMAC Bulgaria Sofia Italy BDRCAM Croatia Zagreb Italy IMER Cuba England and Wales Italy North East Spain Basque Country United Arab Emirates Italy Tuscany Spain ECEMC Spain El Valles Spain Barcelona New Zealand Russia Tomsk Canada South Africa SABDSS Israel IBDMS * Bold characters do not represent the confidence interval (CI) but the range (for heterogenous prevalence only). 87
4 Report of a WHO Registry Meeting on Craniofacial Anomalies Table 2: Cleft palate without cleft lip* Programme Period Cases Births Rate per 95% CI Trend from to lower upper Canada British Columbia Finland Malta Canada Alberta Scotland Glasgow Ireland Dublin France Strasbourg Canada Paraguay Belgium Hainaut Germany Saxony-Anhalt Austria Styria Australia New Zealand Czech Republic Croatia Zagreb Denmark Odense France Central East Spain Asturias Switzerland Zurich Norway England Mersey Southern Portugal Spain Basque Country Israel IBDMS Northern Netherlands Belgium Antwerp Italy ISMAC Chile Italy IMER Japan JAOG France Paris USA Atlanta continued/... 88
5 Table 2: Cleft palate without cleft lip (continued) Programme Period Cases Births Rate per 95% CI* Trend from to lower upper Brazil Italy BDRCAM Ecuador England North Thames West Spain ECEMC Italy North East Argentina Uruguay Italy Tuscany United Arab Emirates Mexico RYVEMCE China Beijing Spain Barcelona England and Wales Venezuela Russia Tomsk Hungary Spain El Valles China CBDMN Bolivia Bulgaria Sofia South Africa SABDSS Colombia Cuba * Bold characters do not represent the confidence interval but the range (for heterogenous prevalence only). 89
6 Report of a WHO Registry Meeting on Craniofacial Anomalies Table 3: Synopsis of 28 monitoring systems: prevalence rates and secular trends for oral clefts Monitoring Coverage Maximum Criteria Annual CL/P CL/P CP/ CP programme age at defining births rate/ trend rate/ trend diagnosis stillbirths (1998) Australia Population-based Hospital 20 weeks # 7.34 discharge or 400 g Canada Alberta Population-based 1 year 20 weeks # 9.19 Provincial or 500 g Canada Population-based 1 year 20 weeks # 5.89 China Beijing Population-based 6 weeks 20 weeks NA 1.90 NA Four provinces China CBDMN Hospital-based 7 days 28 weeks NA 2.53 NA Czech Republic Population-based Up to 15 years 500 grams # 6.68 # Bohemia & Moravia England Population-based 1995 onwards 24 weeks and Wales no limit Finland Population-based 1 year 22 weeks or 500 g France Population-based 1 year 22 weeks # 3.93 # Central-East France Paris Population-based Hospital 22 weeks # 3.93 # discharge France Population-based 1 year 26 weeks # 3.62 # Strasbourg Hungary Population-based 1 year 28 weeks Ireland Dublin Population-based 10 years 24 weeks # 4.95 # or 500 g Israel IBDMS Hospital-based Hospital 28 weeks # 3.23 # discharge Italy BDRCam Hospital-based 7 days 180 days # 4.43 # Italy IMER Population-based 7 days 180 days # 0.42 # Italy ISMAC Hospital-based 1 year 180 days NA NA NA NA Italy North East Population-based 7 days 180 days Italy Tuscany Population-based 7 days 180 days # continued/... 90
7 Table 3: Synopsis of 28 monitoring systems: prevalence rates and secular trends for oral clefts (continued) Monitoring Coverage Maximum Criteria Annual CL/P CL/P CP/ CP programme age at defining births rate/ trendrate/ trend diagnosis stillbirths (1998) Japan JAOG Hospital-based 7 days 22 weeks h 4.12 i Malta Hospital-based 1 year 24 weeks # # Mexico RYVEMCE Hospital-based 72 hours 20 weeks # 2.40 # or 500 g New Zealand Population-based 1 year 20 weeks # or 400 g Northern Population-based No limit 24 weeks # 7.44 # Netherlands Norway Population-based Hospital 16 weeks # discharge South Africa Hospital-based Hospital not recorded # 3.05 # SABDSS discharge South America Hospital-based 3 days 500 g ECLAMC Multinational Spain ECEMC Hospital-based 3 days 24 weeks # or 500 g Sweden Population-based 28 days 22 weeks NA 6.33 NA United Arab Hospital-based 7 days 23 weeks NA 7.72 NA Emirates USA Atlanta Population-based 1 year 20 weeks # or 500 g USA California Population-based 1 year 20 weeks NA NA NA NA # Secular trend, stable Secular trend, decreasing Secular trend, increasing NA Data not available. Source: WHO,
8 Report of a WHO Registry Meeting on Craniofacial Anomalies Figure 1: Cleft lip with or without cleft palate (Birth prevalences per with CI/range)* * Where the bars are not displayed, the line represents the range. 92
9 Figure 2: Cleft palate without cleft lip (Birth prevalences per with CI/range)* * Where the bars are not displayed, the line represents the range. 93
10 Report of a WHO Registry Meeting on Craniofacial Anomalies Figure 3a: Cleft lip with or without cleft palate The Americas 94
11 Figure 3b: Cleft lip with or without cleft palate Asia, Middle East, Australia & Oceania, Africa 95
12 Report of a WHO Registry Meeting on Craniofacial Anomalies Figure 3c: Cleft lip with or without cleft palate Europe 96
13 Figure 4a: Cleft palate without cleft lip The Americas 97
14 Report of a WHO Registry Meeting on Craniofacial Anomalies Figure 4b: Cleft palate without cleft lip Asia, Middle East, Australia & Oceania, Africa 98
15 Figure 4c: Cleft palate without cleft lip Europe 99
16 Report of a WHO Registry Meeting on Craniofacial Anomalies Figure 5: Rates for cleft palate and cleft lip with or without cleft palate, Source: Bianchi F (2001) EUROCATOC: A collaborative study on oral clefts in EUROCAT registries during the period Preliminary analysis 100
17 Figure 6: Monthly report form for examined births Registry: Month: Year: Live births Stillbirths Live births Stillbirths Live births Stillbirths Twinning Singletons Not specified Total Cases reported Autopsies or more Not specified Total < Not specified Total W e i g h t S e x G r a v i d i t y B i r t h p l a c e M o t h e r s a g e Male Female Intersex Not specified Total < 500 ///////// Not specified Total Source: ICBDMS,
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